Glutathione peroxidase 4
Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, proteins are produced that localize to the nucleus, mitochondrion, and cytoplasm. The exact cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified.