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RT² Profiler PCR Arrays RT² miRNA PCR Arrays
RT² qPCR Assays RT² SYBR Green qPCR Master Mixes
Oligo GEArray DNA Microarrays SureSilencing shRNA Plasmids
Service Core for Gene Expression and Genomic Analysis EpiTect ChIP qPCR
ELISArray Kits Cignal™ Reporter Assay System
EpiTect Methyl qPCR Arrays & Assays Cignal™ Finder Reporter Arrays
XpressRef Human Universal Total RNA RT² First Strand Kit
RT² qPCR-Grade RNA isolation kit SureSilencing siRNA
SureFECT?Transfection Reagent CASE Kits
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RT² Profiler PCR Arrays

Angiogenesis
Airoldi I, Di Carlo E, Cocco C, Taverniti G, D'Antuono T, Ognio E, Watanabe M, Ribatti D, Pistoia V. Endogenous IL-12 triggers an antiangiogenic program in melanoma cells. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3996-4001. Epub 2007 Feb 23 PUBMED
Basile DP, Fredrich K, Chelladurai B, Leonard EC, Parrish AR Renal ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1, a novel VEGF inhibitor. Am J Physiol Renal Physiol. 2008 Apr;294(4):F928-36. Epub 2008 Feb 13. PUBMED
Rangel-Moreno J, Hartson L, Navarro C, Gaxiola M, Selman M, Randall TD. Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis. J Clin Invest. 2006 Dec;116(12):3183-94. PUBMED
van Beem RT, Noort WA, Voermans C, Kleijer M, ten Brinke A, van Ham SM, van der Schoot CE, Zwaginga JJ The presence of activated CD4(+) T cells is essential for the formation of colony-forming unit-Endothelial cells by CD14(+) Cells. J Immunol. 2008 Apr 1;180(7):5141-8 PUBMED
Brant KA, Fabisiak JP Nickel and the microbial toxin, MALP-2, stimulate proangiogenic mediators from human lung fibroblasts via a HIF-1alpha and COX-2-mediated pathway. Toxicol Sci. 2009 Jan;107(1):227-37. Epub 2008 Oct 1 PUBMED
Liu Z, Kobayashi K, van Dinther M, van Heiningen SH, Valdimarsdottir G, van Laar T, Scharpfenecker M, Lowik CW, Goumans MJ, Ten Dijke P, Pardali E. VEGF and inhibitors of TGFbeta type-I receptor kinase synergistically promote J Cell Sci. 2009 Sep 15;122(Pt 18):3294-302. Epub 2009 Aug 25.PUBMED
McElroy MK, Kaushal S, Tran Cao HS, Moossa AR, Talamini MA, Hoffman RM, Bouvet M. Upregulation of thrombospondin-1 and angiogenesis in an aggressive human Mol Cancer Ther. 2009 Jul;8(7):1779-86. Epub 2009 Jul 7.PUBMED
Atmaca H, Gorumlu G, Karaca B, Degirmenci M, Tunali D, Cirak Y, Purcu DU, Uzunoglu S, Karabulut B, Sanli UA, Uslu R. Combined gossypol and zoledronic acid treatment results in synergistic induction of cell death and regulates angiogenic molecules in ovarian cancer cells. Eur Cytokine Netw. 2009 Sep;20(3):121-30.PUBMED
Wang R, Chadalavada K, Wilshire J, Kowalik U, Hovinga KE, Geber A, Fligelman B, Leversha M, Brennan C, Tabar V. Glioblastoma stem-like cells give rise to tumour endothelium. Nature. 2010 Dec 9;468(7325):829-33.PUBMED
Apoptosis
Dickson EW, Hogrefe CP, Ludwig PS, Ackermann LW, Stoll LL, Denning GM Exercise Enhances Myocardial Ischemic Tolerance via an Opioid Receptor-Dependent Mechanism. Am J Physiol Heart Circ Physiol. 2007 Oct 19; [Epub ahead of print] PUBMED
Lai YM, Mohammed KA, Nasreen N, Baumuratov A, Bellew BF, Antony VB. Induction of cell cycle arrest and apoptosis by BCG infection in cultured human bronchial airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007 Aug;293(2):L393-401. Epub 2007 May 25. PUBMED
Raeder S, Utheim TP, Utheim OA, Nicolaissen B, Roald B, Cai Y, Haug K, Kvalheim A, Messelt EB, Drolsum L, Reed JC, Lyberg T. Effects of organ culture and Optisol-GS storage on structural integrity, phenotypes, and apoptosis in cultured corneal epithelium. Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5484-93 PUBMED
Zhan Q, Signoretti S, Whitaker-Menezes D, Friedman TM, Korngold R, Murphy GF. Cytokeratin15-positive basal epithelial cells targeted in graft-versus-host disease express a constitutive antiapoptotic phenotype. J Invest Dermatol. 2007 Jan;127(1):106-15. Epub 2006 Oct 12. PUBMED
Mayoral R, Moll?B, Flores JM, Bosc?L, Casado M, Mart韓 Sanz P. Constitutive expression of cyclooxygenase 2 transgene in hepatocytes protects against liver injury. Biochem J. 2008 Aug 1. [Epub ahead of print] PUBMED
McEuen JG, Beck SG, Bale TL. Failure to mount adaptive responses to stress results in dysregulation and cell death in the midbrain raphe J Neurosci. 2008 Aug 13;28(33):8169-77 PUBMED
Bose RN, Maurmann L, Mishur RJ, Yasui L, Gupta S, Grayburn WS, Hofstetter H, Milton T. Non-DNA-binding platinum anticancer agents: Cytotoxic activities of platinum-phosphato complexes towards human ovarian cancer cells. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18314-9. Epub 2008 Nov 19 PUBMED
Uetani T, Nakayama H, Okayama H, Okura T, Higaki J, Inoue H, Higashiyama S. Insufficiency of proHB-EGF shedding enhances hypoxic cell death in H9c2 cardiomyoblasts via the activation of Caspase-3 and c-JUN N-terminal kinase. J Biol Chem. 2009 Feb 4. [Epub ahead of print] PUBMED
Bok K, Prikhodko VG, Green KY, Sosnovtsev SV. Apoptosis in Murine Norovirus Infected RAW264.7 Cells is Associated with Survivin Downregulation. J Virol. 2009 Feb 11. [Epub ahead of print] PUBMED
Mhyre AJ, Marcondes AM, Spaulding EY, Deeg HJ. Stroma-dependent apoptosis in clonal hematopoietic precursors correlates with expression of PYCARD. Blood. 2009 Jan 15;113(3):649-58. Epub 2008 Oct 22 PUBMED
Pru JK, Kaneko-Tarui T, Jurisicova A, Kashiwagi A, Selesniemi K, Tilly JL. Induction of proapoptotic gene expression and recruitment of p53 herald ovarian Reprod Sci. 2009 Apr;16(4):347-56. Epub 2008 Dec 15.PUBMED
Yoshida T, Zhang Y, Rosado LA, Zhang B. Repeated treatment with subtoxic doses of TRAIL induces resistance to apoptosis through its death receptors in MDA-MB-231 breast cancer cells. Mol Cancer Res. 2009 Nov;7(11):1835-44. Epub 2009 Oct 20.PUBMED
Fischer KM, Cottage CT, Wu W, Din S, Gude NA, Avitabile D, Quijada P, Collins BL, Fransioli J, Sussman MA. Enhancement of myocardial regeneration through genetic engineering of cardiac progenitor cells expressing Pim-1 kinase. Circulation. 2009 Nov 24;120(21):2077-87. Epub 2009 Nov 9.PUBMED
Triana-Baltzer GB, Babizki M, Chan MC, Wong AC, Aschenbrenner LM, Campbell ER, Li QX, Chan RW, Peiris JS, Nicholls JM, Fang F. DAS181, a sialidase fusion protein, protects human airway epithelium against influenza virus infection: an in vitro pharmacodynamic analysis. J Antimicrob Chemother. 2010 Feb;65(2):275-84. Epub 2009 Nov 26.PUBMED
Belser JA, Zeng H, Katz JM, Tumpey TM. Cell death gene expression profile: role of RIPK2 in dengue virus-mediated apoptosis. Virus Res. 2011 Mar;156(1-2):25-34PUBMED
Atherosclerosis
Manning-Tobin JJ, Moore KJ, Seimon TA, Bell SA, Sharuk M, Alvarez-Leite JI, de Winther MP, Tabas I, Freeman MW. Loss of SR-A and CD36 Activity Reduces Atherosclerotic Lesion Complexity Without Abrogating Foam Cell Formation in Hyperlipidemic Mice. Arterioscler Thromb Vasc Biol. 2008 Oct 23. [Epub ahead of print] PUBMED
Autophgy
Belser JA, Zeng H, Katz JM, Tumpey TM. Cell death gene expression profile: role of RIPK2 in dengue virus-mediated apoptosis. Virus Res. 2011 Mar;156(1-2):25-34 PUBMED
Breast Cancer & Estrogen Receptor Signaling
Cooper C, Guo J, Yan Y, Chooniedass-Kothari S, Hube F, Hamedani MK, Murphy LC, Myal Y, Leygue E. Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Nucleic Acids Res. 2009 Jul;37(13):4518-31. Epub 2009 May 29.PUBMED
Adams BD, Cowee DM, White BA. The role of miR-206 in the epidermal growth factor (EGF) induced repression of Mol Endocrinol. 2009 Aug;23(8):1215-30. Epub 2009 May 7.PUBMED
Cancer Pathway Finder
Gridley DS, Slater JM, Luo-Owen X, Rizvi A, Chapes SK, Stodieck LS, Ferguson VL, Pecaut MJ. Spaceflight effects on T lymphocyte distribution, function and gene expression. J Appl Physiol. 2009 Jan;106(1):194-202. Epub 2008 Nov 6. PUBMED
Das KK, Bajpai M, Kong Y, Liu J, Geng X, Das KM. Mesalamine suppresses the expression of TC22, a novel tropomyosin isoform Mol Pharmacol. 2009 Jul;76(1):183-91. Epub 2009 Apr 15.PUBMED
Cell Cycle
Chen N, Ye XC, Chu K, Navone NM, Sage EH, Yu-Lee LY, Logothetis CJ, Lin SH. A secreted isoform of ErbB3 promotes osteonectin expression in bone and enhances the invasiveness of prostate cancer cells. Cancer Res. 2007 Jul 15;67(14):6544-8 PUBMED
Chen S, Sims GP, Chen XX, Gu YY, Chen S, Lipsky PE. Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol. 2007 Aug 1;179(3):1634-47. PUBMED
Lu SY, Sontag DP, Detillieux KA, Cattini PA. FGF-16 is released from neonatal cardiac myocytes and alters growth-related signaling: a possible role in postnatal development. Am J Physiol Cell Physiol. 2008 May;294(5):C1242-9. Epub 2008 Mar 12 PUBMED
Higgins S, Wong SH, Richner M, Rowe CL, Newgreen DF, Werther GA, Russo VC. Fibroblast growth factor 2 reactivates G1 checkpoint in SK-N-MC cells via Endocrinology. 2009 Sep;150(9):4044-55. Epub 2009 May 28.PUBMED
Seifert AW, Zheng Z, Ormerod BK, Cohn MJ. Sonic hedgehog controls growth of external genitalia by regulating cell cycle kinetics. Nat Commun. 2010 Jun 1;1:23PUBMED
Chemokines & Receptors
Klopp AH, Spaeth EL, Dembinski JL, Woodward WA, Munshi A, Meyn RE, Cox JD, Andreeff M, Marini FC Tumor irradiation increases the recruitment of circulating mesenchymal stem cells into the tumor microenvironment. Cancer Res. 2007 Dec 15;67(24):11687-95. PUBMED
Miselis NR, Wu ZJ, Van Rooijen N, Kane AB Targeting tumor-associated macrophages in an orthotopic murine model of diffuse malignant mesothelioma. Mol Cancer Ther. 2008 Apr;7(4):788-99. Epub 2008 Mar 28 PUBMED
Sinha S, Subramanian S, Proctor TM, Kaler LJ, Grafe M, Dahan R, Huan J, Vandenbark AA, Burrows GG, Offner H. A promising therapeutic approach for multiple sclerosis: recombinant T-cell receptor ligands modulate experimental autoimmune encephalomyelitis by reducing interleukin-17 production and inhibiting migration of encephalitogenic cells into the CNS J Neurosci. 2007 Nov 14;27(46):12531-9. PUBMED
Sze SK, de Kleijn DP, Lai RC, Khia Way Tan E, Zhao H, Yeo KS, Low TY, Lian Q, Lee CN, Mitchell W, El Oakley RM, Lim SK. Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells. Mol Cell Proteomics. 2007 Oct;6(10):1680-9. Epub 2007 Jun 11. PUBMED
Lee PY, Kumagai Y, Li Y, Takeuchi O, Yoshida H, Weinstein J, Kellner ES, Nacionales D, Barker T, Kelly-Scumpia K, van Rooijen N, Kumar H, Kawai T, Satoh M, Akira S, Reeves WH. TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus. J Exp Med. 2008 Dec 22;205(13):2995-3006. Epub 2008 Dec 1 PUBMED
Lim J, Derrick SC, Kolibab K, Yang AL, Porcelli S, Jacobs WR, Morris SL. Early pulmonary cytokine and chemokine responses in mice immunized with three different vaccines against Mycobacterium tuberculosis determined by PCR array. Clin Vaccine Immunol. 2009 Jan;16(1):122-6. Epub 2008 Nov 26. PUBMED
Fukami N, Ramachandran S, Saini D, Walter M, Chapman W, Patterson GA, Mohanakumar T. Antibodies to MHC class I induce autoimmunity: role in the pathogenesis of chronic rejection. J Immunol. 2009 Jan 1;182(1):309-18. PUBMED
Cheung KP, Yang E, Goldrath AW. Memory-like CD8+ T cells generated during homeostatic proliferation defer to J Immunol. 2009 Sep 1;183(5):3364-72. Epub 2009 Aug 12.PUBMED
Sundararaj KP, Samuvel DJ, Li Y, Sanders JJ, Lopes-Virella MF, Huang Y. Interleukin-6 released from fibroblasts is essential for up-regulation of matrix J Biol Chem. 2009 May 15;284(20):13714-24. Epub 2009 Mar 23.PUBMED
Weiss JM, Back TC, Scarzello AJ, Subleski JJ, Hall VL, Stauffer JK, Chen X, Micic D, Alderson K, Murphy WJ, Wiltrout RH. Successful immunotherapy with IL-2/anti-CD40 induces the chemokine-mediated mitigation of an immunosuppressive tumor microenvironment. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19455-60. Epub 2009 Nov 5.PUBMED
Common Cytokines
Gude N, Muraski J, Rubio M, Kajstura J, Schaefer E, Anversa P, Sussman MA. Akt promotes increased cardiomyocyte cycling and expansion of the cardiac progenitor cell population. Circ Res. 2006 Aug 18;99(4):381-8. Epub 2006 Jul 13. PUBMED
Keskin DB, Allan DS, Rybalov B, Andzelm MM, Stern JN, Kopcow HD, Koopman LA, Strominger JL. TGFbeta promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cells. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3378-83. Epub 2007 Feb 20. PUBMED
Sze SK, de Kleijn DP, Lai RC, Khia Way Tan E, Zhao H, Yeo KS, Low TY, Lian Q, Lee CN, Mitchell W, El Oakley RM, Lim SK. Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells. Mol Cell Proteomics. 2007 Oct;6(10):1680-9. Epub 2007 Jun 11. PUBMED
Silver RF, Walrath J, Lee H, Jacobson BA, Horton H, Bowman MR, Nocka K, Sypek JP. Human Alveolar Macrophage Gene Responses to Mycobacterium tuberculosis Strains H37Ra and H37Rv. Am J Respir Cell Mol Biol. 2008 Sep 11. [Epub ahead of print] PUBMED
Campeau PM, Rafei M, Boivin MN, Sun Y, Grabowski GA, Galipeau J. Characterization of Gaucher disease bone marrow mesenchymal stromal cells reveals Blood. 2009 Oct 8;114(15):3181-90. Epub 2009 Jul 8.PUBMED
Myskiw C, Arsenio J, van Bruggen R, Deschambault Y, Cao J. Vaccinia virus E3 suppresses expression of diverse cytokines through inhibition J Virol. 2009 Jul;83(13):6757-68. Epub 2009 Apr 15.PUBMED
Custom
Sonic hedgehog controls growth of external genitalia by regulating cell cycle kinetics. Nat Commun. 2010 Jun 1;1:23. 2006 Aug 17; [Epub ahead of print] PUBMED
Bowers RR, Kim JW, Otto TC, Lane MD. Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: Role of the BMP-4 gene. Proc Natl Acad Sci U S A. 2006 Aug 17; [Epub ahead of print] PUBMED
Bowers RR, Kim JW, Otto TC, Lane MD. Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: Role of the BMP-4 gene. Proc Natl Acad Sci U S A. 2006 Aug 17; [Epub ahead of print] PUBMED
Torcia MG, Santarlasci V, Cosmi L, Clemente A, Maggi L, Mangano VD, Verra F, Bancone G, Nebie I, Sirima BS, Liotta F, Frosali F, Angeli R, Severini C, Sannella AR, Bonini P, Lucibello M, Maggi E, Garaci E, Coluzzi M, Cozzolino F, Annunziato F, Romagnani S, Modiano D. Functional deficit of T regulatory cells in Fulani, an ethnic group with low susceptibility to Plasmodium falciparum malaria. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):646-51. Epub 2008 Jan 3 PUBMED
Shivapurkar N, Stastny V, Okumura N, Girard L, Xie Y, Prinsen C, Thunnissen FB, Wistuba II, Czerniak B, Frenkel E, Roth JA, Liloglou T, Xinarianos G, Field JK, Minna JD, Gazdar AF. Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene. Cancer Res. 2008 Sep 15;68(18):7448-56. PUBMED
Bousquet L, Pruvost A, Guyot AC, Farinotti R, Mabondzo A. Combination of Tenofovir and Emtricitabine plus Efavirenz: In Vitro Modulation of ABC transporter and Intracellular Drug Accumulation. Antimicrob Agents Chemother. 2008 Dec 15. [Epub ahead of print] PUBMED
Bousquet L, Pruvost A, Guyot AC, Farinotti R, Mabondzo A. Combination of Tenofovir and Emtricitabine plus Efavirenz: In Vitro Modulation of ABC transporter and Intracellular Drug Accumulation. Antimicrob Agents Chemother. 2008 Dec 15. [Epub ahead of print] PUBMED
Huang J, Chen K, Huang J, Gong W, Dunlop NM, Howard OM, Bian X, Gao Y, Wang JM. Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation. Carcinogenesis. 2009 Feb;30(2):348-55. Epub 2008 Nov 26 PUBMED
Chahrour M, Jung SY, Shaw C, Zhou X, Wong ST, Qin J, Zoghbi HY. MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription Science. 2008 May 30;320(5880):1224-9. PUBMED
Yamamoto H, Shigematsu H, Nomura M, Lockwood WW, Sato M, Okumura N, Soh J, Suzuki M, Wistuba II, Fong KM, Lee H, Toyooka S, Date H, Lam WL, Minna JD, Gazdar AF. PIK3CA mutations and copy number gains in human lung cancers. Cancer Res. 2008 Sep 1;68(17):6913-21. PUBMED
Birrell MA, De Alba J, Catley MC, Hardaker E, Wong S, Collins M, Clarke DL, Farrow SN, Willson TM, Collins JL, Belvisi MG. Liver X receptor agonists increase airway reactivity in a model of asthma via increasing airway smooth muscle growth. J Immunol. 2008 Sep 15;181(6):4265-71. PUBMED
Peduto L, Dulauroy S, Lochner M, Spath GF, Morales MA, Cumano A, Eberl G. Inflammation recapitulates the ontogeny of lymphoid stromal cells. J Immunol. 2009 May 1;182(9):5789-99.PUBMED
Ianzini F, Kosmacek EA, Nelson ES, Napoli E, Erenpreisa J, Kalejs M, Mackey MA. Activation of meiosis-specific genes is associated with depolyploidization of Cancer Res. 2009 Mar 15;69(6):2296-304. Epub 2009 Mar 3.PUBMED
Schreiber TH, Deyev VV, Rosenblatt JD, Podack ER. Tumor-induced suppression of CTL expansion and subjugation by gp96-Ig Cancer Res. 2009 Mar 1;69(5):2026-33. Epub 2009 Feb 17.PUBMED
Peduto L, Dulauroy S, Lochner M, Spath GF, Morales MA, Cumano A, Eberl G. Inflammation recapitulates the ontogeny of lymphoid stromal cells. J Immunol. 2009 May 1;182(9):5789-99.PUBMED
DiMeo TA, Anderson K, Phadke P, Fan C, Perou CM, Naber S, Kuperwasser C. A novel lung metastasis signature links Wnt signaling with cancer cell Cancer Res. 2009 Jul 1;69(13):5364-73. Epub 2009 Jun 23.PUBMED
Chang BY, Zhao F, He X, Ren H, Braselmann S, Taylor V, Wicks J, Payan DG, Grossbard EB, Pine PR, Bullard DC. JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 J Immunol. 2009 Aug 1;183(3):2183-92. Epub 2009 Jul 13.PUBMED
Titterington JS, Sukhanov S, Higashi Y, Vaughn C, Bowers C, Delafontaine P. Growth hormone-releasing peptide-2 suppresses vascular oxidative stress in ApoE-/- mice but does not reduce atherosclerosis. Endocrinology. 2009 Dec;150(12):5478-87. Epub 2009 Oct 9.PUBMED
Yu J, Fernández-Hernando C, Suarez Y, Schleicher M, Hao Z, Wright PL, DiLorenzo A, Kyriakides TR, Sessa WC Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17511-6. Epub 2009 Sep 25.PUBMED
Chan SK, Riley PR, Price KL, McElduff F, Winyard PJ, Welham SJ, Woolf AS, Long DA. Corticosteroid-induced kidney dysmorphogenesis is associated with deregulated expression of known cystogenic molecules, as well as Indian hedgehog. Am J Physiol Renal Physiol. 2010 Feb;298(2):F346-56. Epub 2009 Dec 9.PUBMED
Bergamaschi A, David A, Le Rouzic E, Nisole S, Barré-Sinoussi F, Pancino G. The CDK inhibitor p21Cip1/WAF1 is induced by FcgammaR activation and restricts the replication of human immunodeficiency virus type 1 and related primate lentiviruses in human macrophages. J Virol. 2009 Dec;83(23):12253-65. Epub 2009 Sep 16.PUBMED
DNA Damage
Hoffman AE, Zheng T, Ba Y, Zhu Y. The circadian gene NPAS2, a putative tumor suppressor, is involved in DNA damage response. Mol Cancer Res. 2008 Sep;6(9):1461-8 PUBMED
Chesnokova V, Wong C, Zonis S, Gruszka A, Wawrowsky K, Ren SG, Benshlomo A, Yu R. Diminished pancreatic {beta} cell mass in securin-null mice is caused by {beta} cell apoptosis and senescence. Endocrinology. 2009 Feb 12. [Epub ahead of print] PUBMED
Santisteban M, Reiman JM, Asiedu MK, Behrens MD, Nassar A, Kalli KR, Haluska P, Ingle JN, Hartmann LC, Manjili MH, Radisky DC, Ferrone S, Knutson KL. Immune-induced epithelial to mesenchymal transition in vivo generates breast Cancer Res. 2009 Apr 1;69(7):2887-95. Epub 2009 Mar 10.PUBMED
Drug Metabolism: Phase I Enzymes
Ning B, Dial S, Sun Y, Wang J, Yang J, Guo L Systematic and simultaneous gene profiling of 84 drug-metabolizing genes in primary human hepatocytes J Biomol Screen. 2008 Mar;13(3):194-201. Epub 2008 Feb 12 PUBMED
ECM
Tian J, Pecaut MJ, Slater JM, Gridley DS. Spaceflight modulates expression of extracellular matrix, adhesion, and profibrotic molecules in mouse lung. J Appl Physiol. 2010 Jan;108(1):162-71. Epub 2009 Oct 22. PUBMED
Embryonic stem cells
Meyn MA 3rd, Smithgall TE. Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells. Sci Signal. 2009 Oct 13;2(92):ra64. PUBMED
Extracellular Matrix & Adhesion Molecules
Collins M, Hurford R, Chao Y, Patrick C, Langford TD. Variability in Virus and in Host During HIV-1 Infection. Horn of Africa Journal of AIDS. 2006 Volume III, Issue I:38-46. PUBMED
Gelain F, Bottai D, Vescovi A, Zhang S. Designer self-assembling Peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures. PLoS ONE. 2006 Dec 27;1:e119. PUBMED
Johansen LD, Naumanen T, Knudsen A, Westerlund N, Gromova I, Junttila M, Nielsen C, Bottzauw T, Tolkovsky A, Westermarck J, Coffey ET, Jaattela M, Kallunki T. IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration. J Cell Sci. 2008 Mar 15;121(Pt 6):854-64. Epub 2008 Feb 26. PUBMED
Nacu N, Luzina IG, Highsmith K, Lockatell V, Pochetuhen K, Cooper ZA, Gillmeister MP, Todd NW, Atamas SP Macrophages produce TGF-beta-induced (beta-ig-h3) following ingestion of apoptotic cells and regulate MMP14 levels and collagen turnover in fibroblasts J Immunol. 2008 Apr 1;180(7):5036-44 PUBMED
Oumouna-Benachour K, Hans CP, Suzuki Y, Naura A, Datta R, Belmadani S, Fallon K, Woods C, Boulares AH. Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death. Circulation. 2007 May 8;115(18):2442-50. Epub 2007 Apr 16. PUBMED PUBMED
Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H. Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9. J Biol Chem. 2008 Jul 10. [Epub ahead of print]  PUBMED
Tapia A, Salamonsen LA, Manuelpillai U, Dimitriadis E. Leukemia inhibitory factor promotes human first trimester extravillous trophoblast adhesion to extracellular matrix and secretion of tissue inhibitor of metalloproteinases-1 and -2. Hum Reprod. 2008 Aug;23(8):1724-32. Epub 2008 May 20.  PUBMED
Yen JH, Khayrullina T, Ganea D. PGE2-induced metalloproteinase-9 is essential for dendritic cell migration Blood. 2007 Oct 9; [Epub ahead of print] PUBMED PUBMED
Zauli G, Corallini F, Bossi F, Fischetti F, Durigutto P, Celeghini C, Tedesco F, Secchiero P. Osteoprotegerin increases leukocyte adhesion to endothelial cells both in vitro and in vivo. Blood. 2007 Jul 15;110(2):536-43. Epub 2007 Mar 15.  PUBMED
Zauli G, Corallini F, Bossi F, Fischetti F, Durigutto P, Celeghini C, Tedesco F, Secchiero P. Osteoprotegerin increases leukocyte adhesion to endothelial cells both in vitro and in vivo. Blood. 2007 Jul 15;110(2):536-43. Epub 2007 Mar 15. PUBMED
Lucio-Eterovic AK, Piao Y, de Groot JF. Mediators of glioblastoma resistance and invasion during antivascular endothelial Clin Cancer Res. 2009 Jul 15;15(14):4589-99. Epub 2009 Jun 30.PUBMED
Kuhn AR, Schlauch K, Lao R, Halayko AJ, Gerthoffer WT, Singer CA. MicroRNA Expression in Human Airway Smooth Muscle Cells: Role of miR-25 in Am J Respir Cell Mol Biol. 2009 Jun 18.PUBMED
Endothelial Cell Biology
Li Z, Suzuki Y, Huang M, Cao F, Xie X, Connolly AJ, Yang PC, Wu JC Comparison of Reporter Gene and Iron Particle Labeling for Tracking Fate of Human Embryonic Stem Cells and Differentiated Endothelial Cells in Living Subjects. Stem Cells. 2008 Apr;26(4):864-73. Epub 2008 Jan 24  PUBMED
Asada S, Takahashi T, Isodono K, Adachi A, Imoto H, Ogata T, Ueyama T, Matsubara H, Oh H. Downregulation of Dicer expression by serum withdrawal sensitizes human endothelial cells to apoptosis. Am J Physiol Heart Circ Physiol. 2008 Dec;295(6):H2512-21. Epub 2008 Oct 31 PUBMED
Liu Z, Kobayashi K, van Dinther M, van Heiningen SH, Valdimarsdottir G, van Laar T, Scharpfenecker M, Löwik CW, Goumans MJ, Ten Dijke P, Pardali E VEGF and inhibitors of TGFbeta type-I receptor kinase synergistically promote blood-vessel formation by inducing alpha5-integrin expression. J Cell Sci. 2009 Sep 15;122(Pt 18):3294-302. Epub 2009 Aug 25 PUBMED
Growth Factors
Stirling DP, Liu S, Kubes P, Yong VW Depletion of Ly6G/Gr-1 leukocytes after spinal cord injury in mice alters wound healing and worsens neurological outcome. J Neurosci. 2009 Jan 21;29(3):753-64. PUBMED
Dunn GA, Bale TL. Maternal high-fat diet promotes body length increases and insulin insensitivity in second-generation mice. Endocrinology. 2009 Nov;150(11):4999-5009. Epub 2009 Oct 9 PUBMED
Hypoxia Signaling
Wendler CC, Amatya S, McClaskey C, Ghatpande S, Fredholm BB, Rivkees SA. A1 adenosine receptors play an essential role in protecting the embryo against hypoxia. Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9697-702. Epub 2007 May 23 PUBMED
Mueller BR, Bale TL. Sex-specific programming of offspring emotionality after stress early in pregnancy. J Neurosci. 2008 Sep 3;28(36):9055-65. PUBMED
Inflammatory Cytokines & Receptors
Aubin E, Lemieux R, Bazin R. Absence of cytokine modulation following therapeutic infusion of intravenous immunoglobulin or anti-red blood cell antibodies in a mouse model of immune thrombocytopenic purpura. Br J Haematol. 2007 Mar;136(6):837-43. PUBMED
Dickson EW, Hogrefe CP, Ludwig PS, Ackermann LW, Stoll LL, Denning GM Exercise Enhances Myocardial Ischemic Tolerance via an Opioid Receptor-Dependent Mechanism. Am J Physiol Heart Circ Physiol. 2007 Oct 19; [Epub ahead of print] PUBMED
Lakshmanan U, Porter AG Caspase-4 interacts with TNF receptor-associated factor 6 and mediates lipopolysaccharide-induced NF-kappaB-dependent production of IL-8 and CC chemokine ligand 4 (macrophage-inflammatory protein-1 ). J Immunol. 2007 Dec 15;179(12):8480-90  PUBMED
Rangel-Moreno J, Hartson L, Navarro C, Gaxiola M, Selman M, Randall TD. Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis. J Clin Invest. 2006 Dec;116(12):3183-94. PUBMED
Sze SK, de Kleijn DP, Lai RC, Khia Way Tan E, Zhao H, Yeo KS, Low TY, Lian Q, Lee CN, Mitchell W, El Oakley RM, Lim SK. Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells. Mol Cell Proteomics. 2007 Oct;6(10):1680-9. Epub 2007 Jun 11. PUBMED
Lee JK, McCoy MK, Harms AS, Ruhn KA, Gold SJ, Tansey MG. Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory response. J Neurosci. 2008 Aug 20;28(34):8517-28. PUBMED
Chittur S, Parr B, Marcovici G. Inhibition of Inflammatory Gene Expression in Keratinocytes Using a Composition Evid Based Complement Alternat Med. 2009 Aug 19.PUBMED
Kawaguchi A, Orba Y, Kimura T, Iha H, Ogata M, Tsuji T, Ainai A, Sata T, Okamoto T, Hall WW, Sawa H, Hasegawa H. Inhibition of the SDF-1alpha-CXCR4 axis by the CXCR4 antagonist AMD3100 Blood. 2009 Oct 1;114(14):2961-8. Epub 2009 Aug 5.PUBMED
Kanda T, Steele R, Ray R, Ray RB. Inhibition of intrahepatic gamma interferon production by hepatitis C virus J Virol. 2009 Sep;83(17):8463-9. Epub 2009 Jun 24.PUBMED
Huston JM, Rosas-Ballina M, Xue X, Dowling O, Ochani K, Ochani M, Yeboah MM, Chatterjee PK, Tracey KJ, Metz CN. Cholinergic neural signals to the spleen down-regulate leukocyte trafficking via J Immunol. 2009 Jul 1;183(1):552-9.PUBMED
MacNamara KC, Racine R, Chatterjee M, Borjesson D, Winslow GM. Diminished hematopoietic activity associated with alterations in innate and Infect Immun. 2009 Sep;77(9):4061-9. Epub 2009 May 18.PUBMED
Sundararaj KP, Samuvel DJ, Li Y, Sanders JJ, Lopes-Virella MF, Huang Y. Interleukin-6 released from fibroblasts is essential for up-regulation of matrix J Biol Chem. 2009 May 15;284(20):13714-24. Epub 2009 Mar 23.PUBMED
Montgomery CP, Daum RS. Transcription of inflammatory genes in the lung after infection with Infect Immun. 2009 May;77(5):2159-67. Epub 2009 Feb 23.PUBMED
Choi K, Ahn YH, Gibbons DL, Tran HT, Creighton CJ, Girard L, Minna JD, Qin FX, Kurie JM. Distinct biological roles for the notch ligands Jagged-1 and Jagged-2. J Biol Chem. 2009 Jun 26;284(26):17766-74. Epub 2009 Apr 27.PUBMED
Rank RG, Lacy HM, Goodwin A, Sikes J, Whittimore J, Wyrick PB, Nagarajan UM. Host chemokine and cytokine response in the endocervix within the first developmental cycle of Chlamydia muridarum. Infect Immun. 2010 Jan;78(1):536-44. Epub 2009 Oct 19.PUBMED
Fox JG, Feng Y, Theve EJ, Raczynski AR, Fiala JL, Doernte AL, Williams M, McFaline JL, Essigmann JM, Schauer DB, Tannenbaum SR, Dedon PC, Weinman SA, Lemon SM, Fry RC, Rogers AB. Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens. Gut. 2010 Jan;59(1):88-97.PUBMED
Inflammatory Response and Autoimmunity
Rafei M, Campeau PM, Wu JH, Birman E, Forner K, Boivin MN, Galipeau J. Selective inhibition of CCR2 expressing lymphomyeloid cells in experimental J Immunol. 2009 Mar 1;182(5):2620-7.PUBMED
Rayner KJ, Suárez Y, Dávalos A, Parathath S, Fitzgerald ML, Tamehiro N, Fisher EA, Moore KJ, Fernández-Hernando C. Infection with highly pathogenic H7 influenza viruses results in an attenuated proinflammatory cytokine and chemokine response early after infection. J Infect Dis. 2011 Jan 1;203(1):40-8.PUBMED
Zeng H, Pappas C, Katz JM, Tumpey TM. The 2009 pandemic H1N1 and triple-reassortant swine H1N1 influenza viruses replicate efficiently but elicit an attenuated inflammatory response in polarized human bronchial epithelial cells J Virol. 2011 Jan;85(2):686-96PUBMED
Insulin Signaling
Narvaez CJ, Matthews D, Broun E, Chan M, Welsh J. Lean phenotype and resistance to diet-induced obesity in vitamin D receptor knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue. Endocrinology. 2009 Feb;150(2):651-61. Epub 2008 Oct 9 PUBMED
Interferon α, β Response
Tilton JC, Manion MM, Luskin MR, Johnson AJ, Patamawenu AA, Hallahan CW, Cogliano-Shutta NA, Mican JM, Davey RT Jr, Kottilil S, Lifson JD, Metcalf JA, Lempicki RA, Connors M. Human immunodeficiency virus viremia induces plasmacytoid dendritic cell activation in vivo and diminished alpha interferon production in vitro. J Virol. 2008 Apr;82(8):3997-4006. Epub 2008 Feb 6  PUBMED
Li Q, Xu B, Michie SA, Rubins KH, Schreriber RD, McDevitt HO. Interferon-alpha initiates type 1 diabetes in nonobese diabetic mice. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12439-44. Epub 2008 Aug 20. PUBMED
Christensen JE, Simonsen S, Fenger C, S鴕ensen MR, Moos T, Christensen JP, Finsen B, Thomsen AR. Fulminant lymphocytic choriomeningitis virus-induced inflammation of the CNS involves a cytokine-chemokine-cytokine-chemokine cascade. J Immunol. 2009 Jan 15;182(2):1079-87. PUBMED
Interferon (IFN) and Receptor
Yoshimi R, Chang TH, Wang H, Atsumi T, Morse HC 3rd, Ozato K. Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in J Immunol. 2009 Jun 15;182(12):7527-38.PUBMED
DeWitte-Orr SJ, Mehta DR, Collins SE, Suthar MS, Gale M Jr, Mossman KL. Long double-stranded RNA induces an antiviral response independent of IFN regulatory factor 3, IFN-beta promoter stimulator 1, and IFN. J Immunol. 2009 Nov 15;183(10):6545-53. Epub 2009 Oct 28. PUBMED
JAK / STAT Signaling
Albanesi C, Fairchild HR, Madonna S, Scarponi C, De Pit?O, Leung DY, Howell MD. IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3. J Immunol. 2007 Jul 15;179(2):984-92. PUBMED
Duechting A, Tschope C, Kaiser H, Lamkemeyer T, Tanaka N, Aberle S, Lang F, Torresi J, Kandolf R, Bock CT. Human Parvovirus B19 NS1 Protein Modulates Inflammatory Signaling by Activation of STAT3/PIAS3 in Human Endothelial Cells. J Virol. 2008 Jun 11. [Epub ahead of print]  PUBMED
Sze SK, de Kleijn DP, Lai RC, Khia Way Tan E, Zhao H, Yeo KS, Low TY, Lian Q, Lee CN, Mitchell W, El Oakley RM, Lim SK. Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells. Mol Cell Proteomics. 2007 Oct;6(10):1680-9. Epub 2007 Jun 11. PUBMED
Noronha AM, Liang Y, Hetzel JT, Hasturk H, Kantarci A, Stucchi A, Zhang Y, Nikolajczyk BS, Farraye FA, Ganley-Leal LM. Hyperactivated B cells in human inflammatory bowel disease. J Leukoc Biol. 2009 Oct;86(4):1007-16. Epub 2009 Jul 9.PUBMED
Torroella-Kouri M, Silvera R, Rodriguez D, Caso R, Shatry A, Opiela S, Ilkovitch D, Schwendener RA, Iragavarapu-Charyulu V, Cardentey Y, Strbo N, Lopez DM. Identification of a subpopulation of macrophages in mammary tumor-bearing mice Cancer Res. 2009 Jun 1;69(11):4800-9. Epub 2009 May 19.PUBMED
Lipoprotein Signaling & Cholesterol
Zhou C, King N, Chen KY, Breslow JL. Activation of pregnane X receptor induces hypercholesterolemia in wild-type and J Lipid Res. 2009 May 12.PUBMED
MAP Kinase Signaling
Ruettger A, Schueler S, Mollenhauer JA, Wiederanders B. Cathepsins B, K and L are regulated by a defined collagen type II peptide via activation of classical protein kinase C and p38 MAP kinase in articular chondrocytes. J Biol Chem. 2007 Nov 8; [Epub ahead of print] PUBMED
Singh S, Yin X, Pisano MM, Greene RM. Molecular profiles of mitogen activated protein kinase signaling pathways in orofacial development. Birth Defects Res A Clin Mol Teratol. 2007 Jan;79(1):35-44. PUBMED
Makarenkova HP, Hoffman MP, Beenken A, Eliseenkova AV, Meech R, Tsau C, Patel VN, Lang RA, Mohammadi M. Differential interactions of FGFs with heparan sulfate control gradient formation Sci Signal. 2009 Sep 15;2(88):ra55.PUBMED
NFκB Signaling
Chen N, Ye XC, Chu K, Navone NM, Sage EH, Yu-Lee LY, Logothetis CJ, Lin SH. A secreted isoform of ErbB3 promotes osteonectin expression in bone and enhances the invasiveness of prostate cancer cells. Cancer Res. 2007 Jul 15;67(14):6544-8. PUBMED
Chen S, Sims GP, Chen XX, Gu YY, Chen S, Lipsky PE. Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol. 2007 Aug 1;179(3):1634-47. PUBMED
Sze SK, de Kleijn DP, Lai RC, Khia Way Tan E, Zhao H, Yeo KS, Low TY, Lian Q, Lee CN, Mitchell W, El Oakley RM, Lim SK. Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells. Mol Cell Proteomics. 2007 Oct;6(10):1680-9. Epub 2007 Jun 11. PUBMED
Han YM, Romero R, Kim JS, Tarca AL, Kim SK, Draghici S, Kusanovic JP, Gotsch F, Mittal P, Hassan S, Kim CJ. Region-Specific Gene Expression Profiling: Novel Evidence for Biological Heterogeneity of the Human Amnion Biol Reprod. 2008 Aug 6. [Epub ahead of print] PUBMED
Singh K, Sinha S, Malonia SK, Bist P, Tergaonkar V, Chattopadhyay S. Tumor suppressor SMAR1 represses IkappaBalpha expression and inhibits p65 transactivation through matrix attachment regions. J Biol Chem. 2009 Jan 9;284(2):1267-78. Epub 2008 Nov 3. PUBMED
Farhana L, Dawson MI, Xu L, Fontana JA. SHP and Sin3A expression are essential for adamantyl-substituted retinoid-related Mol Cancer Ther. 2009 Jun;8(6):1625-35. Epub 2009 Jun 9.PUBMED
Oxidative Stress and Antioxidant Defense
Chua PJ, Yip GW, Bay BH. Cell cycle arrest induced by hydrogen peroxide is associated with modulation of Exp Biol Med (Maywood). 2009 Sep;234(9):1086-94. Epub 2009 Jul 13.PUBMED
Xu Y, Saegusa C, Schehr A, Grant S, Whitsett JA, Ikegami M. C/EBP{alpha} is required for pulmonary cytoprotection during hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L286-98. Epub 2009 May 22.PUBMED
Baqai FP, Gridley DS, Slater JM, Luo-Owen X, Stodieck LS, Ferguson V, Chapes SK, Pecaut MJ. Effects of spaceflight on innate immune function and antioxidant gene expression. J Appl Physiol. 2009 Jun;106(6):1935-42. Epub 2009 Apr 2.PUBMED
Chen A, Cuevas I, Kenny PA, Miyake H, Mace K, Ghajar C, Boudreau A, Bissell M, Boudreau N. Endothelial cell migration and vascular endothelial growth factor expression are Cancer Res. 2009 Aug 15;69(16):6721-9. Epub 2009 Aug 4.PUBMED
Polytarchou C, Pfau R, Hatziapostolou M, Tsichlis PN The JmjC domain histone demethylase Ndy1 regulates redox homeostasis and protects cells from oxidative stress. Mol Cell Biol. 2008 Dec;28(24):7451-64. Epub 2008 Oct 6 PUBMED
Osteogenesis
Gouttenoire J, Valcourt U, Bougault C, Aubert-Foucher E, Arnaud E, Giraud L, Mallein-Gerin F. Knockdown of the intraflagellar transport protein IFT46 stimulates selective gene expression in mouse chondrocytes and affects early development in zebrafish. J Biol Chem. 2007 Oct 19;282(42):30960-73. Epub 2007 Aug 24  PUBMED
Wescott DC, Pinkerton MN, Gaffey BJ, Beggs KT, Milne TJ, Meikle MC. Osteogenic gene expression by human periodontal ligament cells under cyclic tension. J Dent Res. 2007 Dec;86(12):1212-6  PUBMED
Flowers S, Nagl NG Jr, Beck GR Jr, Moran E Antagonistic roles for BRM and BRG1 SWI/SNF complexes in differentiation. J Biol Chem. 2009 Jan 14. [Epub ahead of print] PUBMED
Meikle MC Northcroft Memorial Lecture 2007. A century of progress: advances in orthodontics since the foundation of the British Society for the Study of Orthodontics. J Orthod. 2008 Sep;35(3):176-90 PUBMED
Xue Y, Xing Z, Hellem S, Arvidson K, Mustafa K. Endothelial cells influence the osteogenic potential of bone marrow stromal cells. Biomed Eng Online. 2009 Nov 17;8:34. PUBMED
Zheng Z, Cohn MJ. Developmental basis of sexually dimorphic digit ratios. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16289-94 PUBMED
p53 Signaling
Brockschmidt C, Hirner H, Huber N, Eismann T, Hillenbrand A, Giamas G, Radunsky B, Ammerpohl O, Bohm B, Henne-Bruns D, Kalthoff H, Leithauser F, Trauzold A, Knippschild U Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo. Gut. 2008 Jun;57(6):799-806. Epub 2008 Jan 18.  PUBMED
Cutts BA, Sjogren AK, Andersson KM, Wahlstrom AM, Karlsson C, Swolin B, Bergo MO. Nf1 deficiency co-operates with oncogenic K-RAS to induce acute myeloid leukemia Blood. 2009 Aug 26.PUBMED
Barkic M, Crnomarkovic S, Grabusic K, Bogetic I, Panic L, Tamarut S, Cokaric M, Jeric I, Vidak S, Volarevic S. The p53 tumor suppressor causes congenital malformations in Rpl24-deficient mice Mol Cell Biol. 2009 May;29(10):2489-504. Epub 2009 Mar 9.PUBMED
Signal Transduction PathwayFinder
Hager-Theodorides AL, Furmanski AL, Ross SE, Outram SV, Rowbotham NJ, Crompton T. The Gli3 transcription factor expressed in the thymus stroma controls thymocyte J Immunol. 2009 Sep 1;183(5):3023-32. Epub 2009 Aug 10.PUBMED
Bojanic DD, Tarr PT, Gale GD, Smith DJ, Bok D, Chen B, Nusinowitz S, Lovgren-Sandblom A, Bjorkhem I, Edwards PA. Differential expression and function of ABCG1 and ABCG4 during development and J Lipid Res. 2009 Jul 26.PUBMED
Rowbotham NJ, Hager-Theodorides AL, Furmanski AL, Ross SE, Outram SV, Dessens JT, Crompton T. Sonic hedgehog negatively regulates pre-TCR-induced differentiation by a Blood. 2009 May 21;113(21):5144-56. Epub 2009 Mar 9.PUBMED
Hager-Theodorides AL, Furmanski AL, Ross SE, Outram SV, Rowbotham NJ, Crompton T The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms. J Immunol. 2009 Sep 1;183(5):3023-32. Epub 2009 Aug 10.PUBMED
Stem Cell
Xu XL, Xing BC, Han HB, Zhao W, Hu MH, Xu ZL, Li JY, Xie Y, Gu J, Wang Y, Zhang ZQ. The properties of tumor-initiating cells from a hepatocellular carcinoma patient's primary and recurrent tumor. Carcinogenesis. 2010 Feb;31(2):167-74. Epub 2009 Nov 6.PUBMED
Stress & Toxicity PathwayFinder
Johnston N, Wells CW, Samuels TL, Blumin JH. Pepsin in nonacidic refluxate can damage hypopharyngeal epithelial cells. Ann Otol Rhinol Laryngol. 2009 Sep;118(9):677-85PUBMED
T Cell Anergy & Immune Tolerance
Gorczynski RM, Chen Z, He W, Khatri I, Sun Y, Yu K, Boudakov I. Expression of a CD200 transgene is necessary for induction but not maintenance of J Immunol. 2009 Aug 1;183(3):1560-8. Epub 2009 Jul 10.PUBMED
TGFβ BMP Signaling
Garamszegi N, Garamszegi SP, Shehadeh LA, Scully SP. Extracellular matrix-induced gene expression in human breast cancer cells. Mol Cancer Res. 2009 Mar;7(3):319-29. Epub 2009 Mar 10.PUBMED
Th1, Th2, Th3
Torcia MG, Santarlasci V, Cosmi L, Clemente A, Maggi L, Mangano VD, Verra F, Bancone G, Nebie I, Sirima BS, Liotta F, Frosali F, Angeli R, Severini C, Sannella AR, Bonini P, Lucibello M, Maggi E, Garaci E, Coluzzi M, Cozzolino F, Annunziato F, Romagnani S, Modiano D. Functional deficit of T regulatory cells in Fulani, an ethnic group with low susceptibility to Plasmodium falciparum malaria. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):646-51. Epub 2008 Jan 3  PUBMED
Jacob N, Yang H, Pricop L, Liu Y, Gao X, Zheng SG, Wang J, Gao HX, Putterman C, Koss MN, Stohl W, Jacob CO. Accelerated pathological and clinical nephritis in systemic lupus erythematosus-prone New Zealand Mixed 2328 mice doubly deficient in TNF receptor 1 and TNF receptor 2 via a Th17-associated pathway. J Immunol. 2009 Feb 15;182(4):2532-41 PUBMED
Roman J, Rangasamy T, Guo J, Sugunan S, Meednu N, Packirisamy G, Shimoda L, Golding A, Semenza G, Georas SN. T Cell Activation Under Hypoxic Conditions Enhances Interferon-gamma Secretion. Am J Respir Cell Mol Biol. 2009 Apr 16.PUBMED
TH17 for Autoimmunity & Inflammation
Lochner M, Peduto L, Cherrier M, Sawa S, Langa F, Varona R, Riethmacher D, Si-Tahar M, Di Santo JP, Eberl G. In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J Exp Med. 2008 Jun 9;205(6):1381-93. Epub 2008 May 26  PUBMED
Jacob N, Yang H, Pricop L, Liu Y, Gao X, Zheng SG, Wang J, Gao HX, Putterman C, Koss MN, Stohl W, Jacob CO. Accelerated pathological and clinical nephritis in systemic lupus erythematosus-prone New Zealand Mixed 2328 mice doubly deficient in TNF receptor 1 and TNF receptor 2 via a Th17-associated pathway. J Immunol. 2009 Feb 15;182(4):2532-41 PUBMED
Toll-Like Receptor Signaling
Brant KA, Fabisiak JP. Nickel Alterations of TLR2-Dependent Chemokine Profiles in Lung Fibroblasts are Mediated by COX-2. Am J Respir Cell Mol Biol. 2007 Dec 20 [Epub ahead of print]  PUBMED
Ornatowska M, Azim AC, Wang X, Christman JW, Xiao L, Joo M, Sadikot RT. Functional genomics of silencing TREM-1 on TLR4 signaling in macrophages. Am J Physiol Lung Cell Mol Physiol. 2007 Dec;293(6):L1377-84. Epub 2007 Sep 28  PUBMED
Tilton JC, Manion MM, Luskin MR, Johnson AJ, Patamawenu AA, Hallahan CW, Cogliano-Shutta NA, Mican JM, Davey RT Jr, Kottilil S, Lifson JD, Metcalf JA, Lempicki RA, Connors M. Human immunodeficiency virus viremia induces plasmacytoid dendritic cell activation in vivo and diminished alpha interferon production in vitro. J Virol. 2008 Apr;82(8):3997-4006. Epub 2008 Feb 6  PUBMED
Tomchuck SL, Zwezdaryk KJ, Coffelt SB, Waterman RS, Danka ES, Scandurro AB Toll-Like Receptors on Human Mesenchymal Stem Cells Drive their Migration and Immunomodulating Responses. Stem Cells. 2007 Oct 4; [Epub ahead of print] PUBMED
West J, Damania B Upregulation of the TLR3 pathway by Kaposi's sarcoma-associated herpesvirus during primary infection. J Virol. 2008 Jun;82(11):5440-9. Epub 2008 Mar 26  PUBMED
Pr阬e CM, Woodward EA, Bisley J, Keith-Magee A, Nicholson SE, Hart PH. SOCS1 regulates the IFN but not NFkappaB pathway in TLR-stimulated human monocytes and macrophages. J Immunol. 2008 Dec 1;181(11):8018-26. PUBMED
Shin H, Zhang Y, Jagannathan M, Hasturk H, Kantarci A, Liu H, Van Dyke TE, Ganley-Leal LM, Nikolajczyk BS. B cells from periodontal disease patients express surface Toll-like receptor 4 J Leukoc Biol. 2008 Dec 31. [Epub ahead of print] PUBMED
Samuvel DJ, Sundararaj KP, Nareika A, Lopes-Virella MF, Huang Y. Lactate boosts TLR4 signaling and NF-kappaB pathway-mediated gene transcription in macrophages via monocarboxylate transporters and MD-2 up-regulation. J Immunol. 2009 Feb 15;182(4):2476-84 PUBMED
Chen GY, Shiah HC, Su HJ, Chen CY, Chuang YJ, Lo WH, Huang JL, Chuang CK, Hwang SM, Hu YC. Baculovirus transduction of mesenchymal stem cells triggers the toll-like J Virol. 2009 Oct;83(20):10548-56. Epub 2009 Aug 5.PUBMED
Zhang X, Alnaeeli M, Singh B, Teng YT. Involvement of SOCS3 in regulation of CD11c+ dendritic cell-derived Infect Immun. 2009 May;77(5):2000-9. Epub 2009 Mar 2.PUBMED
Soulika AM, Lee E, McCauley E, Miers L, Bannerman P, Pleasure D Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis. J Neurosci. 2009 Nov 25;29(47):14965-79.PUBMED
Transcription Factors
Yuvaraj S, Griffin AC, Sundaram K, Kirkwood KL, Norris JS, Reddy SV. A novel function of CXCL13 to stimulate RANK ligand expression in oral squamous Mol Cancer Res. 2009 Aug;7(8):1399-407. Epub 2009 Aug 11.PUBMED
Middeldorp J, Kamphuis W, Sluijs JA, Achoui D, Leenaars CH, Feenstra MG, van Tijn P, Fischer DF, Berkers C, Ovaa H, Quinlan RA, Hol EM. Intermediate filament transcription in astrocytes is repressed by proteasome FASEB J. 2009 Aug;23(8):2710-26. Epub 2009 Mar 30.PUBMED
Toxicology
Joseph, P. et al. Heme-oxygenase 1 Gene Expression is a Marker for Hexavalent Chromium-Induced Stress and Toxicity in Human Dermal Fibroblasts. Toxicol. Sci., Jun 2008; 103: 325 - 334. PUBMED
Marshall, N.B, et al. Functional Characterization and Gene Expression Analysis of CD4+CD25+ Regulatory T Cells Generated in Mice Treated with 2,3,7,8-Tetrachlorodibenzo-p-Dioxin. J. Immunol., Aug 2008; 181: 2382 - 2391. PUBMED
Ning, B. et al. Systematic and Simultaneous Gene Profiling of 84 Drug-Metabolizing Genes in Primary Human Hepatocytes. J Biomol Screen, Mar 2008; 13: 194 - 201. PUBMED
Tumor Metastasis
Wang J, Shiozawa Y, Wang J, Wang Y, Jung Y, Pienta KJ, Mehra R, Lober R, Taichman RS The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/ SDF-1 in prostate cancer. J Biol Chem. 2007 Dec 5 [Epub ahead of print]  PUBMED
WNT Signaling
Aslanidi G, Kroutov V, Philipsberg G, Lamb K, Campbell-Thompson M, Walter GA, Kurenov S, Ignacio Aguirre J, Keller P, Hankenson K, Macdougald OA, Zolotukhin S. Ectopic expression of Wnt10b decreases adiposity and improves glucose homeostasis in obese rats. Am J Physiol Endocrinol Metab. 2007 Sep;293(3):E726-36. Epub 2007 Jun 19 PUBMED
Giuliani N, Morandi F, Tagliaferri S, Lazzaretti M, Donofrio G, Bonomini S, Sala R, Mangoni M, Rizzoli V. Production of wnt inhibitors by myeloma cells: potential effects on canonical wnt pathway in the bone microenvironment. Cancer Res. 2007 Aug 15;67(16):7665-74. PUBMED
Guo W, Flanagan J, Jasuja R, Kirkland J, Jiang L, Bhasin S. The Effects of Myostatin on Adipogenic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells Are Mediated through Cross-communication between Smad3 and Wnt/{beta}-Catenin Signaling Pathways. J Biol Chem. 2008 Apr 4;283(14):9136-45. Epub 2008 Jan 18. PUBMED
Hidestrand M, Richards-Malcolm S, Gurley CM, Nolen G, Grimes B, Waterstrat A, Zant GV, Peterson CA. Sca-1-expressing nonmyogenic cells contribute to fibrosis in aged skeletal muscle. J Gerontol A Biol Sci Med Sci. 2008 Jun;63(6):566-79. PUBMED
Welters HJ, Oknianska A, Erdmann KS, Ryffel GU, Morgan NG The protein tyrosine phosphatase-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signaling pathway. J Endocrinol. 2008 Jun;197(3):543-52. Epub 2008 Apr 15 PUBMED
Malhotra S, Baba Y, Garrett KP, Staal FJ, Gerstein R, Kincade PW. Contrasting responses of lymphoid progenitors to canonical and noncanonical Wnt signals. J Immunol. 2008 Sep 15;181(6):3955-64. PUBMED
Gelebart P, Anand M, Armanious H, Peters AC, Dien Bard J, Amin HM, Lai R. Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma. Blood. 2008 Dec 15;112(13):5171-9. Epub 2008 Sep 11. PUBMED
Jonassen JA, San Agustin J, Follit JA, Pazour GJ. Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol. 2008 Nov 3;183(3):377-84. PUBMED
Wu QL, Zierold C, Ranheim EA Dysregulation of frizzled 6 is a critical component of B cell leukemogenesis in a mouse model of chronic lymphocytic leukemia. Blood. 2009 Jan 28. [Epub ahead of print] PUBMED
Ghosh MC, Collins GD, Vandanmagsar B, Patel K, Brill M, Carter A, Lustig A, Becker KG, Wood WW 3rd, Emeche CD, French AD, O'Connell MP, Xu M, Weeraratna AT, Taub DD. Activation of Wnt5A signaling is required for CXC chemokine ligand 12-mediated Blood. 2009 Aug 13;114(7):1366-73. Epub 2009 Jun 11.PUBMED
Hussain M, Rao M, Humphries AE, Hong JA, Liu F, Yang M, Caragacianu D, Schrump DS. Tobacco smoke induces polycomb-mediated repression of Dickkopf-1 in lung cancer Cancer Res. 2009 Apr 15;69(8):3570-8. Epub 2009 Apr 7.PUBMED
Naik S, Dothager RS, Marasa J, Lewis CL, Piwnica-Worms D. Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant {beta}-Catenin Activation in Colon Cancer. Clin Cancer Res. 2009 Dec 15;15(24):7529-7537.PUBMED

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SureSilencing siRNA

 
Control siRNA sequence
Li X, Barkho BZ, Luo Y, Smrt RD, Santistevan NJ, Liu C, Kuwabara T, Gage FH, Zhao X. Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural J Biol Chem. 2008 Oct 10;283(41):27644-52. Epub 2008 Aug 8.PUBMED

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SureSilencing shRNA Plasmids

Cancer
Baritaki S, Huerta-Yepez S, Sakai T, Spandidos DA, Bonavida B. Chemotherapeutic drugs sensitize cancer cells to TRAIL-mediated apoptosis: up-regulation of DR5 and inhibition of Yin Yang 1. Mol Cancer Ther. 2007 Apr;6(4):1387-99. PUBMED
Demorrow S, Francis H, Gaudio E, Ueno Y, Venter J, Onori P, Franchitto A, Vaculin B, Vaculin S, Alpini G Anandamide inhibits cholangiocyte hyperplastic proliferation via activation of thioredoxin 1/redox factor 1 and AP-1 activation. Am J Physiol Gastrointest Liver Physiol. 2007 Dec 20 [Epub ahead of print]  PUBMED
Demorrow S, Glaser S, Francis H, Venter J, Vaculin B, Vaculin S, Alpini G. Opposing actions of endocannabinoids on cholangiocarcinoma growth: Recruitment of fas and fas ligand to lipid rafts. J Biol Chem. 2007 Apr 27;282(17):13098-113. Epub 2007 Feb 28. PUBMED
Dhakshinamoorthy S, Sridharan SR, Li L, Ng PY, Boxer LM, Porter AG Protein/DNA arrays identify nitric oxide-regulated cis-element and trans-factor activities some of which govern neuroblastoma cell viability. Nucleic Acids Res. 2007;35(16):5439-51. Epub 2007 Aug 15. PUBMED
Dimple C, Nair SS, Rajhans R, Pitcheswara PR, Liu J, Balasenthil S, Le XF, Burow ME, Auersperg N, Tekmal RR, Broaddus RR, Vadlamudi RK. Role of PELP1/MNAR signaling in ovarian tumorigenesis. Cancer Res. 2008 Jun 15;68(12):4902-9.  PUBMED
Guo Y, Xie J, Rubin E, Tang YX, Lin F, Zi X, Hoang BH. Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling. Cancer Res. 2008 May 1;68(9):3350-60  PUBMED
Horak CE, Lee JH, Elkahloun AG, Boissan M, Dumont S, Maga TK, Arnaud-Dabernat S, Palmieri D, Stetler-Stevenson WG, Lacombe ML, Meltzer PS, Steeg PS. Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2. Cancer Res. 2007 Aug 1;67(15):7238-46. PUBMED
McFate T, Mohyeldin A, Lu H, Thakar J, Henriques J, Halim ND, Wu H, Schell MJ, Tsang TM, Teahan O, Zhou S, Califano JA, Jeoung NH, Harris RA, Verma A. Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells. J Biol Chem. 2008 Jun 9. [Epub ahead of print]  PUBMED
McGowan PM, Ryan BM, Hill AD, McDermott E, O'Higgins N, Duffy MJ. ADAM-17 expression in breast cancer correlates with variables of tumor progression. Clin Cancer Res. 2007 Apr 15;13(8):2335-43 PUBMED
Rajhans R, Nair HB, Nair SS, Cortez V, Ikuko K, Kirma NB, Zhou D, Holden AE, Brann DW, Chen S, Tekmal RR, Vadlamudi RK. Modulation of in situ Estrogen Synthesis by PELP1: Potential ER Autocrine Signaling Loop in Breast Cancer Cells Mol Endocrinol. 2007 Dec 13 [Epub ahead of print]  PUBMED
Tirado OM, Mateo-Lozano S, Villar J, Dettin LE, Llort A, Gallego S, Ban J, Kovar H, Notario V. Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells. Cancer Res. 2006 Oct 15;66(20):9937-47. PUBMED
Zhao S, Venkatasubbarao K, Lazor JW, Sperry J, Jin C, Cao L, Freeman JW Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells. Cancer Res. 2008 Jun 1;68(11):4221-8  PUBMED
Saifudeen Z, Dipp S, Stefkova J, Yao X, Lookabaugh S, El-Dahr SS. p53 regulates metanephric development. J Am Soc Nephrol. 2009 Nov;20(11):2328-37. Epub 2009 Sep 3. PUBMED
Ju CH, Chockalingam A, Leifer CA. Early response of mucosal epithelial cells during Toxoplasma gondii infection. J Immunol. 2009 Dec 1;183(11):7420-7. Epub 2009 Nov 16. PUBMED
Richter K, Brar S, Ray M, Pisitkun P, Bolland S, Verkoczy L, Diaz M. Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells. J Biol Chem. 2009 Oct 30;284(44):30652-61. Epub 2009 Sep 4. PUBMED
Li FQ, Mofunanya A, Fischer V, Hall J, Takemaru K. Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling. Mol Biol Cell. 2010 Jan;21(2):311-22. Epub 2009 Nov 25. PUBMED
Ciccone NA, Xu S, Lacza CT, Carroll RS, Kaiser UB. Frequency-dependent regulation of follicle-stimulating hormone beta by pulsatile gonadotropin-releasing hormone is mediated by functional antagonism of bZIP transcription factors. Mol Cell Biol. 2010 Feb;30(4):1028-40. Epub 2009 Dec 14. PUBMED
Ungvari Z, Labinskyy N, Mukhopadhyay P, Pinto JT, Bagi Z, Ballabh P, Zhang C, Pacher P, Csiszar A. Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells. Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1876-81. Epub 2009 Sep 11. PUBMED
Cardiovascular Disease
Torella D, Curcio A, Gasparri C, Galuppo V, De Serio D, Surace FC, Cavaliere AL, Leone A, Coppola C, Ellison GM, Indolfi C. Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2935-43. Epub 2007 Feb 9. PUBMED
Immunology
Lawson BR, Manenkova Y, Ahamed J, Chen X, Zou JP, Baccala R, Theofilopoulos AN, Yuan C. Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system. J Immunol. 2007 Apr 15;178(8):5366-74. PUBMED
Wang J, Barke RA, Charboneau R, Schwendener R, Roy S. Morphine Induces Defects in Early Response of Alveolar Macrophages to Streptococcus pneumoniae by Modulating TLR9-NF-{kappa}B Signaling. J Immunol. 2008 Mar 1;180(5):3594-600.  PUBMED
Neuroscience
Uo T, Kinoshita Y, Morrison RS. Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons J Neurosci. 2007 Nov 7;27(45):12198-210. PUBMED
Signal Transduction
Ciccone NA, Lacza CT, Hou MY, Gregory SJ, Kam KY, Xu S, Kaiser UB. A Composite Element that Binds Basic Helix Loop Helix and Basic Leucine Zipper Transcription Factors Is Important for GnRH Regulation of the FSH{beta} Gene. Mol Endocrinol. 2008 Jun 11. [Epub ahead of print]  PUBMED
Xue M, Campbell D, Jackson CJ Protein C is an autocrine growth factor for human skin keratinocytes J Biol Chem. 2007 May 4;282(18):13610-6. Epub 2007 Feb 9. PUBMED
Stem Cells
Guo Y, Mantel C, Hromas RA, Broxmeyer HE Oct-4 is critical for survival/antiapoptosis of murine embryonic stem cells subjected to stress: effects associated with Stat3/survivin. Stem Cells. 2008 Jan;26(1):30-4. Epub 2007 Oct 11  PUBMED
Liou JY, Ellent DP, Lee S, Goldsby J, Ko BS, Matijevic N, Huang JC, Wu KK. Cyclooxygenase-2-derived prostaglandin e2 protects mouse embryonic stem cells from apoptosis. Stem Cells. 2007 May;25(5):1096-103. Epub 2007 Jan 18. PUBMED
Wang XY, Yin Y, Yuan H, Sakamaki T, Okano H, Glazer RI. Musashi1 modulates mammary progenitor cell expansion through proliferin-mediated activation of the Wnt and Notch pathways. Mol Cell Biol. 2008 Jun;28(11):3589-99. Epub 2008 Mar 24  PUBMED
Akt1
Harada H, Itasaka S, Kizaka-Kondoh S, Shibuya K, Morinibu A, Shinomiya K, Hiraoka M. Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors. J Biol Chem. 2008 Dec 19. [Epub ahead of print] PUBMED
alpha-TM
Lange K, Kammerer M, Saupe F, Hegi ME, Grotegut S, Fluri E, Orend G. Combined lysophosphatidic acid/platelet-derived growth factor signaling triggers glioma cell migration in a tenascin-C microenvironment. Cancer Res. 2008 Sep 1;68(17):6942-52. PUBMED
BRCAI
Deng C, Ueda E, Chen KE, Bula C, Norman AW, Luben RA, Walker AM Prolactin blocks nuclear translocation of VDR by regulating its interaction with BRCA1 in osteosarcoma cells Mol Endocrinol. 2009 Feb;23(2):226-36. Epub 2008 Dec 12 PUBMED
HePTP
McAlees JW, Sanders VM Hematopoietic protein tyrosine phosphatase mediates beta2-adrenergic receptor-induced regulation of p38 mitogen-activated protein kinase in B lymphocytes. Mol Cell Biol. 2009 Feb;29(3):675-86. Epub 2008 Dec 1 PUBMED
HRB
Chaineau M, Danglot L, Proux-Gillardeaux V, Galli T Role of HRB in clathrin-dependent endocytosis J Biol Chem. 2008 Dec 5;283(49):34365-73. Epub 2008 Sep 25 PUBMED
MBD2
Ramachandran K, Gopisetty G, Gordian E, Navarro L, Hader C, Reis IM, Schulz WA, Singal R. Methylation-Mediated Repression of GADD45{alpha} in Prostate Cancer and Its Role as a Potential Therapeutic Target. Cancer Res. 2009 Feb 3. [Epub ahead of print] PUBMED
MGMT
Zheng M, Bocangel D, Ramesh R, Ekmekcioglu S, Poindexter N, Grimm EA, Chada S Interleukin-24 overcomes temozolomide resistance and enhances cell death by down-regulation of O6-methylguanine-DNA methyltransferase in human melanoma cells. Mol Cancer Ther. 2008 Dec;7(12):3842-51. Epub 2008 Dec 3 PUBMED
MMP-3, MMP-9
Barkho BZ, Munoz AE, Li X, Li L, Cunningham LA, Zhao X Endogenous matrix metalloproteinase (MMP)-3 and MMP-9 promote the differentiation and migration of adult neural progenitor cells in response to chemokines. Stem Cells. 2008 Dec;26(12):3139-49. Epub 2008 Sep 25 PUBMED
Dnmt3a
Do JT, Han DW, Gentile L, Sobek-Klocke I, Stehling M, Sch鰈er HR. Enhanced Reprogramming of Xist by induced upregulation of Tsix and Dnmt3a. Stem Cells. 2008 Aug 28. [Epub ahead of print] PUBMED
OSX
Mikami Y, Somei M, Takagi M. A New Synthetic Compound, SST-VEDI-1, Inhibits Osteoblast Differentiation with a Down-Regulation of the Osterix Expression. J Biochem. 2009 Feb;145(2):239-247. Epub 2008 Dec 8. PUBMED
RALT
Cai J, Yi FF, Yang L, Shen DF, Yang Q, Li A, Ghosh AK, Bian ZY, Yan L, Tang QZ, Li H, Yang XC. Targeted Expression of Receptor-Associated Late Transducer Inhibits Maladaptive Hypertrophy via Blocking Epidermal Growth Factor Receptor Signaling. Hypertension. 2009 Feb 9. [Epub ahead of print] PUBMED
ROR2,  Wnt5a
DeMorrow S, Francis H, Gaudio E, Venter J, Franchitto A, Kopriva S, Onori P, Mancinelli R, Frampton G, Coufal M, Mitchell B, Vaculin B, Alpini G. The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway. Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295(6):G1150-8. Epub 2008 Oct 2 PUBMED
TCF4
Tang Y, Simoneau AR, Liao WX, Yi G, Hope C, Liu F, Li S, Xie J, Holcombe RF, Jurnak FA, Mercola D, Hoang BH, Zi X. WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. Mol Cancer Ther. 2009 Feb;8(2):458-68. Epub 2009 Jan 27 PUBMED
TRPV4
Gao F, Sui D, Garavito RM, Worden RM, Wang DH. Salt intake augments hypotensive effects of transient receptor potential vanilloid 4: functional significance and implication. Hypertension. 2009 Feb;53(2):228-35. Epub 2008 Dec 15 PUBMED
Uhrf2
Iwata A, Nagashima Y, Matsumoto L, Suzuki T, Yamanaka T, Date H, Deoka K, Nukina N, Tsuji S. Intra-nuclear degradation of polyglutamine aggregates by the ubiquitin proteasome system. J Biol Chem. 2009 Feb 13. [Epub ahead of print] PUBMED
ZW10
Whyte J, Bader JR, Tauhata SB, Raycroft M, Hornick J, Pfister KK, Lane WS, Chan GK, Hinchcliffe EH, Vaughan PS, Vaughan KT Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis. J Cell Biol. 2008 Dec 1;183(5):819-34. Epub 2008 Nov 24 PUBMED
BIRC5
Pise-Masison CA, Radonovich M, Dohoney K, Morris JC, O'Mahony D, Lee MJ, Trepel J, Waldmann TA, Janik JE, Brady JN. Gene expression profiling of ATL patients: compilation of disease related genes and evidence for TCF-4 involvement in BIRC5 gene expression and cell viability. Blood. 2009 Jan 8. [Epub ahead of print] PUBMED
Ppapdc3/NET39
Liu GH, Guan T, Datta K, Coppinger J, Yates J 3rd, Gerace L. Regulation of myoblast differentiation by the nuclear envelope protein NET39. Mol Cell Biol. 2009 Nov;29(21):5800-12. Epub 2009 Aug 24.PUBMED
KLF5
Mori A, Moser C, Lang SA, Hackl C, Gottfried E, Kreutz M, Schlitt HJ, Geissler EK, Stoeltzing O. Up-regulation of Kruppel-like factor 5 in pancreatic cancer is promoted by Mol Cancer Res. 2009 Aug;7(8):1390-8. Epub 2009 Aug 11.PUBMED
CaMKII
Sebeo J, Hsiao K, Bozdagi O, Dumitriu D, Ge Y, Zhou Q, Benson DL. Requirement for protein synthesis at developing synapses. J Neurosci. 2009 Aug 5;29(31):9778-93.PUBMED
PP5
Zhang Y, Leung DY, Nordeen SK, Goleva E. Estrogen inhibits glucocorticoid action via protein phosphatase 5 (PP5)-mediated J Biol Chem. 2009 Sep 4;284(36):24542-52. Epub 2009 Jul 8.PUBMED
P2X7
Nobbio L, Sturla L, Fiorese F, Usai C, Basile G, Moreschi I, Benvenuto F, Zocchi E, De Flora A, Schenone A, Bruzzone S. P2X7-mediated increased intracellular calcium causes functional derangement in J Biol Chem. 2009 Aug 21;284(34):23146-58. Epub 2009 Jun 22.PUBMED
PGC-1, PGC-1, and GCN5
Wareski P, Vaarmann A, Choubey V, Safiulina D, Liiv J, Kuum M, Kaasik A. PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons. J Biol Chem. 2009 Aug 7;284(32):21379-85. Epub 2009 Jun 19.PUBMED
XIAP, PTEN
Van Themsche C, Leblanc V, Parent S, Asselin E. X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, J Biol Chem. 2009 Jul 31;284(31):20462-6. Epub 2009 May 27.PUBMED
Ets-1
Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, Horiuchi D, Lebbink RJ, Mo YY, Goga A, McManus MT. Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. J Biol Chem. 2009 Jul 3;284(27):18515-24. Epub 2009 May 6.PUBMED
15-LOX
Calandria JM, Marcheselli VL, Mukherjee PK, Uddin J, Winkler JW, Petasis NA, Bazan NG. Selective survival rescue in 15-lipoxygenase-1-deficient retinal pigment J Biol Chem. 2009 Jun 26;284(26):17877-82. Epub 2009 Apr 29.PUBMED
Annexin A6
Monastyrskaya K, Babiychuk EB, Hostettler A, Wood P, Grewal T, Draeger A. Plasma membrane-associated annexin A6 reduces Ca2+ entry by stabilizing the J Biol Chem. 2009 Jun 19;284(25):17227-42. Epub 2009 Apr 22.PUBMED
ALK1, ALK5
Blaney Davidson EN, Remst DF, Vitters EL, van Beuningen HM, Blom AB, Goumans MJ, van den Berg WB, van der Kraan PM. Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in J Immunol. 2009 Jun 15;182(12):7937-45.PUBMED
ERRa
Chisamore MJ, Wilkinson HA, Flores O, Chen JD. Estrogen-related receptor-alpha antagonist inhibits both estrogen Mol Cancer Ther. 2009 Mar;8(3):672-81. Epub 2009 Mar 10.PUBMED
CypD
Eliseev RA, Malecki J, Lester T, Zhang Y, Humphrey J, Gunter TE. Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect. J Biol Chem. 2009 Apr 10;284(15):9692-9. Epub 2009 Feb 19.PUBMED
E2F7
Endo-Munoz L, Dahler A, Teakle N, Rickwood D, Hazar-Rethinam M, Abdul-Jabbar I, Sommerville S, Dickinson I, Kaur P, Paquet-Fifield S, Saunders N. E2F7 can regulate proliferation, differentiation, and apoptotic responses in Cancer Res. 2009 Mar 1;69(5):1800-8. Epub 2009 Feb 17.PUBMED
Megf8
Zhang Z, Alpert D, Francis R, Chatterjee B, Yu Q, Tansey T, Sabol SL, Cui C, Bai Y, Koriabine M, Yoshinaga Y, Cheng JF, Chen F, Martin J, Schackwitz W, Gunn TM, Kramer KL, De Jong PJ, Pennacchio LA, Lo CW. Massively parallel sequencing identifies the gene Megf8 with ENU-induced mutation Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3219-24. Epub 2009 Feb 13.PUBMED
Uhrf2
Iwata A, Nagashima Y, Matsumoto L, Suzuki T, Yamanaka T, Date H, Deoka K, Nukina N, Tsuji S. Intranuclear degradation of polyglutamine aggregates by the ubiquitin-proteasome J Biol Chem. 2009 Apr 10;284(15):9796-803. Epub 2009 Feb 13.PUBMED
PPARgamma
Ghosh AK, Bhattacharyya S, Wei J, Kim S, Barak Y, Mori Y, Varga J. Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent FASEB J. 2009 Sep;23(9):2968-77. Epub 2009 Apr 24.PUBMED
Rab11a and Rab11b
Silvis MR, Bertrand CA, Ameen N, Golin-Bisello F, Butterworth MB, Frizzell RA, Bradbury NA. Rab11b regulates the apical recycling of the cystic fibrosis transmembrane Mol Biol Cell. 2009 Apr;20(8):2337-50. Epub 2009 Feb 25.PUBMED
Caveolin-1
Liao WX, Feng L, Zhang H, Zheng J, Moore TR, Chen DB. Compartmentalizing VEGF-induced ERK2/1 signaling in placental artery endothelial Mol Endocrinol. 2009 Sep;23(9):1428-44. Epub 2009 May 28.PUBMED

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RT² miRNA PCR Arrays

miR-33
Rayner KJ, Suárez Y, Dávalos A, Parathath S, Fitzgerald ML, Tamehiro N, Fisher EA, Moore KJ, Fernández-Hernando C.
MiR-33 Contributes to the Regulation of Cholesterol Homeostasis Science. 2010 Jun 18;328(5985):1570-3
Detail
miR-382
Alison J. Kriegel, Yi Fang, Yong Liu, Zhongmin Tian, Domagoj Mladinov, Isaac R. Matus, Xiaoqiang Ding, Andrew S. Greene, and Mingyu Liang MicroRNA-target pairs in human renal epithelial cells treated with transforming growth factor β1: a novel role of miR-382 RNA: Nucleic Acids Res., Aug 2010; 10.1093/nar/gkq718.Detail
Biomarker
Philippidou D, Schmitt M, Moser D, Margue C, Nazarov PV, Muller A, Vallar L, Nashan D, Behrmann I, Kreis S. Signatures of microRNAs and selected microRNA target genes in human melanoma. TUMOR AND STEM CELL BIOLOGY: Cancer Res., May 2010; 70: 4163 - 4173.Detail
miR-24
Liao WX, Feng L, Zhang H, Zheng J, Moore TR, Chen DB. Compartmentalizing VEGF-induced ERK2/1 signaling in placental artery endothelial Mol Endocrinol. 2009 Sep;23(9):1428-44. Epub 2009 May 28.
PUBMED
PUBMED
miR-25
Kuhn AR, Schlauch K, Lao R, Halayko AJ, Gerthoffer WT, Singer CA. MicroRNA Expression in Human Airway Smooth Muscle Cells: Role of miR-25 in Regulation of Airway Smooth Muscle Phenotype Am J Respir Cell Mol Biol. 2010 Apr;42(4):506-13.PUBMED

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RT² PCR Primer Sets

Acuff HB, Sinnamon M, Fingleton B, Boone B, Levy SE, Chen X, Pozzi A, Carbone DP, Schwartz DR, Moin K, Sloane BF, Matrisian LM. Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer. Cancer Res. 2006 Aug 15;66(16):7968-75. PUBMED
Albanesi C, Fairchild HR, Madonna S, Scarponi C, De Pit?O, Leung DY, Howell MD. IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3. J Immunol. 2007 Jul 15;179(2):984-92 PUBMED
Alikhani M, Alikhani Z, Graves DT. FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis. J Biol Chem. 2005 Apr 1;280(13):12096-102. Epub 2005 Jan 4. PUBMED
Andarawewa KL, Erickson AC, Chou WS, Costes SV, Gascard P, Mott JD, Bissell MJ, Barcellos-Hoff MH. Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition. Cancer Res. 2007 Sep 15;67(18):8662-70. PUBMED
Angeloni C, Leoncini E, Malaguti M, Angelini S, Hrelia P, Hrelia S. Role of quercetin in modulating rat cardiomyocyte gene expression profile Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1233-43. Epub 2008 Jan 4 PUBMED
Artaza JN, Singh R, Ferrini MG, Braga M, Tsao J, Gonzalez-Cadavid NF Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblasts J Endocrinol. 2008 Feb;196(2):235-49
PUBMED
Asprodites N, Zheng L, Geng D, Velasco-Gonzalez C, Sanchez-Perez L, Davila E. Engagement of Toll-like receptor-2 on cytotoxic T-lymphocytes occurs in vivo and augments antitumor activity. FASEB J. 2008 Jun 27. [Epub ahead of print] PUBMED
Augustus AS, Buchanan J, Addya S, Rengo G, Pestell R, Fortina P, Koch WJ, Bensadoun A, Abel ED, Lisanti MP. Substrate Uptake and Metabolism are Preserved in Hypertrophic Caveolin-3 Knockout Hearts. Am J Physiol Heart Circ Physiol. 2008 Jun 13. [Epub ahead of print] PUBMED
Beinfeld MC, Blum A, Vishnuvardhan D, Fanous S, Marchand JE Cholecystokinin levels in prohormone convertase 2 knock-out mouse brain regions reveal a complex phenotype of region-specific alterations J Biol Chem. 2005 Nov 18;280(46):38410-5. Epub 2005 Sep 20 PUBMED
Beretsos P, Loutradis D, Koussoulakos S, Margaritis LH, Kiapekou E, Mastorakos G, Papaspirou I, Makris N, Makrigiannakis A, Antsaklis A. Oxytocin receptor is differentially expressed in mouse endometrium and embryo during blastocyst implantation. Ann N Y Acad Sci. 2006 Dec;1092:466-79. PUBMED
Binnerts ME, Kim KA, Bright JM, Patel SM, Tran K, Zhou M, Leung JM, Liu Y, Lomas WE 3rd, Dixon M, Hazell SA, Wagle M, Nie WS, Tomasevic N, Williams J, Zhan X, Levy MD, Funk WD, Abo A. R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14700-5. Epub 2007 Sep 5 PUBMED
Bird AD, Tan KH, Olsson PF, Zieba M, Flecknoe SJ, Liddicoat DR, Mollard R, Hooper SB, Cole TJ. Identification of glucocorticoid-regulated genes that control cell proliferation during murine respiratory development. J Physiol. 2007 Nov 15;585(Pt 1):187-201. Epub 2007 Sep 27 PUBMED
Boer B, Kopp J, Mallanna S, Desler M, Chakravarthy H, Wilder PJ, Bernadt C, Rizzino A. Elevating the levels of Sox2 in embryonal carcinoma cells and embryonic stem cells inhibits the expression of Sox2:Oct-3/4 target genes. Nucleic Acids Res. 2007;35(6):1773-86. Epub 2007 Feb 25 PUBMED
Bossard C, Bresson D, Polishchuk RS, Malhotra V. Dimeric PKD regulates membrane fission to form transport carriers at the TGN. J Cell Biol. 2007 Dec 17;179(6):1123-31.  PUBMED
Brandl K, Plitas G, Schnabl B, DeMatteo RP, Pamer EG. MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. J Exp Med. 2007 Aug 6;204(8):1891-900. Epub 2007 Jul 16 PUBMED
Brest P, Gustafsson M, Mossberg AK, Gustafsson L, Duringer C, Hamiche A, Svanborg C. Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET. Cancer Res. 2007 Dec 1;67(23):11327-34  PUBMED
Brown JM, Swindle EJ, Kushnir-Sukhov NM, Holian A, Metcalfe DD. Silica-Directed Mast Cell Activation Is Enhanced by Scavenger Receptors. Am J Respir Cell Mol Biol. 2007 Jan;36(1):43-52. Epub 2006 Aug 10 PUBMED
Burgess SJ, Marusina AI, Pathmanathan I, Borrego F, Coligan JE IL-21 Down-Regulates NKG2D/DAP10 Expression on Human NK and CD8+ T Cells J Immunol. 2006 Feb 1;176(3):1490-7 PUBMED
Chen S, Sims GP, Chen XX, Gu YY, Chen S, Lipsky PE. Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol. 2007 Aug 1;179(3):1634-47 PUBMED
Cheng W, Jacobs WB, Zhang JJ, Moro A, Park JH, Kushida M, Qiu W, Mills AA, Kim PC. DeltaNp63 plays an anti-apoptotic role in ventral bladder development. Development. 2006 Dec;133(23):4783-92. Epub 2006 Nov 1. PUBMED
Chiao E, Elazar M, Xing Y, Xiong A, Kmet M, Millan MT, Glenn JS, Wong WH, Baker J. Isolation and Transcriptional Profiling of Purified Hepatic Cells Derived from Human Embryonic Stem Cells. Stem Cells. 2008 Jun 5. [Epub ahead of print]  PUBMED
Crossno JT Jr, Majka SM, Grazia T, Gill RG, Klemm DJ. Rosiglitazone promotes development of a novel adipocyte population from bone marrow-derived circulating progenitor cells. J Clin Invest. 2006 Dec;116(12):3220-8 PUBMED
Dai J, Hall CL, Escara-Wilke J, Mizokami A, Keller JM, Keller ET. Prostate cancer induces bone metastasis through Wnt-induced bone morphogenetic protein-dependent and independent mechanisms. Cancer Res. 2008 Jul 15;68(14):5785-94.  PUBMED
Datta A, Sinha-Datta U, Dhillon NK, Buch S, Nicot C. The HTLV-I p30 Interferes with TLR4 Signaling and Modulates the Release of Pro- and Anti-inflammatory Cytokines from Human Macrophages. J Biol Chem. 2006 Aug 18;281(33):23414-24. Epub 2006 Jun 19. PUBMED
Demorrow S, Francis H, Gaudio E, Ueno Y, Venter J, Onori P, Franchitto A, Vaculin B, Vaculin S, Alpini G Anandamide inhibits cholangiocyte hyperplastic proliferation via activation of thioredoxin 1/redox factor 1 and AP-1 activation. Am J Physiol Gastrointest Liver Physiol. 2007 Dec 20 [Epub ahead of print]  PUBMED
DeMorrow S, Glaser S, Francis H, Venter J, Vaculin B, Vaculin S, Alpini G Opposing actions of endocannabinoids on cholangiocarcinoma growth: recruitment of Fas and Fas ligand to lipid rafts. J Biol Chem. 2007 Apr 27;282(17):13098-113. Epub 2007 Feb 28 PUBMED
Dhillon NK, Peng F, Ransohoff RM, Buch S PDGF synergistically enhances IFN-gamma-induced expression of CXCL10 in blood-derived macrophages: implications for HIV dementia. J Immunol. 2007 Sep 1;179(5):2722-30 PUBMED
Dimitrijevic OB, Stamatovic SM, Keep RF, Andjelkovic AV Absence of the chemokine receptor CCR2 protects against cerebral ischemia/reperfusion injury in mice. Stroke. 2007 Apr;38(4):1345-53. Epub 2007 Mar 1 PUBMED
Dominguez J, Wu P, Packer CS, Temm C, Kelly KJ. Lipotoxic and inflammatory phenotypes in rats with uncontrolled metabolic syndrome and nephropathy. Am J Physiol Renal Physiol. 2007 Sep;293(3):F670-9. Epub 2007 Jun 27 PUBMED
Drew JE, Farquharson AJ, Padidar S, Duthie GG, Mercer JG, Arthur JR, Morrice PC, Barrera LN. Insulin, leptin, and adiponectin receptors in colon: regulation relative to differing body adiposity independent of diet and in response to dimethylhydrazine. Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G682-91. Epub 2007 Jul 26 PUBMED
Emmons J, Townley-Tilson WH, Deleault KM, Skinner SJ, Gross RH, Whitfield ML, Brooks SA Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation. RNA. 2008 May;14(5):888-902. Epub 2008 Mar 26.  PUBMED
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Bogacheva O, Bogachev O, Menon M, Dev A, Houde E, Valoret EI, Prosser HM, Creasy CL, Pickering SJ, Grau E, Rance K, Livi GP, Karur V, Erickson-Miller CL, Wojchowski DM. DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia. J Biol Chem. 2008 Dec 26;283(52):36665-75. Epub 2008 Oct 14. PUBMED
Shi Y, Yadav VK, Suda N, Liu XS, Guo XE, Myers MG Jr, Karsenty G Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20529-33. Epub 2008 Dec 11 PUBMED
Sol醨 P, Koval J, Mikes J, Kleban J, Sol醨ov?Z, Laz鷕 J, Hodorov?I, Fedorocko P, Sytkowski AJ. Erythropoietin inhibits apoptosis induced by photodynamic therapy in ovarian cancer cells. Mol Cancer Ther. 2008 Aug;7(8):2263-71. Epub 2008 Aug 6. PUBMED
Ajmo JM, Liang X, Rogers CQ, Pennock B, You M. Resveratrol alleviates alcoholic fatty liver in mice. Am J Physiol Gastrointest Liver Physiol. 2008 Oct;295(4):G833-42. Epub 2008 Aug 28. PUBMED
Chang W, Tu C, Chen TH, Bikle D, Shoback D. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Sci Signal. 2008;1(35):pe40. PUBMED
Martinez HD, Jasavala RJ, Hinkson I, Fitzgerald L, Trimmer JS, Kung HJ, Wright ME. RNA editing of androgen receptor gene-transcripts in prostate cancer cells. J Biol Chem. 2008 Aug 20. [Epub ahead of print] PUBMED
Szasz T, Thompson JM, Watts SW. A comparison of reactive oxygen species metabolism in the rat aorta and vena cava: focus on xanthine oxidase. Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H1341-H1350. Epub 2008 Jul 25. PUBMED
Anderson LJ, Longnecker R. Epstein-Barr virus latent membrane protein 2A exploits Notch1 to alter B-cell identity in vivo. Blood. 2009 Jan 1;113(1):108-16. Epub 2008 Sep 24. PUBMED
Bradley RL, Jeon JY, Liu FF, Maratos-Flier E. Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice. Am J Physiol Endocrinol Metab. 2008 Sep;295(3):E586-94. Epub 2008 Jun 24. PUBMED
Singh R, Bhasin S, Braga M, Artaza JN, Pervin S, Taylor WE, Krishnan V, Sinha SK, Rajavashisth TB, Jasuja R. Regulation of Myogenic Differentiation by Androgens: Cross-Talk between Androgen Receptor/{beta}-Catenin and Follistatin/TGF-{beta} Signaling Pathways. Endocrinology. 2008 Oct 23. [Epub ahead of print] PUBMED
McLaughlin-Drubin ME, Huh KW, M黱ger K Human papillomavirus type 16 E7 oncoprotein associates with E2F6. J Virol. 2008 Sep;82(17):8695-705. PUBMED
Stice JP, Eiserich JP, Knowlton AA. Role of aging versus the loss of estrogens in the reduction in vascular function in female rats. Endocrinology. 2009 Jan;150(1):212-9. Epub 2008 Sep 11 PUBMED
Dakhova O, O'Day D, Kinet N, Yucer N, Wiese M, Shetty G, Ducy P. Dickkopf-like1 regulates postpubertal spermatocyte apoptosis and testosterone production. Endocrinology. 2009 Jan;150(1):404-12. Epub 2008 Sep 25 PUBMED
Jain S, Vinukonda G, Fiering SN, Kumar A A haplotype of human angiotensinogen gene containing -217A increases blood pressure in transgenic mice compared with -217G. Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R1849-57. Epub 2008 Oct 22 PUBMED
DeMorrow S, Francis H, Gaudio E, Venter J, Franchitto A, Kopriva S, Onori P, Mancinelli R, Frampton G, Coufal M, Mitchell B, Vaculin B, Alpini G. The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway. Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295(6):G1150-8. Epub 2008 Oct 2 PUBMED
Bian ZM, Elner SG, Elner VM. Regulated expression of caspase-12 gene in human retinal pigment epithelial cells suggests its immunomodulating role. Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5593-601. Epub 2008 Sep 12 PUBMED
Alpini G, Invernizzi P, Gaudio E, Venter J, Kopriva S, Bernuzzi F, Onori P, Franchitto A, Coufal M, Frampton G, Alvaro D, Lee SP, Marzioni M, Benedetti A, DeMorrow S Serotonin metabolism is dysregulated in cholangiocarcinoma, which has implications for tumor growth Cancer Res. 2008 Nov 15;68(22):9184-93 PUBMED
Kinney CM, Chandrasekharan UM, Yang L, Shen J, Kinter M, McDermott MS, Dicorleto PE Histone H3 as a novel substrate for MAP kinase phosphatase-1. Am J Physiol Cell Physiol. 2009 Feb;296(2):C242-9. Epub 2008 Nov 19. PUBMED
Izem L, Morton RE. Molecular cloning of hamster lipid transfer inhibitor protein (apolipoprotein F) and regulation of its expression by hyperlipidemia. J Lipid Res. 2008 Nov 13. [Epub ahead of print] PUBMED
Bafna S, Singh AP, Moniaux N, Eudy JD, Meza JL, Batra SK. MUC4, a multifunctional transmembrane glycoprotein, induces oncogenic transformation of NIH3T3 mouse fibroblast cells. Cancer Res. 2008 Nov 15;68(22):9231-8 PUBMED
Ch閞et C, Gervais A, Lelli A, Colin C, Amar L, Ravassard P, Mallet J, Cumano A, Krause KH, Mallat M. Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase. J Neurosci. 2008 Nov 12;28(46):12039-51 PUBMED
Venkatesan N, Barr?L, Magdalou J, Mainard D, Netter P, Fournel-Gigleux S, Ouzzine M. Modulation of xylosyltransferase I expression provides a mechanism regulating glycosaminoglycan chain synthesis during cartilage destruction and repair. FASEB J. 2008 Nov 10. [Epub ahead of print] PUBMED
Su G, Blaine SA, Qiao D, Friedl A. Membrane type 1 matrix metalloproteinase-mediated stromal syndecan-1 shedding stimulates breast carcinoma cell proliferation. Cancer Res. 2008 Nov 15;68(22):9558-65 PUBMED
Gobejishvili L, Barve S, Joshi-Barve S, McClain C Enhanced PDE4B expression augments LPS-inducible TNF expression in ethanol-primed monocytes: relevance to alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol. 2008 Oct;295(4):G718-24. Epub 2008 Aug 7. PUBMED
Nieves-Cintr髇 M, Amberg GC, Navedo MF, Molkentin JD, Santana LF. The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15623-8. Epub 2008 Oct 1 PUBMED
Nguyen KD, Fohner A, Booker JD, Dong C, Krensky AM, Nadeau KC. XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma. J Immunol. 2008 Oct 15;181(8):5386-95. PUBMED
Lovren F, Pan Y, Quan A, Teoh H, Wang G, Shukla PC, Levitt KS, Oudit GY, Al-Omran M, Stewart DJ, Slutsky AS, Peterson MD, Backx PH, Penninger JM, Verma S. Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1377-84. Epub 2008 Jul 25 PUBMED
Landgren H, Blixt A, Carlsson P Persistent FoxE3 expression blocks cytoskeletal remodeling and organelle degradation during lens fiber differentiation. Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4269-77. Epub 2008 Jun 6 PUBMED
Asprodites N, Zheng L, Geng D, Velasco-Gonzalez C, Sanchez-Perez L, Davila E. Engagement of Toll-like receptor-2 on cytotoxic T-lymphocytes occurs in vivo and augments antitumor activity. FASEB J. 2008 Oct;22(10):3628-37. Epub 2008 Jun 27 PUBMED
Singh PK, Behrens ME, Eggers JP, Cerny RL, Bailey JM, Shanmugam K, Gendler SJ, Bennett EP, Hollingsworth MA Phosphorylation of MUC1 by Met modulates interaction with p53 and MMP1 expression. J Biol Chem. 2008 Oct 3;283(40):26985-95. Epub 2008 Jul 14. PUBMED
Nawrocki ST, Carew JS, Maclean KH, Courage JF, Huang P, Houghton JA, Cleveland JL, Giles FJ, McConkey DJ. Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA. Blood. 2008 Oct 1;112(7):2917-26. Epub 2008 Jul 18 PUBMED
Conti HR, Shen F, Nayyar N, Stocum E, Sun JN, Lindemann MJ, Ho AW, Hai JH, Yu JJ, Jung JW, Filler SG, Masso-Welch P, Edgerton M, Gaffen SL. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J Exp Med. 2009 Feb 9. [Epub ahead of print] PUBMED
Conti HR, Shen F, Nayyar N, Stocum E, Sun JN, Lindemann MJ, Ho AW, Hai JH, Yu JJ, Jung JW, Filler SG, Masso-Welch P, Edgerton M, Gaffen SL. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J Exp Med. 2009 Feb 9. [Epub ahead of print] PUBMED
Robinson K, Kenefeck R, Pidgeon EL, Shakib S, Patel S, Polson RJ, Zaitoun AM, Atherton JC. Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses. Gut. 2008 Oct;57(10):1375-85. Epub 2008 May 8. PUBMED
Fischer J, Suire C, Hale-Donze H. Toll-like receptor 2 recognition of the microsporidia Encephalitozoon spp. induces nuclear translocation of NF-kappaB and subsequent inflammatory responses. Infect Immun. 2008 Oct;76(10):4737-44. Epub 2008 Aug 4. PUBMED
Fischer J, Suire C, Hale-Donze H. Toll-like receptor 2 recognition of the microsporidia Encephalitozoon spp. induces nuclear translocation of NF-kappaB and subsequent inflammatory responses. Infect Immun. 2008 Oct;76(10):4737-44. Epub 2008 Aug 4. PUBMED
Rappa G, Fodstad O, Lorico A. The stem cell-associated antigen CD133 (Prominin-1) is a Molecular Therapeutic Target for Metastatic Melanoma. Stem Cells. 2008 Sep 18. [Epub ahead of print] PUBMED
Kryczek I, Bruce AT, Gudjonsson JE, Johnston A, Aphale A, Vatan L, Szeliga W, Wang Y, Liu Y, Welling TH, Elder JT, Zou W. Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis. J Immunol. 2008 Oct 1;181(7):4733-41. PUBMED
Babbin BA, Laukoetter MG, Nava P, Koch S, Lee WY, Capaldo CT, Peatman E, Severson EA, Flower RJ, Perretti M, Parkos CA, Nusrat A. Annexin A1 regulates intestinal mucosal injury, inflammation, and repair. J Immunol. 2008 Oct 1;181(7):5035-44. PUBMED
Kihara Y, Yanagida K, Masago K, Kita Y, Hishikawa D, Shindou H, Ishii S, Shimizu T. Platelet-activating factor production in the spinal cord of experimental allergic encephalomyelitis mice via the group IVA cytosolic phospholipase A2-lyso-PAFAT axis. J Immunol. 2008 Oct 1;181(7):5008-14. PUBMED
Lee HH, Hoeman CM, Hardaway JC, Guloglu FB, Ellis JS, Jain R, Divekar R, Tartar DM, Haymaker CL, Zaghouani H. Delayed maturation of an IL-12-producing dendritic cell subset explains the early Th2 bias in neonatal immunity. J Exp Med. 2008 Sep 29;205(10):2269-80. Epub 2008 Sep 1. PUBMED
Buchner M, Fuchs S, Prinz G, Pfeifer D, Bartholome K, Burger M, Chevalier N, Vallat L, Timmer J, Gribben JG, Jumaa H, Veelken H, Dierks C, Zirlik K. Spleen tyrosine kinase is overexpressed and represents a potential therapeutic Cancer Res. 2009 Jul 1;69(13):5424-32. Epub 2009 Jun 23.PUBMED
Block K, Gorin Y, Abboud HE. Subcellular localization of Nox4 and regulation in diabetes. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14385-90. Epub 2009 Aug 17.PUBMED
Song L, Li Y, Wang K, Wang YZ, Molotkov A, Gao L, Zhao T, Yamagami T, Wang Y, Gan Q, Pleasure DE, Zhou CJ. Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion. Development. 2009 Sep;136(18):3161-71.PUBMED
Cabelof DC, Patel HV, Chen Q, van Remmen H, Matherly LH, Ge Y, Taub JW. Mutational spectrum at GATA1 provides insights into mutagenesis and Blood. 2009 Sep 24;114(13):2753-63. Epub 2009 Jul 24.PUBMED
Bexfield NA, Parcell AC, Nelson WB, Foote KM, Mack GW. Adaptations to high-intensity intermittent exercise in rodents. J Appl Physiol. 2009 Sep;107(3):749-54. Epub 2009 Jul 16.PUBMED
Liu Y, Zhu L, Fatheree NY, Liu X, Pacheco SE, Tatevian N, Rhoads JM. Changes in intestinal Toll-like receptors and cytokines precede histological Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G442-50. Epub 2009 JulPUBMED
Bodarky CL, Halene TB, Ehrlichman RS, Banerjee A, Ray R, Hahn CG, Jonak G, Siegel SJ. Novel environment and GABA agonists alter event-related potentials in J Pharmacol Exp Ther. 2009 Oct;331(1):308-18. Epub 2009 Jul 14.PUBMED
Jones OY, Lacson A, Zeng X, Jones JM, Katti K, Cahill RA, Ahmed AA. Long-term follow-up after non-myeloablative transplant of bone and marrow in BXSB Lupus. 2009 Aug;18(9):813-21.PUBMED
Zhu X, Wang M, Crump CH, Mishra A. An imbalance of esophageal effector and regulatory T cell subsets in experimental Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G550-8. Epub 2009 Jul 1.PUBMED
Helms MW, Kemming D, Contag CH, Pospisil H, Bartkowiak K, Wang A, Chang SY, Buerger H, Brandt BH. TOB1 is regulated by EGF-dependent HER2 and EGFR signaling, is highly Cancer Res. 2009 Jun 15;69(12):5049-56. Epub 2009 Jun 2.PUBMED
Pedroja BS, Kang LE, Imas AO, Carmeliet P, Bernstein AM. Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and J Biol Chem. 2009 Jul 31;284(31):20708-17. Epub 2009 Jun 1.PUBMED
Kumar P, Pandey KN. Cooperative activation of Npr1 gene transcription and expression by interaction Hypertension. 2009 Jul;54(1):172-8. Epub 2009 Jun 1.PUBMED
Ramamoorthy S, Donohue M, Buck M. Decreased Jun-D and myogenin expression in muscle wasting of human cachexia. Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E392-401. Epub 2009 May 26.PUBMED
Merk M, Baugh J, Zierow S, Leng L, Pal U, Lee SJ, Ebert AD, Mizue Y, Trent JO, Mitchell R, Nickel W, Kavathas PB, Bernhagen J, Bucala R. The Golgi-associated protein p115 mediates the secretion of macrophage migration J Immunol. 2009 Jun 1;182(11):6896-906.PUBMED
Merk M, Baugh J, Zierow S, Leng L, Pal U, Lee SJ, Ebert AD, Mizue Y, Trent JO, Mitchell R, Nickel W, Kavathas PB, Bernhagen J, Bucala R. The Golgi-associated protein p115 mediates the secretion of macrophage migration J Immunol. 2009 Jun 1;182(11):6896-906.PUBMED
Bucks CM, Norton JA, Boesteanu AC, Mueller YM, Katsikis PD. Chronic antigen stimulation alone is sufficient to drive CD8+ T cell exhaustion. J Immunol. 2009 Jun 1;182(11):6697-708.PUBMED
Bucks CM, Norton JA, Boesteanu AC, Mueller YM, Katsikis PD. Chronic antigen stimulation alone is sufficient to drive CD8+ T cell exhaustion. J Immunol. 2009 Jun 1;182(11):6697-708.PUBMED
Doisne JM, Bartholin L, Yan KP, Garcia CN, Duarte N, Le Luduec JB, Vincent D, Cyprian F, Horvat B, Martel S, Rimokh R, Losson R, Benlagha K, Marie JC. iNKT cell development is orchestrated by different branches of TGF-beta J Exp Med. 2009 Jun 8;206(6):1365-78. Epub 2009 May 18.PUBMED
Sundstrom JB, Hair GA, Ansari AA, Secor WE, Gilfillan AM, Metcalfe DD, Kirshenbaum AS. IgE-FcepsilonRI interactions determine HIV coreceptor usage and susceptibility to J Immunol. 2009 May 15;182(10):6401-9.PUBMED
Matsushima H, Tanaka H, Mizumoto N, Takashima A. Identification of crassin acetate as a new immunosuppressant triggering heme Blood. 2009 Jul 2;114(1):64-73. Epub 2009 Apr 28.PUBMED
Vlotides G, Cooper O, Chen YH, Ren SG, Greenman Y, Melmed S. Heregulin regulates prolactinoma gene expression. Cancer Res. 2009 May 15;69(10):4209-16. Epub 2009 Apr 28.PUBMED
Mancinelli R, Onori P, Gaudio E, DeMorrow S, Franchitto A, Francis H, Glaser S, Carpino G, Venter J, Alvaro D, Kopriva S, White M, Kossie A, Savage J, Alpini G. Follicle-stimulating hormone increases cholangiocyte proliferation by an Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G11-26. Epub 2009 AprPUBMED
Rhoads RP, Johnson RM, Rathbone CR, Liu X, Temm-Grove C, Sheehan SM, Hoying JB, Allen RE. Satellite cell-mediated angiogenesis in vitro coincides with a functional Am J Physiol Cell Physiol. 2009 Jun;296(6):C1321-8. Epub 2009 Apr 22.PUBMED
Ben-Shachar S, Chahrour M, Thaller C, Shaw CA, Zoghbi HY. Mouse models of MeCP2 disorders share gene expression changes in the cerebellum Hum Mol Genet. 2009 Jul 1;18(13):2431-42. Epub 2009 Apr 15.PUBMED
Simanainen U, McNamara K, Gao YR, Handelsman DJ. Androgen sensitivity of prostate epithelium is enhanced by postnatal androgen Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1335-43. Epub 2009 Apr 14.PUBMED
Weaver KL, Ivester P, Seeds M, Case LD, Arm JP, Chilton FH. Effect of dietary fatty acids on inflammatory gene expression in healthy humans. J Biol Chem. 2009 Jun 5;284(23):15400-7. Epub 2009 Apr 9.PUBMED
Shen Z, Ajmo JM, Rogers CQ, Liang X, Le L, Murr MM, Peng Y, You M. Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-alpha Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1047-53. Epub 2009 MarPUBMED
Kaposi-Novak P, Libbrecht L, Woo HG, Lee YH, Sears NC, Coulouarn C, Conner EA, Factor VM, Roskams T, Thorgeirsson SS. Central role of c-Myc during malignant conversion in human hepatocarcinogenesis. Cancer Res. 2009 Apr 1;69(7):2775-82. Epub 2009 Mar 10.PUBMED
Lobsiger CS, Boillee S, McAlonis-Downes M, Khan AM, Feltri ML, Yamanaka K, Cleveland DW. Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4465-70. Epub 2009 Feb 27.PUBMED
Xin H, Zhang C, Herrmann A, Du Y, Figlin R, Yu H. Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis Cancer Res. 2009 Mar 15;69(6):2506-13. Epub 2009 Feb 24.PUBMED
Maeda K, Malykhin A, Teague-Weber BN, Sun XH, Farris AD, Coggeshall KM. Interleukin-6 aborts lymphopoiesis and elevates production of myeloid cells in Blood. 2009 May 7;113(19):4534-40. Epub 2009 Feb 17.PUBMED
Liao Y, Plummer NW, George MD, Abramowitz J, Zhu MX, Birnbaumer L. A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3202-6. Epub 2009 Feb 12.PUBMED
Eid AA, Gorin Y, Fagg BM, Maalouf R, Barnes JL, Block K, Abboud HE. Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH Diabetes. 2009 May;58(5):1201-11. Epub 2009 Feb 10.PUBMED
Beales IL, Ogunwobi OO. Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and J Mol Endocrinol. 2009 Apr;42(4):305-18. Epub 2009 Jan 19.PUBMED
Delibegovic M, Zimmer D, Kauffman C, Rak K, Hong EG, Cho YR, Kim JK, Kahn BB, Neel BG, Bence KK. Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves Diabetes. 2009 Mar;58(3):590-9. Epub 2008 Dec 15.PUBMED
Padmalayam I, Hasham S, Saxena U, Pillarisetti S. Lipoic acid synthase (LASY): a novel role in inflammation, mitochondrial Diabetes. 2009 Mar;58(3):600-8. Epub 2008 Dec 15.PUBMED
Boden G, Silviera M, Smith B, Cheung P, Homko C. Acute tissue injury caused by subcutaneous fat biopsies produces endoplasmic reticulum stress. J Clin Endocrinol Metab. 2010 Jan;95(1):349-52. Epub 2009 Nov 6.PUBMED
Sinha S, Dutta S, Datta K, Ghosh AK, Mukhopadhyay D. Von Hippel-Lindau gene product modulates TIS11B expression in renal cell carcinoma: impact on vascular endothelial growth factor expression in hypoxia. J Biol Chem. 2009 Nov 20;284(47):32610-8. Epub 2009 Sep 28.PUBMED
Lee VW, Qin X, Wang Y, Zheng G, Wang Y, Wang Y, Ince J, Tan TK, Kairaitis LK, Alexander SI, Harris DC. The CD40-CD154 co-stimulation pathway mediates innate immune injury in adriamycin nephrosis. Nephrol Dial Transplant. 2009 Nov 4. [Epub ahead of print]PUBMED
Paruchuri S, Tashimo H, Feng C, Maekawa A, Xing W, Jiang Y, Kanaoka Y, Conley P, Boyce JA. Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor. J Exp Med. 2009 Oct 26;206(11):2543-55. Epub 2009 Oct 12.PUBMED
Castellaneta A, Sumpter TL, Chen L, Tokita D, Thomson AW. NOD2 ligation subverts IFN-alpha production by liver plasmacytoid dendritic cells and inhibits their T Cell Allostimulatory activity via B7-H1 up-regulation. J Immunol. 2009 Dec 1;183(11):6922-32. Epub 2009 Nov 4.PUBMED
Vispé S, DeVries L, Créancier L, Besse J, Bréand S, Hobson DJ, Svejstrup JQ, Annereau JP, Cussac D, Dumontet C, Guilbaud N, Barret JM, Bailly C. Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA. Mol Cancer Ther. 2009 Oct;8(10):2780-90. Epub 2009 Oct 6.PUBMED
Collins CE, La DT, Yang HT, Massin F, Gibot S, Faure G, Stohl W Elevated synovial expression of triggering receptor expressed on myeloid cells 1 in patients with septic arthritis or rheumatoid arthritis. Ann Rheum Dis. 2009 Nov;68(11):1768-74. Epub 2008 Dec 3PUBMED
Palakodeti A, Lucas I, Jiang Y, Young DJ, Fernald AA, Karrison T, Le Beau MM Impaired replication dynamics at the FRA3B common fragile site. Hum Mol Genet. 2010 Jan 1;19(1):99-110.PUBMED
Wu M, McClellan SA, Barrett RP, Zhang Y, Hazlett LD. Beta-defensins 2 and 3 together promote resistance to Pseudomonas aeruginosa keratitis. J Immunol. 2009 Dec 15;183(12):8054-60.PUBMED
Prins JM, Park S, Lurie DI. Decreased expression of the voltage-dependent anion channel in differentiated pc-12 and SH-SY5Y cells following low-level Pb exposure. Toxicol Sci. 2010 Jan;113(1):169-76. Epub 2009 Oct 12.PUBMED
Lu L, Li P, Yang C, Kurth T, Misale M, Skelton MM, Moreno C, Roman RJ, Greene AS, Jacob HJ, Lazar J, Liang M, Cowley Jr AW. Dynamic convergence and divergence of renal genomic and biological pathways in protection from Dahl salt-sensitive hypertension. Physiol Genomics.. [Epub ahead of print]PUBMED
Francis H, Onori P, Gaudio E, Franchitto A, DeMorrow S, Venter J, Kopriva S, Carpino G, Mancinelli R, White M, Meng F, Vetuschi A, Sferra R, Alpini G. H3 histamine receptor-mediated activation of protein kinase Calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo. Mol Cancer Res. 2009 Oct;7(10):1704-13. Epub 2009 Oct 13.PUBMED

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RT² SYBR Green qPCR Master Mixes

 
ABI / Stratagene: SYBR Green / ROX
Choi YB, Nicholas J. Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines. J Virol. 2008 Jul;82(13):6501-13. Epub 2008 Apr 23.  PUBMED
Fleming AB, Pennings S. Tup1-Ssn6 and Swi-Snf remodelling activities influence long-range chromatin organization upstream of the yeast SUC2 gene Nucleic Acids Res. 2007;35(16):5520-31. Epub 2007 Aug 17 PUBMED
  
Gregory-Evans CY, Moosajee M, Hodges MD, Mackay DS, Game L, Vargesson N, Bloch-Zupan A, Rüschendorf F, Santos-Pinto L, Wackens G, Gregory-Evans K SNP genome scanning localizes oto-dental syndrome to chromosome 11q13 and microdeletions at this locus implicate FGF3 in dental and inner-ear disease and FADD in ocular coloboma Hum Mol Genet. 2007 Oct 15;16(20):3482-93. Epub 2007 Jul 25. PUBMED
  
Kim YS, Kang HS, Herbert R, Beak JY, Collins JB, Grissom SF, Jetten AM. Kruppel-like zinc finger protein glis2 is essential for the maintenance of normal renal functions. Mol Cell Biol. 2008 Apr;28(7):2358-67. Epub 2008 Jan 28  PUBMED
Ma X, Shah Y, Cheung C, Guo GL, Feigenbaum L, Krausz KW, Idle JR, Gonzalez FJ. The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A. Drug Metab Dispos. 2007 Feb;35(2):194-200. Epub 2006 Nov 8. PUBMED
  
Ma X, Shah YM, Guo GL, Wang T, Krausz KW, Idle JR, Gonzalez FJ Rifaximin is a gut-specific human pregnane X receptor activator J Pharmacol Exp Ther. 2007 Jul;322(1):391-8. Epub 2007 Apr 18. PUBMED
  
Sama MA, Mathis DM, Furman JL, Mohmmad Abdul H, Artiushin IA, Kraner SD, Norris CM. Interleukin-1beta -dependent signaling between astrocytes and neurons depends critically on astrocytic calcineurin/nfat activity. J Biol Chem. 2008 Jun 9. [Epub ahead of print]  PUBMED
Scuto A, Kirschbaum M, Kowolik C, Kretzner L, Juhasz A, Atadja P, Pullarkat V, Bhatia R, Forman S, Yen Y, Jove R The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells. Blood. 2008 May 15;111(10):5093-100. Epub 2008 Mar 18  PUBMED
Secchiero P, Corallini F, Rimondi E, Chiaruttini C, di Iasio MG, Rustighi A, Del Sal G, Zauli G. Activation of the p53 pathway down-regulates the osteoprotegerin (OPG) expression and release by vascular endothelial cells. Blood. 2007 Nov 13; [Epub ahead of print] PUBMED
  
Smed-S?ensen A, Moll M, Cheng TY, Lor?K, Norlin AC, Perbeck L, Moody DB, Spetz AL, Sandberg JK IgG regulates the CD1 expression profile and lipid antigen-presenting function in human dendritic cells via FcgammaRIIa Blood. 2008 May 15;111(10):5037-46. Epub 2008 Mar 12  PUBMED
Song Z, Deaciuc I, Zhou Z, Song M, Chen T, Hill D, McClain CJ. Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis. Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G894-902. Epub 2007 Aug 16. PUBMED
  
Sung B, Pandey MK, Ahn KS, Yi T, Chaturvedi MM, Liu M, Aggarwal BB Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis Blood. 2008 May 15;111(10):4880-91. Epub 2008 Mar 18  PUBMED
Wang T, Ma X, Krausz KW, Idle JR, Gonzalez FJ. Role of pregnane X receptor in control of all-trans retinoic acid (ATRA) metabolism and its potential contribution to ATRA resistance. J Pharmacol Exp Ther. 2007 Oct 25; [Epub ahead of print] PUBMED
  
Weaver IC, D'Alessio AC, Brown SE, Hellstrom IC, Dymov S, Sharma S, Szyf M, Meaney MJ. The transcription factor nerve growth factor-inducible protein a mediates epigenetic programming: altering epigenetic marks by immediate-early genes. J Neurosci. 2007 Feb 14;27(7):1756-68. PUBMED
  
White DL, Saunders VA, Dang P, Engler J, Venables A, Zrim S, Zannettino A, Lynch K, Manley PW, Hughes T. Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity: higher doses of imatinib may overcome the negative impact of low OCT-1 activity. Blood. 2007 Dec 1;110(12):4064-72. Epub 2007 Aug 30 PUBMED
  
Rhee DY, Zhao XQ, Francis RJ, Huang GY, Mably JD, Lo CW. Connexin 43 regulates epicardial cell polarity and migration in coronary vascular Development. 2009 Sep;136(18):3185-93.PUBMED
Hanna M, Liu H, Amir J, Sun Y, Morris SW, Siddiqui MA, Lau LF, Chaqour B. Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the J Biol Chem. 2009 Aug 21;284(34):23125-36. Epub 2009 Jun 20.PUBMED
Collado MC, Donat E, Ribes-Koninckx C, Calabuig M, Sanz Y. Specific duodenal and faecal bacterial groups associated with paediatric coeliac J Clin Pathol. 2009 Mar;62(3):264-9. Epub 2008 Nov 7.PUBMED
Cheng J, Ma X, Krausz KW, Idle JR, Gonzalez FJ. Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance Drug Metab Dispos. 2009 Aug;37(8):1611-21. Epub 2009 May 21.PUBMED
Wahl C, Wegenka UM, Leithauser F, Schirmbeck R, Reimann J. IL-22-dependent attenuation of T cell-dependent (ConA) hepatitis in herpes virus J Immunol. 2009 Apr 15;182(8):4521-8.PUBMED
Bio-Rad: SYBR Green / Fluorescein
Chiao E, Elazar M, Xing Y, Xiong A, Kmet M, Millan MT, Glenn JS, Wong WH, Baker J. Isolation and Transcriptional Profiling of Purified Hepatic Cells Derived from Human Embryonic Stem Cells. Stem Cells. 2008 Jun 5. [Epub ahead of print]  PUBMED
Han L, Lee DH, Szab?PE CTCF is the master organizer of domain-wide allele-specific chromatin at the H19/Igf2 imprinted region. Mol Cell Biol. 2008 Feb;28(3):1124-35. Epub 2007 Nov 26  PUBMED
L? K, Culbertson M, Bradke F, Tessier-Lavigne M, Tuszynski MH. Netrin-1 is a novel myelin-associated inhibitor to axon growth. J Neurosci. 2008 Jan 30;28(5):1099-108  PUBMED
Stark K, Wu ZL, Bartleson CJ, Guengerich FP. mRNA Distribution and Heterologous Expression of Orphan Cytochrome P450 20A1. Drug Metab Dispos. 2008 Jun 9. [Epub ahead of print]  PUBMED
Qin S, Liu T, Kamanna VS, Kashyap ML Pioglitazone stimulates apolipoprotein A-I production without affecting HDL removal in HepG2 cells: involvement of PPAR-alpha. Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2428-34. Epub 2007 Sep 13. PUBMED
  
Menze MA, Boswell L, Toner M, Hand SC. Occurrence of mitochondria-targeted Late Embryogenesis Abundant (LEA) gene in J Biol Chem. 2009 Apr 17;284(16):10714-9. Epub 2009 Feb 19.PUBMED
Larman BW, Karolak MJ, Adams DC, Oxburgh L. Chordin-like 1 and twisted gastrulation 1 regulate BMP signaling following kidney J Am Soc Nephrol. 2009 May;20(5):1020-31. Epub 2009 Apr 8.PUBMED
Others: SYBR Green
Brown SE, Szyf M. Epigenetic programming of the rRNA promoter by MBD3 Mol Cell Biol. 2007 Jul;27(13):4938-52. Epub 2007 Apr 23. PUBMED
  
Carreras E, Turner S, Paharkova-Vatchkova V, Mao A, Dascher C, Kovats S. Estradiol acts directly on bone marrow myeloid progenitors to differentially regulate GM-CSF or Flt3 ligand-mediated dendritic cell differentiation J Immunol. 2008 Jan 15;180(2):727-38.  PUBMED
Emmons J, Townley-Tilson WH, Deleault KM, Skinner SJ, Gross RH, Whitfield ML, Brooks SA Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation. RNA. 2008 May;14(5):888-902. Epub 2008 Mar 26.  PUBMED
Hernandez Y, Shpak M, Duarte TT, Mendez TL, Maldonado RA, Roychowdhury S, Rodrigues ML, Das S. Novel role of sphingolipid synthesis genes in regulating giardial encystation. Infect Immun. 2008 Jul;76(7):2939-49. Epub 2008 Apr 21.  PUBMED
Hu W, Mahavadi S, Li F, Murthy KS. Up-Regulation of RGS4 and Down-Regulation of CPI-17 Mediate Inhibition of Colonic Muscle Contraction by Interleukin-1{beta} Am J Physiol Cell Physiol. 2007 Oct 24; [Epub ahead of print] PUBMED
  
Kim JS, Bailey MJ, Ho AK, Møller M, Gaildrat P, Klein DC. Daily rhythm in pineal phosphodiesterase (PDE) activity reflects adrenergic/3',5'-cyclic adenosine 5'-monophosphate induction of the PDE4B2 variant. Endocrinology. 2007 Apr;148(4):1475-85. Epub 2007 Jan 4. PUBMED
  
