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Tumor Suppressor miRNAs PCR Array

Human Mouse Rat Other Species
 
Rat Tumor Suppressor miRNAs PCR Array: MIRN-119Z
The Rat Tumor Suppressor miRNAs miScript miRNA PCR Array profiles the expression of 84 miRNAs that have been identified as tumor suppressor miRNAs. Oncogenes activate carcinogenic processes such as cell cycle progression, invasion, and metastasis. These genes commonly function in signaling pathways such as RAS as well as epigenetic regulation. Tumor suppressor genes (TSGs) counteract oncogenes by inhibiting these oncogenic processes, and their expression is often downregulated in tumors. Therefore, miRNAs that inhibit tumorigenesis or target oncogenes are considered tumor suppressor miRNAs. Depending on the type of cancer under study, some TSGs can also act as oncogenes. This array provides cancer researchers with a convenient way to quickly analyze the tumor suppressor miRNAs most relevant to a wide variety of cancers. Profiling the expression of these miRNAs in tumor samples may facilitate their correlation with biological phenotypes or clinical outcomes like staging, therapy selection, metastasis, recurrence, and survival rate. A set of controls present on each array enables data analysis using the ΔΔCT method of relative quantification, assessment of reverse transcription performance, and assessment of PCR performance. Using SYBR Green real-time PCR, the expression of a focused panel of miRNAs related to tumor suppression can be easily and reliably analyzed with this miScript miRNA PCR Array.

miScript miRNA PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention or treatment of a disease.

96-well, 384-well ( 4 x 96 ), and Rotor-Disc 100 formats are available.

See the complete miRNA PCR Array list

 

Functional miRNA Grouping How It Works Manual & Resources Reagents & Software
 
Pathway Source References     Gene Table

miRNAs that Regulate Common Oncogene Classes:
Apoptosis: let-7a-5p, miR-122-5p, miR-125b-5p, miR-141-3p, miR-143-3p, miR-153-3p, miR-16-5p, miR-181a-5p, miR-181b-5p, miR-181c-5p, miR-181d-5p, miR-192-5p, miR-195-5p, miR-200c-3p, miR-22-3p, miR-29a-3p, miR-29b-3p, miR-29c-3p, miR-30a-5p, miR-30c-5p, miR-322-5p, miR-34a-5p, miR-34c-5p, miR-497-5p, miR-7a-5p. Epigenetic Regulation: miR-101a-3p, miR-124-3p, miR-126a-3p, miR-132-3p, miR-137-3p, miR-138-5p, miR-140-5p, miR-143-3p, miR-148b-3p, miR-152-3p, miR-185-5p, miR-214-3p, miR-25-3p, miR-26a-5p, miR-26b-5p, miR-27b-3p, miR-29a-3p, miR-29b-3p, miR-29c-3p, miR-708-5p. Transcriptional Regulation: miR-124-3p, miR-128-3p, miR-145-5p, miR-185-5p, miR-200a-3p, miR-214-3p, miR-25-3p. Immune Regulation: let-7d-5p, let-7e-5p, let-7f-5p, miR-98-5p. Tyrosine Kinases: let-7a-5p, let-7b-5p, miR-100-5p, miR-125a-5p, miR-125b-5p, miR-128-3p, miR-133a-3p, miR-133b-3p, miR-135a-5p, miR-137-3p, miR-139-5p, miR-140-5p, miR-146a-5p, miR-150-5p, miR-18a-5p, miR-193-3p, miR-196b-5p, miR-206-3p, miR-218a-5p, miR-223-3p, miR-23b-3p, miR-24-3p, miR-27b-3p, miR-29a-3p, miR-34a-5p, miR-34c-5p, miR-449a-5p, miR-542-5p, miR-7a-5p, miR-99a-5p. G-protein Signaling: let-7a-5p, let-7b-5p, let-7c-5p, let-7i-5p, miR-126a-3p, miR-129-5p, miR-134-5p, miR-142-3p, miR-143-3p, miR-145-5p, miR-181c-5p, miR-193-3p, miR-196b-5p, miR-96-5p. Other Oncogenes: miR-370-3p.

miRNAs also Considered Oncogenes: miR-122-5p, miR-146a-5p, miR-29a-3p, miR-29b-3p, miR-29c-3p, miR-34a-5p.

Bioinformatically Predicted miRNAs: let-7a-1-3p, let-7b-3p, let-7f-1-3p, miR-449c-5p, miR-98-3p.

Other miRNAs: miR-127-3p, miR-296-5p, miR-335, miR-874-3p.

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Functional miRNA Grouping How It Works Manual & Resources Reagents & Software
 

What miScript miRNA PCR Arrays offer?
   Guaranteed Performance* - ready-to-use for gene expression analysis
   Time & Cost Saving - less than 30 min hands-on time to analyze 84 or 372 miRNA
   Simple Data Analysis - easy-to-use Excel-Based Data Analysis Template

Layout and Controls: miScript miRNA PCR Arrays are available in 96-well, 384-well, and Rotor-Disc 100 formats. Included on each array is a set of six normalization controls as well as controls to assess RNA recovery, reverse transcription performance, and PCR performance.

You can easily perform a PCR Array experiment in your own laboratory, or send your samples to us and take advantage of our PCR Array Gene Expression Analysis Services.

*: when using the Complete miRNA PCR Array System.

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Functional miRNA Grouping How It Works Manual & Resources Reagents & Software
 

User Manual

miScript miRNA PCR Array Handbook  (PDF)

White Paper

miRNA Profiling From Blood Challenges and Recommendations (PDF)

Data Analysis

Free miRNA PCR Array Data Analysis Software (Web & Excel based)

Required Reagents and Setup Instructions

Materials & Equipment Required for miScript miRNA PCR Products
miRNA PCR Array Instrument Setup Instructions & Protocol Files

Web Seminars

Attend a live on-line seminar hosted by an Applications Scientist about PCR

Technical Brochures

miScript PCR System Brochure (PDF)

Pathway Central

Pathway reviews and presentation-ready pathway maps

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Functional miRNA Grouping How It Works Manual & Resources Reagents & Software
 

The complete miScript miRNA PCR Array System Includes:

Data Analysis: miRNA PCR Array Data Analysis Software
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