Neurological Development & Disease miRNA PCR Array

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Mouse Neurological Development & Disease miRNA PCR Array: MIMM-107Z
The Mouse Neurological Development & Disease miScript miRNA PCR Array profiles the expression of 84 miRNAs differentially expressed during neuronal development or the progression of neurological diseases. This array provides neuroscience researchers with a convenient way to analyze the miRNAs most relevant to normal nervous system development and/or psychiatric and neurodegenerative disorder progression. Certain miRNAs, such as miR-9, promote neurodevelopment processes such as neurogenesis and synaptic plasticity. Microarray analyses of diseased brain tissues show a variety of significantly dysregulated miRNAs. However, few of these analyses have yet to focus on individual miRNA function and mechanism of action during specific disease processes. The profiling results from this array can serve as a useful marker for neuronal differentiation processes and may yield insights into the molecular mechanisms behind the pathogenesis of neurological disorders. The results can also help enhance basic neurological research since dysregulated developmental processes can lead to neurological diseases, and both often involve similar miRNA-regulated biological pathways. A set of controls present on this array enables data analysis using the ΔΔCT method of relative quantification, assessment of reverse transcription performance, and assessment of PCR performance. Using SYBR Green-based real-time PCR, the expression of a focused panel of miRNAs related to neurological research can be easily and reliably analyzed with this miScript miRNA PCR Array. miScript miRNA PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention or treatment of a disease. 96-well, 384-well ( 4 x 96 ), and Rotor-Disc 100 formats are available. See the complete miRNA PCR Array list

Functional miRNA Grouping

How It Works

Manual & Resources

Reagents & Software

Pathway Source References Gene Table

Development: miR-124-3p, miR-125b-5p, miR-132-3p, miR-134-5p, miR-138-5p, miR-9-5p.

Autistic Disorders: miR-106b-5p, miR-128-3p, miR-132-3p, miR-140-5p, miR-146b-5p, miR-148b-3p, miR-15a-5p, miR-15b-5p, miR-181d-5p, miR-193b-3p, miR-27a-3p, miR-320-3p, miR-381-3p, miR-431-5p, miR-484, miR-598-3p, miR-652-3p, miR-7a-5p, miR-93-5p.

Schizophrenia: let-7d-5p, let-7e-5p, miR-105, miR-106b-5p, miR-107-3p, miR-126-5p, miR-128-3p, miR-130a-3p, miR-138-5p, miR-152-3p, miR-15a-5p, miR-15b-5p, miR-181a-5p, miR-195a-5p, miR-20a-5p, miR-20b-5p, miR-24-3p, miR-26b-5p, miR-27a-3p, miR-29a-3p, miR-29b-3p, miR-29c-3p, miR-302a-5p, miR-302b-5p, miR-30a-5p, miR-30d-5p, miR-30e-5p, miR-33-5p, miR-338-3p, miR-346-5p, miR-381-3p, miR-409-3p, miR-455-5p, miR-484, miR-485-3p, miR-489-3p, miR-7a-5p, miR-9-3p, miR-92a-3p.

Anxiety Disorder: miR-128-3p, miR-485-5p, miR-509-3p.

Tourette’s Syndrome: miR-24-3p.

Alzheimer’s Disease: let-7b-5p, let-7c-5p, let-7d-5p, let-7e-5p, let-7i-5p, miR-101a-3p, miR-101b-3p, miR-106b-5p, miR-107-3p, miR-128-3p, miR-139-5p, miR-146a-5p, miR-151-3p, miR-15a-5p, miR-15b-5p, miR-181a-5p, miR-181c-5p, miR-194-5p, miR-19b-3p, miR-20a-5p, miR-22-3p, miR-24-3p, miR-26b-5p, miR-27a-3p, miR-28a-5p, miR-298-5p, miR-29a-3p, miR-29b-3p, miR-29c-3p, miR-30d-5p, miR-320-3p, miR-328-3p, miR-346-5p, miR-34a-5p, miR-376b-3p, miR-433-3p, miR-485-3p, miR-488-3p, miR-9-5p, miR-92a-3p, miR-93-5p, miR-98-5p.

Prion Diseases: let-7b-5p, miR-128-3p, miR-139-5p, miR-146a-5p, miR-181a-1-3p, miR-191-5p, miR-203-3p, miR-320-3p, miR-337-3p, miR-338-3p, miR-339-5p, miR-342-3p.

Huntington’s Disease: miR-124-3p, miR-132-3p, miR-135b-5p, miR-29a-3p, miR-29b-3p, miR-9-5p, miR-9-3p.

Parkinson’s Disease: miR-133b-3p, miR-433-3p, miR-7a-5p.

Spinocerebellar Ataxia 1: miR-101a-3p, miR-130a-3p, miR-19b-3p.

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Functional miRNA Grouping

How It Works

Manual & Resources

Reagents & Software

What miScript miRNA PCR Arrays offer?
   Guaranteed Performance* - ready-to-use for gene expression analysis
   Time & Cost Saving - less than 30 min hands-on time to analyze 84 or 372 miRNA
   Simple Data Analysis - easy-to-use Excel-Based Data Analysis Template

Layout and Controls: miScript miRNA PCR Arrays are available in 96-well, 384-well, and Rotor-Disc 100 formats. Included on each array is a set of six normalization controls as well as controls to assess RNA recovery, reverse transcription performance, and PCR performance.

You can easily perform a PCR Array experiment in your own laboratory, or send your samples to us and take advantage of our PCR Array Gene Expression Analysis Services.

*: when using the Complete miRNA PCR Array System.

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