Kopp JL, Ormsbee BD, Desler M, Rizzino A. Small Increases in the Level of Sox2 Trigger the Differentiation of Mouse Embryonic Stem Cells. Stem Cells. 2008 Jan 31 [Epub ahead of print]  PUBMED
Kopp JL, Wilder PJ, Desler M, Kinarsky L, Rizzino A. Different domains of the transcription factor ELF3 are required in a promoter-specific manner and multiple domains control its binding to DNA. J Biol Chem. 2007 Feb 2;282(5):3027-41. Epub 2006 Dec 5. PUBMED
  
Peyrou M, Hanna PE, Cribb AE. Cisplatin, gentamicin, and p-aminophenol induce markers of endoplasmic reticulum stress in the rat kidneys. Toxicol Sci. 2007 Sep;99(1):346-53. Epub 2007 Jun 12. PUBMED
  
Robert R, Carlile GW, Pavel C, Liu N, Anjos SM, Liao J, Luo Y, Zhang D, Thomas DY, Hanrahan JW. Structural analogue of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol Pharmacol. 2007 Nov 1; [Epub ahead of print PUBMED
  
Seijffers R, Mills CD, Woolf CJ. ATF3 increases the intrinsic growth state of DRG neurons to enhance peripheral nerve regeneration. J Neurosci. 2007 Jul 25;27(30):7911-20. PUBMED
  
Soundararajan R, Wishart AD, Rupasinghe HP, Arcellana-Panlilio M, Nelson CM, Mayne M, Robertson GS. Quercetin-3-glucoside protects neuroblastoma (SH-SY5Y) cells in vitro against oxidative damage by inducing SREBP-2 mediated cholesterol biosynthesis. J Biol Chem. 2007 Nov 20 [Epub ahead of print]. PUBMED
  
Stepanova V, Lebedeva T, Kuo A, Yarovoi S, Tkachuk S, Zaitsev S, Bdeir K, Dumler I, Marks MS, Parfyonova Y, Tkachuk VA, Higazi AA, Cines DB. Nuclear translocation of urokinase-type plasminogen activator. Blood. 2008 Jul 1;112(1):100-10. Epub 2008 Mar 12.  PUBMED
Wang T, Ma X, Krausz KW, Idle JR, Gonzalez FJ. Role of pregnane X receptor in control of all-trans retinoic acid (ATRA) metabolism and its potential contribution to ATRA resistance. J Pharmacol Exp Ther. 2008 Feb;324(2):674-84. Epub 2007 Oct 25.  PUBMED
Wu S, Peng J, Duncan MR, Kasisomayajula K, Grotendorst G, Bancalari E ALK-5 Mediates Endogenous and TGF-{beta}1-induced Expression of CTGF in Embryonic Lung. Am J Respir Cell Mol Biol. 2006 Dec 29; [Epub ahead of print]. PUBMED
  
Yan Y, Black CP, Cao PT, Haferbier JL, Kolb RH, Spieker RS, Ristow AM, Cowan KH. Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1. Cancer Res. 2008 Jul 1;68(13):5113-21. PUBMED
You M, Liang X, Ajmo JM, Ness GC Involvement of mammalian sirtuin 1 in the action of ethanol in the liver. Am J Physiol Gastrointest Liver Physiol. 2008 Apr;294(4):G892-8. Epub 2008 Jan 31  PUBMED
Zhang MY, Wu X, Lee AJ, Jin W, Chang M, Wright A, Imaizumi T, Sun SC. Regulation of I{kappa}B Kinase-related Kinases and Antiviral Responses by Tumor Suppressor CYLD. J Biol Chem. 2008 Jul 4;283(27):18621-6. Epub 2008 May 8.  PUBMED
Zolfaghari R, Cifelli CJ, Lieu SO, Chen Q, Li NQ, Ross AC. Lipopolysaccharide opposes the induction of CYP26A1 and CYP26B1 gene expression by retinoic acid in the rat liver in vivo. Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1029-36. Epub 2006 Dec 21 PUBMED
Liu D, Kebaier C, Pakpour N, Capul AA, Beverley SM, Scott P, Uzonna JE. Leishmania major phosphoglycans influence the host early immune response by Infect Immun. 2009 Aug;77(8):3272-83. Epub 2009 Jun 1.PUBMED
Ho LH, Taylor R, Dorstyn L, Cakouros D, Bouillet P, Kumar S. A tumor suppressor function for caspase-2. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5336-41. Epub 2009 Mar 11.PUBMED
Suh HC, Ji M, Gooya J, Lee M, Klarmann KD, Keller JR. Cell-nonautonomous function of Id1 in the hematopoietic progenitor cell niche. Blood. 2009 Aug 6;114(6):1186-95. Epub 2009 May 28.PUBMED
Cheng SM, Li JC, Lin SS, Lee DC, Liu L, Chen Z, Lau AS. HIV-1 transactivator protein induction of suppressor of cytokine signaling-2 Blood. 2009 May 21;113(21):5192-201. Epub 2009 Mar 11.PUBMED
Evans RT, Seasholtz AF. Soluble corticotropin-releasing hormone receptor 2alpha splice variant is Endocrinology. 2009 Sep;150(9):4191-202. Epub 2009 Jun 11.PUBMED

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Oligo GEArray DNA Microarrays

 
Angiogenesis
Lazar AJ, Das P, Tuvin D, Korchin B, Zhu Q, Jin Z, Warneke CL, Zhang PS, Hernandez V, Lopez-Terrada D, Pisters PW, Pollock RE, Lev D Angiogenesis-promoting gene patterns in alveolar soft part sarcoma Clin Cancer Res. 2007 Dec 15;13(24):7314-21  PUBMED
Yi M, Schnitzer JE. Impaired tumor growth, metastasis, angiogenesis and wound healing in annexin A1-null mice. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17886-91. Epub 2009 Oct 1. PUBMED
Gueron G, De Siervi A, Ferrando M, Salierno M, De Luca P, Elguero B, Meiss R, Navone N, Vazquez ES. Critical role of endogenous heme oxygenase 1 as a tuner of the invasive potential of prostate cancer cells. Mol Cancer Res. 2009 Nov;7(11):1745-55. Epub 2009 Nov 10. PUBMED
 Apoptosis
Azuma T, Yao S, Zhu G, Flies AS, Flies SJ, Chen L. B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood. 2008 Apr 1;111(7):3635-43. Epub 2008 Jan 25.  PUBMED
Leng Y, Chuang DM. Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity. J Neurosci. 2006 Jul 12;26(28):7502-12. PUBMED
  
Low GK, Fok ED, Ting AP, Hande MP. Oxidative damage induced genotoxic effects in human fibroblasts from Xeroderma Pigmentosum group A patients. Int J Biochem Cell Biol. 2008 May 21. [Epub ahead of print]  PUBMED
Nefedova Y, Sullivan DM, Bolick SC, Dalton WS, Gabrilovich DI Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy. Blood. 2008 Feb 15;111(4):2220-9. Epub 2007 Nov 26.  PUBMED
Pandey J, Umphress SM, Kang Y, Angdisen J, Naumova A, Mercer KL, Jacks T, Jakowlew SB Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- 1 haploinsufficiency. Carcinogenesis. 2007 Dec;28(12):2589-96. Epub 2007 Aug 8  PUBMED
Staiger K, Staiger H, Weigert C, Haas C, Haring HU, Kellerer M. Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor-kappaB activation. Diabetes. 2006 Nov;55(11):3121-6. PUBMED
  
Yan H, Frost P, Shi Y, Hoang B, Sharma S, Fisher M, Gera J, Lichtenstein A. Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis Cancer Res. 2006 Feb 15;66(4):2305-13. PUBMED
 
Zhang M, Marshall B, Atherton SS. Murine cytomegalovirus infection and apoptosis in organotypic retinal cultures Invest Ophthalmol Vis Sci. 2008 Jan;49(1):295-303  PUBMED
Zhou J, Liu M, Zhai Y, Xie W The Anti-Apoptotic Role of Pregnane X Receptor in Human Colon Cancer Cells Mol Endocrinol. 2007 Dec 20 [Epub ahead of print]  PUBMED
Hu G, Barnes BJ. IRF-5 Is a Mediator of the Death Receptor-induced Apoptotic Signaling Pathway. J Biol Chem. 2009 Jan 30;284(5):2767-77. Epub 2008 Nov 20 PUBMED
Li H, Ray G, Yoo BH, Erdogan M, Rosen KV. Down-regulation of Death-associated Protein Kinase-2 Is Required for {beta}-Catenin-induced Anoikis Resistance of Malignant Epithelial Cells. J Biol Chem. 2009 Jan 23;284(4):2012-22. Epub 2008 Oct 27 PUBMED
Ottewell PD, M鰊kk鰊en H, Jones M, Lefley DV, Coleman RE, Holen I. Antitumor effects of doxorubicin followed by zoledronic acid in a mouse model of breast cancer. J Natl Cancer Inst. 2008 Aug 20;100(16):1167-78. PUBMED
Wright CJ, Zhuang T, La P, Yang G, Dennery PA Hyperoxia-Induced NF-{kappa}B Activation Occurs Via A Maturationally Sensitive Atypical Pathway. Am J Physiol Lung Cell Mol Physiol. 2008 Dec 12. [Epub ahead of print] PUBMED
Behl Y, Krothapalli P, Desta T, Roy S, Graves DT. FOXO1 plays an important role in enhanced microvascular cell apoptosis and Diabetes. 2009 Apr;58(4):917-25. Epub 2009 Jan 23.PUBMED
Ottewell PD, Woodward JK, Lefley DV, Evans CA, Coleman RE, Holen I. Anticancer mechanisms of doxorubicin and zoledronic acid in breast cancer tumor growth in bone. Mol Cancer Ther. 2009 Oct;8(10):2821-32. Epub 2009 Sep 29.PUBMED
Atherosclerosis
Harvey EJ, Li N, Ramji DP. Critical role for casein kinase 2 and phosphoinositide-3-kinase in the interferon-gamma-induced expression of monocyte chemoattractant protein-1 and other key genes implicated in atherosclerosis. Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):806-12. Epub 2007 Jan 25 PUBMED
 
Naiki Y, Sorrentino R, Wong MH, Michelsen KS, Shimada K, Chen S, Yilmaz A, Slepenkin A, Schr鰀er NW, Crother TR, Bulut Y, Doherty TM, Bradley M, Shaposhnik Z, Peterson EM, Tontonoz P, Shah PK, Arditi M TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis. J Immunol. 2008 Nov 15;181(10):7176-85 PUBMED
 
Breast Cancer & Estrogen Receptor Signaling
Telang U, Brazeau DA, Morris ME. Comparison of the effects of phenethyl isothiocyanate and sulforaphane on gene Exp Biol Med (Maywood). 2009 Mar;234(3):287-95. Epub 2009 Jan 14.PUBMED
Liu B, Ordonez-Ercan D, Fan Z, Huang X, Edgerton SM, Yang X, Thor AD. Estrogenic promotion of ErbB2 tyrosine kinase activity in mammary tumor cells requires activation of ErbB3 signaling. Mol Cancer Res. 2009 Nov;7(11):1882-92. Epub 2009 Oct 27. PUBMED
Cancer
Bryan BA, Dyson OF, Akula SM. Identifying cellular genes crucial for the reactivation of Kaposi's sarcoma-associated herpesvirus latency. J Gen Virol. 2006 Mar;87(Pt 3):519-29. PUBMED
 
Frommer KW, Reichenmiller K, Schutt BS, Hoeflich A, Ranke MB, Dodt G, Elmlinger MW. IGF-independent effects of IGFBP-2 on the human breast cancer cell line Hs578T. J Mol Endocrinol. 2006 Aug;37(1):13-23. PUBMED
 
Cancer PathwayFinder
Li H, Fan X, Kovi RC, Jo Y, Moquin B, Konz R, Stoicov C, Kurt-Jones E, Grossman SR, Lyle S, Rogers AB, Montrose M, Houghton J. Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice. Cancer Res. 2007 Nov 15;67(22):10889-98. PUBMED
Shao J, Washington MK, Saxena R, Sheng H Heterozygous disruption of the PTEN promotes intestinal neoplasia in APCmin/+ mouse: roles of osteopontin. Carcinogenesis. 2007 Dec;28(12):2476-83. Epub 2007 Aug 11  PUBMED
  
Cell Cycle
Jang SI, Lee EJ, Hart PS, Ramaswami M, Pallos D, Hart TC Germ line gain of function with SOS1 mutation in hereditary gingival fibromatosis. J Biol Chem. 2007 Jul 13;282(28):20245-55. Epub 2007 May 17. PUBMED
 
Klokk TI, Kilander A, Xi Z, Waehre H, Risberg B, Danielsen HE, Saatcioglu F. Kallikrein 4 is a proliferative factor that is overexpressed in prostate cancer. Cancer Res. 2007 Jun 1;67(11):5221-30 PUBMED
 
Pandey J, Umphress SM, Kang Y, Angdisen J, Naumova A, Mercer KL, Jacks T, Jakowlew SB Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- 1 haploinsufficiency. Carcinogenesis. 2007 Dec;28(12):2589-96. Epub 2007 Aug 8  PUBMED
Rubinek T, Chesnokova V, Wolf I, Wawrowsky K, Vlotides G, Melmed S Discordant proliferation and differentiation in pituitary tumor-transforming gene-null bone marrow stem cells. Am J Physiol Cell Physiol. 2007 Sep;293(3):C1082-92. Epub 2007 Jul 11 PUBMED
 
Lu J, Verma SC, Murakami M, Cai Q, Kumar P, Xiao B, Robertson ES. Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus J Virol. 2009 Jul;83(14):7129-41. Epub 2009 May 13.PUBMED
Liu L, Wang J, Zhao L, Nilsen J, McClure K, Wong K, Brinton RD. Progesterone increases rat neural progenitor cell cycle gene expression and Endocrinology. 2009 Jul;150(7):3186-96. Epub 2009 Apr 9.PUBMED
Ottewell PD, Woodward JK, Lefley DV, Evans CA, Coleman RE, Holen I. Anticancer mechanisms of doxorubicin and zoledronic acid in breast cancer tumor growth in bone. Mol Cancer Ther. 2009 Oct;8(10):2821-32. Epub 2009 Sep 29.PUBMED
Cell Surface Markers
Wang L, O'Leary H, Fortney J, Gibson LF. Ph+/VE-cadherin+ identifies a stem cell like population of acute lymphoblastic leukemia sustained by bone marrow niche cells. Blood. 2007 Nov 1;110(9):3334-44. Epub 2007 Jul 16. PUBMED
Chemokines & Receptors
Fischer J, West J, Agochukwu N, Suire C, Hale-Donze H. Induction of host chemotactic response by Encephalitozoon spp Infect Immun. 2007 Apr;75(4):1619-25. Epub 2006 Dec 18. PUBMED
 
Schenk S, Mal N, Finan A, Zhang M, Kiedrowski M, Popovic Z, McCarthy PM, Penn MS. Monocyte chemotactic protein-3 is a myocardial mesenchymal stem cell homing factor. Stem Cells. 2007 Jan;25(1):245-51. Epub 2006 Oct 19. PUBMED
 
Sinha I, Cho BS, Roelofs KJ, Stanley JC, Henke PK, Upchurch GR Jr Female gender attenuates cytokine and chemokine expression and leukocyte recruitment in experimental rodent abdominal aortic aneurysms. Ann N Y Acad Sci. 2006 Nov;1085:367-79 PUBMED
 
Son DS, Roby KF. Interleukin-1alpha-induced chemokines in mouse granulosa cells: impact on keratinocyte chemoattractant chemokine, a CXC subfamily. Mol Endocrinol. 2006 Nov;20(11):2999-3013. Epub 2006 Jul 6. PUBMED
 
Weiss ML, Anderson C, Medicetty S, Seshareddy KB, Weiss RJ, Vanderwerff I, Troyer D, McIntosh KR. Immune Properties of Human Umbilical Cord Wharton's Jelly-Derived Cells. Stem Cells. 2008 Aug 14. [Epub ahead of print] PUBMED
 
Cagigi A, Mowafi F, Phuong Dang LV, Tenner-Racz K, Atlas A, Grutzmeier S, Racz P, Chiodi F, Nilsson A. Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection. Blood. 2008 Dec 1;112(12):4401-10. Epub 2008 Sep 9. PUBMED
 
Yasuoka H, Yamaguchi Y, Feghali-Bostwick CA The Pro-fibrotic Factor IGFBP-5 Induces Lung Fibroblast and Mononuclear Cell Migration. Am J Respir Cell Mol Biol. 2009 Jan 8. [Epub ahead of print] PUBMED
 
Common Cytokines
Korshunov VA, Nikonenko TA, Tkachuk VA, Brooks A, Berk BC Interleukin-18 and macrophage migration inhibitory factor are associated with increased carotid intima-media thickening Arterioscler Thromb Vasc Biol. 2006 Feb;26(2):295-300. Epub 2005 Nov 17 PUBMED
Lee JK, Mathew SO, Vaidya SV, Kumaresan PR, Mathew PA. CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes. J Immunol. 2007 Oct 1;179(7):4672-8. PUBMED
 
Ou R, Zhang M, Huang L, Flavell RA, Koni PA, Moskophidis D. Regulation of immune response and inflammatory reactions against viral infection by VCAM-1. J Virol. 2008 Mar;82(6):2952-65. Epub 2008 Jan 23  PUBMED
Sinha I, Cho BS, Roelofs KJ, Stanley JC, Henke PK, Upchurch GR Jr Female gender attenuates cytokine and chemokine expression and leukocyte recruitment in experimental rodent abdominal aortic aneurysms. Ann N Y Acad Sci. 2006 Nov;1085:367-79 PUBMED
 
Coffelt SB, Tomchuck SL, Zwezdaryk KJ, Danka ES, Scandurro AB. Leucine leucine-37 uses formyl peptide receptor-like 1 to activate signal Mol Cancer Res. 2009 Jun;7(6):907-15. Epub 2009 Jun 2.PUBMED
Li C, Houser BL, Nicotra ML, Strominger JL. HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5767-72. Epub 2009 Mar 20.PUBMED
Gupta S, Maitra R, Young D, Gupta A, Sen S. Silencing the myotrophin gene by RNA interference leads to the regression of Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H627-36. Epub 2009 Jun 5.PUBMED
Jerde TJ, Bushman W. IL-1 induces IGF-dependent epithelial proliferation in prostate development and reactive hyperplasia. Sci Signal. 2009 Sep 1;2(86):ra49.PUBMED
Jerde TJ, Bushman W. IL-1 induces IGF-dependent epithelial proliferation in prostate development and reactive hyperplasia. Sci Signal. 2009 Sep 1;2(86):ra49.
Custom
Djamali A. Oxidative stress as a common pathway to chronic tubulointerstitial injury in kidney allografts. Am J Physiol Renal Physiol. 2007 Aug;293(2):F445-55. Epub 2007 Apr 25. PUBMED
 
Huang HS, Matevossian A, Whittle C, Kim SY, Schumacher A, Baker SP, Akbarian S Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters. J Neurosci. 2007 Oct 17;27(42):11254-62. PUBMED
Kushnir AS, Davido DJ, Schaffer PA. Role of nuclear factor Y in stress-induced activation of the herpes simplex virus type 1 ICP0 promoter. J Virol. 2010 Jan;84(1):188-200. PUBMED
Dendritic & Antigen Presenting Cells
Luo Y, Schwartz C, Shin S, Zeng X, Chen N, Wang Y, Yu X, Rao MS. A focused microarray to assess dopaminergic and glial cell differentiation from fetal tissue or embryonic stem cells Stem Cells. 2006 Apr;24(4):865-75. Epub 2005 Dec 15. PUBMED
 
