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Immunopathology miRNA PCR Array

Human Mouse Rat Other Species
Rat Immunopathology miRNA PCR Array: MIRN-104Z
The Rat Immunopathology miScript miRNA PCR Array profiles the expression of 84 miRNAs differentially expressed during normal and pathological responses by the immune system. This array provides immunology researchers with a convenient way to quickly analyze the miRNAs most relevant to the function of lymphocytes and other immune cells. The miRNAs have been carefully selected based on results published in peer-reviewed journals that suggest a correlation with inflammation, leukemia, lymphoma, autoimmune disorders, or other immune responses. Other miRNAs included on the array have been shown to functionally target specific transcripts encoding cytokines, other immunological regulatory proteins, and immune response signaling pathway components. The profiling results from this array can serve as a useful molecular marker for the study of normal and disease-associated immune responses. The results may also provide a deeper understanding of the molecular mechanisms regulating immunological gene expression by miRNA. A set of controls present on this array enables data analysis using the ΔΔCT method of relative quantification, assessment of reverse transcription performance, and assessment of PCR performance. Using SYBR Green-based real-time PCR, the expression of a focused panel of miRNAs related to immunopathology can be easily and reliably analyzed with this miScript miRNA PCR Array..

miScript miRNA PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention or treatment of a disease.

96-well, 384-well ( 4 x 96 ), and Rotor-Disc 100 formats are available.

See the complete miRNA PCR Array list


Functional miRNA Grouping How It Works Manual & Resources Reagents & Software
Pathway Source References     Gene Table

Leukemia & Lymphoma:
Hodgkin’s Lymphoma: miR-126a-3p, miR-128-3p, miR-129-5p, miR-130a-3p, miR-132-3p, miR-134-5p, miR-138-5p, miR-140-5p, miR-142-3p, miR-142-5p, miR-145-5p, miR-147, miR-15b-5p, miR-181a-5p, miR-183-5p, miR-185-5p, miR-200a-3p, miR-205, miR-20b-5p, miR-21-5p, miR-23b-3p, miR-26a-5p, miR-26b-5p, miR-27a-3p, miR-28-5p, miR-29b-3p, miR-30c-5p, miR-31a-5p, miR-323-3p, miR-325-5p, miR-34a-5p, miR-34c-5p, miR-9a-5p.
Primary Effusion Lymphoma: miR-103-3p, miR-140-5p, miR-142-3p, miR-152-3p, miR-16-5p, miR-17-5p, miR-182, miR-186-5p, miR-191a-5p, miR-194-5p, miR-19a-3p, miR-210-3p, miR-23b-3p, miR-26a-5p, miR-29b-3p, miR-30e-5p, miR-320-3p, miR-331-3p, miR-34a-5p.
T-cell Leukemia: miR-132-3p, miR-19b-3p, miR-20b-5p, miR-363-3p.

Autoimmune Disorders:
Idiopathic Thrombocytopenic Purpura: miR-17-5p, miR-196a-5p, miR-214-3p, miR-296-3p, miR-298-5p, miR-383-5p, miR-409a-3p.
Systemic Lupus Erythematosus: miR-17-5p, miR-142-3p, miR-184, miR-196a-5p, miR-21-5p, miR-298-5p, miR-383-5p, miR-409a-3p.

Inflammatory Responses:
IL-1 Induced Inflammatory Response: miR-146a-5p, miR-146b-5p, miR-195-5p, miR-26b-5p, miR-296-3p, miR-299a-5p.
Inflammation Mediators: miR-203a-3p.
Macrophage Inflammatory Response: miR-132-3p.
Vascular Inflammation: miR-126a-3p, miR-21-5p.
Others: miR-125a-5p, miR-125b-5p.

Innate Immune Response: miR-105, miR-146a-5p, miR-146b-5p, miR-19a-3p, miR-19b-3p, miR-299a-5p.

Induced in Monocytes by LPS: let-7e-5p, miR-132-3p, miR-146a-5p, miR-146b-5p, miR-9a-5p, miR-99b-5p.

Immune Cells:
B Cell Differentiation: miR-150-5p.
Invariant Natural Killer Cell Development: miR-150-5p.
Lymphocytes: let-7e-5p, miR-125a-5p, miR-125b-5p, miR-142-5p, miR-143-3p, miR-145-5p, miR-146a-5p, miR-195-5p, miR-206-3p, miR-207, miR-223-3p, miR-451-5p, miR-493-3p, miR-672-5p.
Monocytopoiesis: miR-17-5p, miR-20a-5p.
Natural Regulatory T Cells: miR-103-3p, miR-142-5p, miR-150-5p, miR-15b-5p, miR-16-5p, miR-191a-5p, miR-19a-3p, miR-21-5p, miR-214-3p, miR-223-3p, miR-26a-5p, miR-27b-3p, miR-29c-3p, miR-30b-5p, miR-30c-5p, miR-30e-5p.
Th2 Cells: miR-126a-3p.

Regulates Relevant Genes:
Cytokines: miR-98-5p.
Interferons & Receptors: miR-146a-5p, miR-223-3p.
Interleukins: miR-146a-5p, miR-181a-5p, miR-223-3p, miR-223-3p.
STAT3: miR-18a-5p, miR-19a-3p, miR-19b-3p, miR-20a-5p.

Signal Transduction:
IL6 / STAT3 Signaling: let-7a-5p, let-7c-5p, let-7d-5p, let-7f-5p, miR-17-5p, miR-21-5p.
NFKB Signaling: miR-146a-5p.

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Functional miRNA Grouping How It Works Manual & Resources Reagents & Software

What miScript miRNA PCR Arrays offer?
   Guaranteed Performance* - ready-to-use for gene expression analysis
   Time & Cost Saving - less than 30 min hands-on time to analyze 84 or 372 miRNA
   Simple Data Analysis - easy-to-use Excel-Based Data Analysis Template

Layout and Controls: miScript miRNA PCR Arrays are available in 96-well, 384-well, and Rotor-Disc 100 formats. Included on each array is a set of six normalization controls as well as controls to assess RNA recovery, reverse transcription performance, and PCR performance.

You can easily perform a PCR Array experiment in your own laboratory, or send your samples to us and take advantage of our PCR Array Gene Expression Analysis Services.

*: when using the Complete miRNA PCR Array System.

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Functional miRNA Grouping How It Works Manual & Resources Reagents & Software

User Manual

miScript miRNA PCR Array Handbook  (PDF)

White Paper

miRNA Profiling From Blood – Challenges and Recommendations (PDF)

Data Analysis

Free miRNA PCR Array Data Analysis Software (Web & Excel based)

Required Reagents and Setup Instructions

Materials & Equipment Required for miScript miRNA PCR Products
miRNA PCR Array Instrument Setup Instructions & Protocol Files

Web Seminars

Attend a live on-line seminar hosted by an Applications Scientist about PCR

Technical Brochures

miScript PCR System Brochure (PDF)

Pathway Central

Pathway reviews and presentation-ready pathway maps

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Functional miRNA Grouping How It Works Manual & Resources Reagents & Software

The complete miScript miRNA PCR Array System Includes:

Data Analysis: miRNA PCR Array Data Analysis Software
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