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Brain Cancer miRNA PCR Array

Human Mouse Rat Other Species
 
Human Brain Cancer miRNA PCR Array: MIHS-108Z
The Human Brain Cancer miScript miRNA PCR Array profiles the expression of 84 miRNAs known to alter their expression during nervous system-related carcinogenesis. This array provides cancer researchers with a convenient way to quickly analyze the miRNAs most relevant to brain and central nervous system tumorigenesis. Brain tumors, which cause uncontrolled cellular growth in the cranium or spinal column, involve any of the cell types found in the brain, such as neurons, glial cells, astrocytes, or cells of the meninges. By attenuating gene expression, miRNAs regulate many biological functions, and some, such as those in the miR-17-92 cluster, have known oncogenic properties. Expression studies of different brain tumor types have identified dysregulated miRNA; however, few are functionally linked to pathogenic mechanisms. Research into the functional consequences of miRNA dysregulation during neurocarcinogenesis may yield insights into the molecular mechanisms behind the pathogenesis of brain tumors. The array contains miRNAs with known functional consequences as well as miRNAs with a significant dysregulation but unknown function during oncogenesis. The profiling results from this array may yield insights into the molecular mechanisms behind the pathogenesis of multiple nervous system cancers. A set of controls present on this array enables data analysis using the ΔΔCT method of relative quantification, assessment of reverse transcription performance, and assessment of PCR performance. Using SYBR Green-based real-time PCR, the expression of a focused panel of miRNAs related to brain cancer can be easily and reliably analyzed with this miScript miRNA PCR Array.

miScript miRNA PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention or treatment of a disease.

96-well, 384-well ( 4 x 96 ), and Rotor-Disc 100 formats are available.
See the complete miRNA PCR Array list

 

Functional miRNA Grouping How It Works Manual & Resources Reagents & Software
 
Pathway Source References     Gene Table

Anaplastic Astrocytoma: miR-107, miR-10b-5p, miR-124-3p, miR-125b-5p, miR-127-5p, miR-129-5p, miR-137, miR-138-5p, miR-187-3p, miR-203a, miR-218-5p, miR-296-5p, miR-31-5p, miR-320a, miR-7-5p.

Glioblastoma: miR-101-3p, miR-107, miR-10b-5p, miR-124-3p, miR-128, miR-129-5p, miR-130a-3p, miR-132-3p, miR-133a, miR-133b, miR-137, miR-138-5p, miR-149-5p, miR-153, miR-16-5p, miR-181a-5p, miR-181b-5p, miR-185-5p, miR-187-3p, miR-191-5p, miR-203a, miR-21-5p, miR-210, miR-218-5p, miR-221-3p, miR-222-3p, miR-222-5p, miR-23a-3p, miR-23b-3p, miR-25-3p, miR-29b-3p, miR-31-5p, miR-323a-5p, miR-328, miR-34a-5p, miR-425-5p, miR-451a, miR-486-5p, miR-7-5p.

Glioma: miR-106b-5p, miR-10b-5p, miR-128, miR-130b-3p, miR-144-3p, miR-146b-5p, miR-148a-3p, miR-15a-5p, miR-15b-5p, miR-16-5p, miR-17-5p, miR-181a-5p, miR-181b-5p, miR-182-5p, miR-183-5p, miR-184, miR-19a-3p, miR-200a-3p, miR-20a-5p, miR-21-5p, miR-210, miR-221-3p, miR-222-3p, miR-23a-3p, miR-25-3p, miR-26a-5p, miR-27a-3p, miR-296-5p, miR-328, miR-34a-5p, miR-451a, miR-486-5p, miR-9-5p, miR-9-3p, miR-93-5p.

Medulloblastoma: miR-106b-5p, miR-124-3p, miR-125a-5p, miR-125b-5p, miR-127-5p, miR-128, miR-129-5p, miR-130a-3p, miR-130b-3p, miR-133b, miR-137, miR-138-5p, miR-148a-3p, miR-150-5p, miR-153, miR-17-92 cluster (miR-17-5p, miR-18a-5p, miR-19a-3p, miR-20a-5p, miR-19b-3p, miR-92a-3p), miR-17-3p, miR-187-3p, miR-190a, miR-191-5p, miR-203a, miR-210, miR-216a-5p, miR-217, miR-218-5p, miR-25-3p, miR-29a-3p, miR-29b-3p, miR-30b-5p, miR-30c-5p, miR-320a, miR-323a-5p, miR-324-5p, miR-326, miR-328, miR-331-5p, miR-335-5p, miR-34a-5p, miR-425-5p, miR-7-5p, miR-9-3p, miR-93-5p, miR-96-5p.

Meningioma: let-7b-5p, miR-106a-5p, miR-106b-5p, miR-125a-5p, miR-153, miR-15a-5p, miR-181a-5p, miR-185-5p, miR-19b-3p, miR-200a-3p, miR-217, miR-23b-3p, miR-26a-5p, miR-27a-3p, miR-29a-3p, miR-335-5p, miR-451a.

Neuroblastoma: let-7b-5p, miR-106a-5p, miR-107, miR-125a-5p, miR-125b-5p, miR-128, miR-129-5p, miR-137, miR-141-3p, miR-146a-5p, miR-149-5p, miR-150-5p, miR-17-3p, miR-181a-5p, miR-181b-5p, miR-184, miR-187-3p, miR-190a, miR-200a-3p, miR-216a-5p, miR-221-3p, miR-23b-3p, miR-24-3p, miR-29a-3p, miR-29b-3p, miR-29c-3p, miR-30b-5p, miR-30c-5p, miR-320a, miR-323a-5p, miR-324-5p, miR-326, miR-331-5p, miR-335-5p, miR-34a-5p, miR-9-5p, miR-92a-3p, miR-93-5p.

Retinoblastoma: miR-320a.

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Functional miRNA Grouping How It Works Manual & Resources Reagents & Software
 

What miScript miRNA PCR Arrays offer?
   Guaranteed Performance* - ready-to-use for gene expression analysis
   Time & Cost Saving - less than 30 min hands-on time to analyze 84 or 372 miRNA
   Simple Data Analysis - easy-to-use Excel-Based Data Analysis Template

Layout and Controls: miScript miRNA PCR Arrays are available in 96-well, 384-well, and Rotor-Disc 100 formats. Included on each array is a set of six normalization controls as well as controls to assess RNA recovery, reverse transcription performance, and PCR performance.

You can easily perform a PCR Array experiment in your own laboratory, or send your samples to us and take advantage of our PCR Array Gene Expression Analysis Services.

*: when using the Complete miRNA PCR Array System.

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Functional miRNA Grouping How It Works Manual & Resources Reagents & Software
 

User Manual

miScript miRNA PCR Array Handbook  (PDF)

White Paper

miRNA Profiling From Blood Challenges and Recommendations (PDF)

Data Analysis

Free miRNA PCR Array Data Analysis Software (Web & Excel based)

Required Reagents and Setup Instructions

Materials & Equipment Required for miScript miRNA PCR Products
miRNA PCR Array Instrument Setup Instructions & Protocol Files

Web Seminars

Attend a live on-line seminar hosted by an Applications Scientist about PCR

Technical Brochures

miScript PCR System Brochure (PDF)

Pathway Central

Pathway reviews and presentation-ready pathway maps

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Functional miRNA Grouping How It Works Manual & Resources Reagents & Software
 

The complete miScript miRNA PCR Array System Includes:

Data Analysis: miRNA PCR Array Data Analysis Software
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