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Java Runtime Environment (JRE) Installation help

Gene Network Central uses the Java applet technology. To take advantage of the features offered by Gene Network Central, you must have the Java Runtime Environment (JRE) version 1.5 or higher installed. You can download JRE 1.5 here.

Attention Mac Users!

If you are experiencing a GNC error message that indicates that you do not have the latest version of Java, and yet are told by your Mac OS that you have the latest version of all softwares--including Java--when you run the software update tool, please be aware that the latest version of Java for your Mac OS does not guarantee that it is JRE 1.5 or higher. This occurs because newer versions of Java may not be compatible with your existing Mac OS version.

You can verify your current version of the JRE by visiting JavaTester.org. Also, quoted directly from that site:

If you are running OS X 10.4 then the safe versions of Java are 1.5.0_19 and 1.4.2_21 (download here).

If you are running OS X 10.5, then the safe versions of Java are 1.6.0_13, 1.5.0_19 and 1.4.2_21 (download here).

If neither of those situations apply to you and you have Mac OS X 10.3 or lower, you may need to upgrade your Mac OS version. Please contact Apple support for any questions you may have about this procedure.

What does the graph mean?

Molecular events between two proteins (or the two genes that encode them), can be one or more of the following categories:
  • Functional regulation, such as up-regulation or down-regulation, or transcriptional regulation;
  • Chemical modification, such as a kinase phosphorylates its substrate;
  • Physical interaction;
  • Genetics interaction;
  • Co-expression at the mRNA level (can be either positively correlated expression or negatively correlated expression);

This list might grow in the future. These events do not have to be isolated, for example, the purpose of a physical interaction can be chemical modification, and the consequence of chemical modification is activation (or inhibition) of the target. The consequence of transcriptional regulation can be "activation" of a gene, or "inhibition" of a gene, which can be observed as positively correlated expression or negatively correlated expression.

There is hardly a perfect experimental system. An experimental observation be confirmed repeatedly or be validated by a different experiment always give more confidence to scientists. Different molecular events between two biological molecules validate each other. Expressed in the same tissues, located in the same cellular compartment and involved in the same biological process adds more credibility to the observations between the two biological molecules. In the graph, this can be shown as shared association partners.

Gene Network Central (GNC) brings biomedical discoveries and predictions together, in hope to help users validate their experimental results and generate new hypothesis. It is the users' responsibility to verify the scientific accuracy of data presented by GNC. GNC does not guarantee the credibility of evidence gathered from peer-reviewed papers.

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