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Ovarian Cancer miRNA PCR Array

Human Mouse Rat Other Species
 
Rat Ovarian Cancer miRNA PCR Array: MIRN-110Z
The Rat Ovarian Cancer miScript miRNA PCR Array profiles the expression of 84 miRNAs known to alter their expression during ovarian cancer initiation and progression. This array provides cancer researchers with a convenient way to quickly analyze the miRNAs most relevant to ovarian tumorigenesis. Ovarian cancer has the highest mortality rate of all gynecological cancers, partly because it is often discovered at a late stage of progression. Ninety percent of ovarian tumors occur in the ovary epithelium. Epithelial ovarian cancers are divided histologically into several classes; the most common class (40%) is serous. Microarray analyses of miRNA expression have discovered potential biomarkers of ovarian cancer progression, and many results have been followed up with functional studies, which have identified potential specific oncogenic mechanisms. This array includes miRNAs shown via microarray and functional analyses to be involved specifically in serous ovarian cancer, broadly in epithelial ovarian cancer, or in ovarian cancers in general. The profiling results from this array may yield insights into the molecular mechanisms behind the pathogenesis of ovarian cancer. A set of controls present on this array enables data analysis using the ΔΔCT method of relative quantification, assessment of reverse transcription performance, and assessment of PCR performance. Using SYBR Green-based real-time PCR, the expression of a focused panel of miRNAs related to ovarian cancer can be easily and reliably analyzed with this miScript miRNA PCR Array.

miScript miRNA PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention or treatment of a disease.

96-well, 384-well ( 4 x 96 ), and Rotor-Disc 100 formats are available.

See the complete miRNA PCR Array list

 

Functional miRNA Grouping How It Works Manual & Resources Reagents & Software
 
Pathway Source References     Gene Table

Serous Ovarian Cancer:
Upregulated: miR-141-3p, miR-16-5p, miR-200a-3p, miR-200b-3p, miR-200c-3p, miR-21-5p, miR-23a-3p, miR-23b-3p, miR-27a-3p, miR-429, miR-93-5p.
Downregulated: let-7b-5p, miR-100-5p, miR-10b-5p, miR-125b-5p, miR-143-3p, miR-145-5p, miR-214-3p, miR-215, miR-26a-5p, miR-29a-3p, miR-34b-5p, miR-99a-5p.
Regulated: miR-192-5p, miR-199a-3p.

Epithelial Ovarian Cancer:
Upregulated: miR-141-3p, miR-182, miR-195-5p, miR-199a-3p, miR-200a-3p, miR-200c-3p, miR-203a-3p, miR-205, miR-21-5p, miR-26a-5p.
Downregulated: let-7a-5p, let-7b-5p, let-7c-5p, let-7d-5p, let-7i-5p, miR-1-3p, miR-100-5p, miR-125b-1-3p, miR-125b-5p, miR-126a-3p, miR-133a-3p, miR-140-5p, miR-143-3p, miR-145-5p, miR-152-3p, miR-204-5p, miR-22-3p, miR-221-3p, miR-222-3p, miR-224-5p, miR-29a-3p, miR-29b-3p, miR-29c-3p, miR-30a-5p, miR-30a-3p, miR-34b-5p, miR-346, miR-365-3p, miR-375-3p, miR-376a-3p, miR-377-3p, miR-379-5p, miR-410-3p, miR-448-3p, miR-488-3p, miR-495, miR-9a-5p, miR-99a-5p.
Regulated: miR-101a-3p, miR-103-3p, miR-105, miR-134-5p, miR-137-3p, miR-147, miR-154-5p, miR-154-3p, miR-184, miR-199a-5p, miR-200b-3p, miR-211-5p, miR-214-3p.

Ovarian Cancer:
Upregulated: miR-125b-1-3p, miR-140-5p, miR-152-3p, miR-196a-5p, miR-199a-3p, miR-199a-5p, miR-200b-3p, miR-200c-3p, miR-214-3p, miR-22-3p, miR-221-3p, miR-223-3p, miR-29a-3p, miR-29c-3p, miR-30a-5p, miR-30e-5p, miR-365-3p, miR-487b-3p, miR-99a-5p.
Downregulated: let-7a-5p, let-7b-5p, let-7c-5p, let-7d-5p, let-7i-5p, miR-125b-5p, miR-134-5p, miR-154-3p, miR-183-5p, miR-195-5p, miR-203a-3p, miR-206-3p, miR-21-5p, miR-380-3p, miR-381-3p, miR-346, miR-493-3p, miR-542-3p.
Regulated: miR-100-5p, miR-106b-5p, miR-138-5p, miR-141-3p, miR-142-5p, miR-190a-5p, miR-200a-3p, miR-222-3p, miR-34b-5p.

miRNAs with Known Functions in Ovarian Cancer: let-7i-5p, miR-100-5p, miR-10b-5p, miR-125b-5p, miR-126a-3p, miR-133a-3p, miR-140-5p, miR-141-3p, miR-152-3p, miR-16-5p, miR-182, miR-196a-5p, miR-199a-3p, miR-200b-3p, miR-200c-3p, miR-204-5p, miR-205, miR-206-3p, miR-21-5p, miR-22-3p, miR-221-3p, miR-222-3p, miR-224-5p, miR-27a-3p, miR-29a-3p, miR-30a-3p, miR-30e-5p, miR-34b-5p, miR-375-3p, miR-376a-3p, miR-410-3p, miR-429, miR-487b-3p, miR-493-3p, miR-93-5p.

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Functional miRNA Grouping How It Works Manual & Resources Reagents & Software
 

What miScript miRNA PCR Arrays offer?
   Guaranteed Performance* - ready-to-use for gene expression analysis
   Time & Cost Saving - less than 30 min hands-on time to analyze 84 or 372 miRNA
   Simple Data Analysis - easy-to-use Excel-Based Data Analysis Template

Layout and Controls: miScript miRNA PCR Arrays are available in 96-well, 384-well, and Rotor-Disc 100 formats. Included on each array is a set of six normalization controls as well as controls to assess RNA recovery, reverse transcription performance, and PCR performance.

You can easily perform a PCR Array experiment in your own laboratory, or send your samples to us and take advantage of our PCR Array Gene Expression Analysis Services.

*: when using the Complete miRNA PCR Array System.

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Functional miRNA Grouping How It Works Manual & Resources Reagents & Software
 

User Manual

miScript miRNA PCR Array Handbook  (PDF)

White Paper

miRNA Profiling From Blood Challenges and Recommendations (PDF)

Data Analysis

Free miRNA PCR Array Data Analysis Software (Web & Excel based)

Required Reagents and Setup Instructions

Materials & Equipment Required for miScript miRNA PCR Products
miRNA PCR Array Instrument Setup Instructions & Protocol Files

Web Seminars

Attend a live on-line seminar hosted by an Applications Scientist about PCR

Technical Brochures

miScript PCR System Brochure (PDF)

Pathway Central

Pathway reviews and presentation-ready pathway maps

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Functional miRNA Grouping How It Works Manual & Resources Reagents & Software
 

The complete miScript miRNA PCR Array System Includes:

Data Analysis: miRNA PCR Array Data Analysis Software
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