Human PI3K-AKT Signaling Pathway

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Oligo GEArray® Human PI3K-AKT Signaling Pathway Microarray

See this Pathway in PCR Array Format!
HybTube Format Cat. No.: OHS-058
HybPlate Format Cat. No.: EHS-058

Description

The Oligo GEArray® Human PI3K-AKT Signaling Pathway Microarray is designed for profiling the expression of 113 genes involved in PI3K-AKT signaling. This array contains members of the AKT (Protein Kinase B) and PI3K families and their regulators. Genes involved in several biological processes are represented including inactivation of Gsk3 and the accumulation of b-catenin, regulation of actin organization and cell migration, and BAD phosphorylation. Genes involved in the IGF-1, mTOR, and anti-apoptotic pathways are also contained in this array. Regulators of eIF4e and p70 S6 kinase activity are included as well. Through a simple side-by-side hybridization experiment you can determine differential gene expression between your samples.

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Useful Links

Pricing and Ordering	Gene Table	GEArray Service
User Manual	White Paper	GEArray ThermoShaker

Related Products for the Genes on This Array

shRNA Plasmids

qPCR Gene Assays

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Functional Gene Grouping

AKT and PI3K Family Members and Their Regulators: AKT1, AKT2, AKT3, APPL, BTK, CTMP, GNB1, GRB10, GRB2, HSPB1, HSPCA, HSPCB, ILK, INPP5D (SHIP), INPPL1, MAPK8IP1(JIP1), MTCP1, PDK2, PDPK1, PIK3CA (p110a), PIK3CB (p110b), PIK3CG, PIK3R1(p85a), PIK3R2 (p85b), PIK3R3, PRKCA, PRKCB1, PRKCZ, PTEN, TCL1A, TCL1B.

IGF-1 Signaling Pathway: CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CB, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF.

Inactivation of Gsk3 and the Accumulation of β-Catenin: ADAR, AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, CUTL1, EIF2AK2, FZD1, GJA1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDK1, PR48, TIRAP, TLR4, TOLLIP, WNT1, ZFYVE21.

PI3K Subunit p85 Genes and Regulation of Actin Organization and Cell Migration: AICDA, CDC42, CUTL1, PAK1, PDGFRA, RAC1, RHOA, WASL, ZFYVE21.

PTEN Dependent Cell Cycle Arrest and Apoptosis: AKT1, CDKN1B (p27), CUTL1, FASLG, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK1, PDK2, PTEN, PTK2, RBL2, SHC1, SOS1, ZFYVE21.

BAD Phosphorylation and Anti-apoptotic Pathways: AKT1, ASAH1, BAD, CUTL1, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PRKAR1B, RAF1, RPS6KA1, SHC1, SOS1, YWHAH, ZFYVE21.

Genes Involved in the mTOR Signaling Pathway: AKT1, CUTL1, EIF3S10, EIF4A1, EIF4B, EIF4E, EIF4EBP1, EIF4G1, FKBP1A, FRAP1, MKNK1, PDK1, PDK2, PR48, PTEN, RHEB, RPS6, RPS6KB1, TSC1, TSC2, ZFYVE21.

Regulation of eIF4e and p70 S6 Kinase: AKT1, CUTL1, EIF4A1, EIF4E, EIF4EBP1 (4E-BP1), EIF4G1, FRAP1(mTOR), GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK1, PDK2, PRKCA, PTEN, RPS6KB1, ZFYVE21.

Other Genes Involved in the AKT Signaling Pathway: CASP9, CHUK, FOXO1A, MLLT7, NFKBIA.

Storage Conditions

Please check the kit components immediately after you receive this package. SABiosciences is only responsible for missing items reported within two (2) business days of receipt.

GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.

References

Cantley LC. The phosphoinositide 3-kinase pathway. Science. 2002 May 31; 296 (5573): 1655-7.
Brazil DP, Park J, Hemmings BA. PKB binding proteins. Getting in on the Akt. Cell. 2002 Nov 1; 111 (3): 293-303.
Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer. 2002 Jul; 2 (7): 489-501.
Shiojima I, Walsh K. Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res. 2002 Jun 28; 90 (12): 1243-50.
Du K, Herzig S, Kulkarni RN, Montminy M. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science. 2003 Jun 6; 300 (5625): 1574-7.