Li X, Yang A, Huang H, Zhang X, Town J, Davis B, Cockcroft DW, Gordon JR. Induction of Th2 Cell Allergen Tolerance by IL-10-differentiated Regulatory Am J Respir Cell Mol Biol. 2009 Apr 16.PUBMED
DNA Damage Signaling
Chesnokova V, Zonis S, Rubinek T, Yu R, Ben-Shlomo A, Kovacs K, Wawrowsky K, Melmed S. Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth. Cancer Res. 2007 Nov 1;67(21):10564-72. PUBMED
Chesnokova V, Wong C, Zonis S, Gruszka A, Wawrowsky K, Ren SG, Benshlomo A, Yu R. Diminished pancreatic {beta} cell mass in securin-null mice is caused by {beta} cell apoptosis and senescence. Endocrinology. 2009 Feb 12. [Epub ahead of print] PUBMED
Extracellular Matrix & Adhesion Molecules
Hannan NJ, Salamonsen LA. CX3CL1 and CCL14 Regulate Extracellular Matrix and Adhesion Molecules in the Trophoblast: Potential Roles in Human Embryo Implantation. Biol Reprod. 2008 Jul;79(1):58-65. Epub 2008 Mar 26.  PUBMED
Khan ZA, Melero-Martin JM, Wu X, Paruchuri S, Boscolo E, Mulliken JB, Bischoff J. Endothelial progenitor cells from infantile hemangioma and umbilical cord blood display unique cellular responses to endostatin. Blood. 2006 Aug 1;108(3):915-21. PUBMED
Romain D, Sylvie BP, Johanna L, Alain M, Aurelie D, Fran?is-Xavier M, William H, Irfan R, Frank A. Laboratoire de Biochimie, Universit?de REIMS Champagne-Ardenne, CNRS UMR-6237, 51095 REIMS Cedex, France Biochim Biophys Acta. 2008 Jun 13. [Epub ahead of print] PUBMED
Taniwaki K, Fukamachi H, Komori K, Ohtake Y, Nonaka T, Sakamoto T, Shiomi T, Okada Y, Itoh T, Itohara S, Seiki M, Yana I. Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice. Cancer Res. 2007 May 1;67(9):4311-9 PUBMED
Sung SY, Hsieh CL, Law A, Zhau HE, Pathak S, Multani AS, Lim S, Coleman IM, Wu LC, Figg WD, Dahut WL, Nelson P, Lee JK, Amin MB, Lyles R, Johnstone PA, Marshall FF, Chung LW. Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis. Cancer Res. 2008 Dec 1;68(23):9996-10003 PUBMED
Bin Hafeez B, Adhami VM, Asim M, Siddiqui IA, Bhat KM, Zhong W, Saleem M, Din M, Setaluri V, Mukhtar H. Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator. Clin Cancer Res. 2009 Jan 15;15(2):452-9. PUBMED
Hypoxia Signaling
Kubo M, Li TS, Suzuki R, Shirasawa B, Morikage N, Ohshima M, Qin SL, Hamano K Hypoxic preconditioning increases survival and angiogenic potency of peripheral blood mononuclear cells via oxidative stress resistance Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H590-5. Epub 2007 Dec 21  PUBMED
Hematopoesis
Laricchia-Robbio L, Premanand K, Rinaldi CR, Nucifora G. EVI1 Impairs Myelopoiesis by Deregulation of PU.1 Function. Cancer Res. 2009 Feb 10. [Epub ahead of print] PUBMED
Inflammatory Cytokines & Receptors
Aravalli RN, Hu S, Rowen TN, Palmquist JM, Lokensgard JR. Cutting edge: TLR2-mediated proinflammatory cytokine and chemokine production by microglial cells in response to herpes simplex virus J Immunol. 2005 Oct 1;175(7):4189-93. PUBMED
 
Ganta CK, Helwig BG, Blecha F, Ganta RR, Cober R, Parimi S, Musch TI, Fels RJ, Kenney MJ. "Hypothermia-enhanced Splenic Cytokine Gene Expression is Independent of the Sympathetic Nervous System. Am J Physiol Regul Integr Comp Physiol. 2006 Feb 9; [Epub ahead of print] PUBMED
 
Lee JH, Kim M, Im YS, Choi W, Byeon SH, Lee HK NFAT5 induction and its role in hyperosmolar stressed human limbal epithelial cells. Invest Ophthalmol Vis Sci. 2008 May;49(5):1827-35  PUBMED
Rupprecht TA, Angele B, Klein M, Heesemann J, Pfister HW, Botto M, Koedel U. Complement C1q and C3 are critical for the innate immune response to Streptococcus pneumoniae in the central nervous system. J Immunol. 2007 Feb 1;178(3):1861-9. PUBMED
Vera PL, Wang X, Meyer-Siegler KL. Upregulation of macrophage migration inhibitory factor (MIF) and CD74, receptor for MIF, in rat bladder during persistent cyclophosphamide-induced inflammation Exp Biol Med (Maywood). 2008 May;233(5):620-6. Epub 2008 Mar 28.  PUBMED
Nacu N, Luzina IG, Highsmith K, Lockatell V, Pochetuhen K, Cooper ZA, Gillmeister MP, Todd NW, Atamas SP Macrophages produce TGF-beta-induced (beta-ig-h3) following ingestion of apoptotic cells and regulate MMP14 levels and collagen turnover in fibroblasts J Immunol. 2008 Apr 1;180(7):5036-44  PUBMED
Bald? A, Gomes AV, Ping P, Edwards PA. Loss of ABCG1 Results in Chronic Pulmonary Inflammation. J Immunol. 2008 Mar 1;180(5):3560-8  PUBMED
Tran TA, McCoy MK, Sporn MB, Tansey MG. The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection. J Neuroinflammation. 2008 May 12;5:14. PUBMED
Buvanendran A, Mitchell K, Kroin JS, Iadarola MJ. Cytokine gene expression after total hip arthroplasty: surgical site versus Anesth Analg. 2009 Sep;109(3):959-64.PUBMED
Inflammatory Response and Autoimmunity
Vyas K, Chaudhuri S, Leaman DW, Komar AA, Musiyenko A, Barik S, Mazumder B. Genome-wide polysome profiling reveals an inflammation-responsive posttranscriptional operon in gamma interferon-activated monocytes. Mol Cell Biol. 2009 Jan;29(2):458-70. Epub 2008 Nov 10 PUBMED
Li Z, Liu B, Maminishkis A, Mahesh SP, Yeh S, Lew J, Lim WK, Sen HN, Clarke G, Buggage R, Miller SS, Nussenblatt RB. Gene expression profiling in autoimmune noninfectious uveitis disease. J Immunol. 2008 Oct 1;181(7):5147-57. PUBMED
Abolhassani M, Aloulou N, Chaumette MT, Aparicio T, Martin-Garcia N, Mansour H, Le Gouvello S, Delchier JC, Sobhani I. Leptin receptor-related immune response in colorectal tumors: the role of colonocytes and interleukin-8. Cancer Res. 2008 Nov 15;68(22):9423-32 PUBMED
Insulin Signaling
Fulzele K, DiGirolamo DJ, Liu Z, Xu J, Messina JL, Clemens TL. Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action. J Biol Chem. 2007 Aug 31;282(35):25649-58. Epub 2007 Jun 6. PUBMED
Vyas K, Chaudhuri S, Leaman DW, Komar AA, Musiyenko A, Barik S, Mazumder B. Genome-wide polysome profiling reveals an inflammation-responsive posttranscriptional operon in gamma interferon-activated monocytes. Mol Cell Biol. 2009 Jan;29(2):458-70. Epub 2008 Nov 10 PUBMED
Lennon R, Pons D, Sabin MA, Wei C, Shield JP, Coward RJ, Tavare JM, Mathieson PW, Saleem MA, Welsh GI. Saturated fatty acids induce insulin resistance in human podocytes: implications Nephrol Dial Transplant. 2009 Nov;24(11):3288-96. Epub 2009 Jun 25.PUBMED
JAK / STAT Signaling
Liby K, Voong N, Williams CR, Risingsong R, Royce DB, Honda T, Gribble GW, Sporn MB, Letterio JJ. The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells. Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4288-93. PUBMED
 
Vargas-Inchaustegui DA, Xin L, Soong L Leishmania braziliensis Infection Induces Dendritic Cell Activation, ISG15 Transcription, and the Generation of Protective Immune Responses. J Immunol. 2008 Jun 1;180(11):7537-45.  PUBMED
Torroella-Kouri M, Silvera R, Rodriguez D, Caso R, Shatry A, Opiela S, Ilkovitch D, Schwendener RA, Iragavarapu-Charyulu V, Cardentey Y, Strbo N, Lopez DM. Identification of a subpopulation of macrophages in mammary tumor-bearing mice Cancer Res. 2009 Jun 1;69(11):4800-9. Epub 2009 May 19.PUBMED
Neurogenesis & Neural Stem Cells
Greco SJ, Rameshwar P Enhancing effect of IL-1alpha on neurogenesis from adult human mesenchymal stem cells: implication for inflammatory mediators in regenerative medicine. J Immunol. 2007 Sep 1;179(5):3342-50 PUBMED
 
NFκB Signaling
de Oliveira-Marques V, Cyrne L, Marinho HS, Antunes F A Quantitative Study of NF-{kappa}B Activation by H2O2: Relevance in Inflammation and Synergy with TNF-{alpha}. J Immunol. 2007 Mar 15;178(6):3893-902. PUBMED
Emdad L, Sarkar D, Su ZZ, Randolph A, Boukerche H, Valerie K, Fisher PB Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis Cancer Res. 2006 Feb 1;66(3):1509-16. PUBMED
Liu B, Li Z, Mahesh SP, Pantanelli S, Hwang FS, Siu WO, Nussenblatt RB. Glucocorticoid-induced Tumor Necrosis Factor Receptor Negatively Regulates Activation of Human Primary Natural Killer (NK) Cells by Blocking Proliferative Signals and Increasing NK Cell Apoptosis. J Biol Chem. 2008 Mar 28;283(13):8202-10. Epub 2008 Jan 29  PUBMED
Catalano A, Lazzarini R, Di Nuzzo S, Orciari S, Procopio A. The Plexin-A1 Receptor Activates Vascular Endothelial Growth Factor-Receptor 2 and Nuclear Factor-{kappa}B to Mediate Survival and Anchorage-Independent Growth of Malignant Mesothelioma Cells. Cancer Res. 2009 Jan 27. [Epub ahead of print] PUBMED
Farhana L, Dawson MI, Xu L, Fontana JA. SHP and Sin3A expression are essential for adamantyl-substituted retinoid-related Mol Cancer Ther. 2009 Jun;8(6):1625-35. Epub 2009 Jun 9.PUBMED
Notch Signaling
Wang L, O'Leary H, Fortney J, Gibson LF. Ph+/VE-cadherin+ identifies a stem cell like population of acute lymphoblastic leukemia sustained by bone marrow niche cells. Blood. 2007 Nov 1;110(9):3334-44. Epub 2007 Jul 16. PUBMED
Singh M, Mukherjee P, Narayanasamy K, Arora R, Sen SD, Gupta S, Natarajan K, Malhotra P. Proteome analysis of Plasmodium falciparum extracellular secretory antigens at Mol Cell Proteomics. 2009 Sep;8(9):2102-18. Epub 2009 Jun 3.PUBMED
Osteogenesis
Surmann-Schmitt C, Dietz U, Kireva T, Adam N, Park J, Tagariello A, Onnerfjord P, Heineg?d D, Schl?zer-Schrehardt U, Deutzmann R, von der Mark K, Stock M. Ucma, a Novel Secreted Cartilage-specific Protein with Implications in Osteogenesis J Biol Chem. 2008 Mar 14;283(11):7082-93. Epub 2007 Dec 21  PUBMED
Galdones E, Hales BF. Retinoic acid receptor gamma-induced misregulation of chondrogenesis in the murine limb bud in vitro. Toxicol Sci. 2008 Nov;106(1):223-32. Epub 2008 Aug 14 PUBMED
p53 Signaling Pathway
Ishii H, Du H, Zhang Z, Henderson A, Sen R, Pazin MJ. Mi2beta shows chromatin enzyme specificity by erasing a DNase I-hypersensitive J Biol Chem. 2009 Mar 20;284(12):7533-41. Epub 2009 Jan 21.PUBMED
Prostate Cancer
Bianchini A, Loiarro M, Bielli P, Bus?R, Paronetto MP, Loreni F, Geremia R, Sette C Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells. Carcinogenesis. 2008 Dec;29(12):2279-88. Epub 2008 Sep 22 PUBMED
Signal Transductioin in Cancer
Zeng H, Wu M, Botnen JH. Methylselenol, a selenium metabolite, induces cell cycle arrest in G1 phase and J Nutr. 2009 Sep;139(9):1613-8. Epub 2009 Jul 22.PUBMED
Signal Transduction PathwayFinder
Kapoor R, Sheng JJ. Transfection of human prostate cancer CA-HPV-10 cells with cytosolic sulfotransferase SULT1E1 affects estrogen signaling and gene transcription. Drug Metab Dispos. 2007 Nov 5; [Epub ahead of print] PUBMED
Mirotsou M, Zhang Z, Deb A, Zhang L, Gnecchi M, Noiseux N, Mu H, Pachori A, Dzau V. Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1643-8. Epub 2007 Jan 24. PUBMED
 
Shamhart PE, Luther DJ, Hodson BR, Koshy JC, Ohanyan V, Meszaros JG. Impact of type 1 diabetes on cardiac fibroblast activation: enhanced cell cycle Am J Physiol Endocrinol Metab. 2009 Aug 25.PUBMED
Liu XS, Chopp M, Zhang RL, Hozeska-Solgot A, Gregg SC, Buller B, Lu M, Zhang ZG. Angiopoietin 2 mediates the differentiation and migration of neural progenitor J Biol Chem. 2009 Aug 21;284(34):22680-9. Epub 2009 Jun 24.PUBMED
Stem Cell
Wang L, O'Leary H, Fortney J, Gibson LF. Ph+/VE-cadherin+ identifies a stem cell like population of acute lymphoblastic leukemia sustained by bone marrow niche cells. Blood. 2007 Nov 1;110(9):3334-44. Epub 2007 Jul 16. PUBMED
 
TGFβ / BMP Signaling
Kato M, Zhang J, Wang M, Lanting L, Yuan H, Rossi JJ, Natarajan R. MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3432-7. Epub 2007 Feb 20. PUBMED
Yamashita M, Otsuka F, Mukai T, Otani H, Inagaki K, Miyoshi T, Goto J, Yamamura M, Makino H Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway. J Endocrinol. 2008 Mar;196(3):601-13  PUBMED
Takahashi M, Otsuka F, Miyoshi T, Otani H, Goto J, Yamashita M, Ogura T, Makino H, Doihara H. Bone morphogenetic protein 6 (BMP6) and BMP7 inhibit estrogen-induced proliferation of breast cancer cells by suppressing p38 mitogen-activated protein kinase activation. J Endocrinol. 2008 Dec;199(3):445-55. Epub 2008 Sep 9. PUBMED
Th1 / Th2
Lee JK, McCoy MK, Harms AS, Ruhn KA, Gold SJ, Tansey MG. Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory response. J Neurosci. 2008 Aug 20;28(34):8517-28. PUBMED
Toll-Like Receptor Signaling Pathway
Sharma A, Maheshwari RK. Oligonucleotide array analysis of Toll-like receptors and associated signalling J Gen Virol. 2009 Aug;90(Pt 8):1836-47. Epub 2009 Apr 15.PUBMED
Toxicology & Drug Resistance
Zhang L, Hannay JA, Liu J, Das P, Zhan M, Nguyen T, Hicklin DJ, Yu D, Pollock RE, Lev D. Vascular endothelial growth factor overexpression by soft tissue sarcoma cells: implications for tumor growth, metastasis, and chemoresistance. Cancer Res. 2006 Sep 1;66(17):8770-8. PUBMED
L鰊n-Stensrud J, Landin MA, Benneche T, Petersen FC, Scheie AA Furanones, potential agents for preventing Staphylococcus epidermidis biofilm infections? J Antimicrob Chemother. 2009 Feb;63(2):309-16. Epub 2008 Dec 20 PUBMED
Tumor Metastasis
Li H, Fan X, Kovi RC, Jo Y, Moquin B, Konz R, Stoicov C, Kurt-Jones E, Grossman SR, Lyle S, Rogers AB, Montrose M, Houghton J. Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice. Cancer Res. 2007 Nov 15;67(22):10889-98. PUBMED
Satpathy M, Shao M, Emerson R, Donner DB, Matei D. Tissue transglutaminase regulates matrix metalloproteinase-2 in ovarian cancer by J Biol Chem. 2009 Jun 5;284(23):15390-9. Epub 2009 Mar 26.PUBMED
WNT Signaling
Baksh D, Yao R, Tuan RS. Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. Stem Cells. 2007 Jun;25(6):1384-92. Epub 2007 Mar 1. PUBMED
Giuliani N, Morandi F, Tagliaferri S, Lazzaretti M, Donofrio G, Bonomini S, Sala R, Mangoni M, Rizzoli V. Production of Wnt inhibitors by myeloma cells: potential effects on canonical Wnt pathway in the bone microenvironment. Cancer Res. 2007 Aug 15;67(16):7665-74 PUBMED
Liu Z, Habener JF. Glucagon-like Peptide-1 Activation of TCF7L2-dependent Wnt Signaling Enhances Pancreatic Beta Cell Proliferation. J Biol Chem. 2008 Mar 28;283(13):8723-35. Epub 2008 Jan 23  PUBMED
Ortega P, Mor? A, de Juan C, Fr?s C, Hern?dez S, L?ez-Asenjo JA, S?chez-Pernaute A, Torres A, Iniesta P, Benito M. Differential Wnt pathway gene expression and E-cadherin truncation in sporadic colorectal cancers with and without microsatellite instability. Clin Cancer Res. 2008 Feb 15;14(4):995-1001  PUBMED
Wang L, O'Leary H, Fortney J, Gibson LF. Ph+/VE-cadherin+ identifies a stem cell like population of acute lymphoblastic leukemia sustained by bone marrow niche cells. Blood. 2007 Nov 1;110(9):3334-44. Epub 2007 Jul 16 PUBMED
Groen RW, Oud ME, Schilder-Tol EJ, Overdijk MB, ten Berge D, Nusse R, Spaargaren M, Pals ST. Illegitimate WNT pathway activation by beta-catenin mutation or autocrine stimulation in T-cell malignancies. Cancer Res. 2008 Sep 1;68(17):6969-77. PUBMED
Shah GV, Muralidharan A, Gokulgandhi M, Soan K, Thomas S. Cadherin switching and activation of beta-catenin signaling underlie proinvasive actions of calcitonin-calcitonin receptor axis in prostate cancer. J Biol Chem. 2009 Jan 9;284(2):1018-30. Epub 2008 Nov 9. PUBMED

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CASE Kits

 
AKT
Cantiani L, Manara MC, Zucchini C, De Sanctis P, Zuntini M, Valvassori L, Serra M, Olivero M, Di Renzo MF, Colombo MP, Picci P, Scotlandi K. Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling. Cancer Res. 2007 Aug 15;67(16):7675-85. PUBMED
Choudhari SR, Khan MA, Harris G, Picker D, Jacob GS, Block T, Shailubhai K. Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod. Mol Cancer Ther. 2007 Jan;6(1):112-21. PUBMED
Koshkin V, Dai FF, Robson-Doucette CA, Chan CB, Wheeler MB Limited Mitochondrial Permeabilization Is an Early Manifestation of Palmitate-induced Lipotoxicity in Pancreatic {beta}-Cells J Biol Chem. 2008 Mar 21;283(12):7936-48. Epub 2007 Dec 26  PUBMED
Singla DK, Singla RD, McDonald DE. Factors Released from Embryonic Stem Cells inhibit Apoptosis in H9c2 cells through P1-3kinase/Akt but not ERK pathway. Am J Physiol Heart Circ Physiol. 2008 Jun 13. [Epub ahead of print]  PUBMED
Xia S, Forman LW, Faller DV. Protein kinase C delta is required for survival of cells expressing activated p21RAS. J Biol Chem. 2007 May 4;282(18):13199-210. Epub 2007 Mar 8. PUBMED
Kurtagic E, Jedrychowski MP, Nugent MA. Neutrophil Elastase Cleaves VEGF to Generate a VEGF Fragment with Altered Activity. Am J Physiol Lung Cell Mol Physiol. 2009 Jan 9. [Epub ahead of print] PUBMED
ERBB2
Park JM, Terabe M, Steel JC, Forni G, Sakai Y, Morris JC, Berzofsky JA. Therapy of advanced established murine breast cancer with a recombinant adenoviral ErbB-2/neu vaccine Cancer Res. 2008 Mar 15;68(6):1979-87  PUBMED
ERK
Kidd M, Modlin IM, Eick GN, Camp RL, Mane SM Role of CCN2/CTGF in the proliferation of Mastomys enterochromaffin-like cells and gastric carcinoid development. Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G191-200. Epub 2006 Aug 31. PUBMED
Kidd M, Modlin IM, Gustafsson BI, Drozdov I, Hauso O, Pfragner R. The luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants and olfactants. Am J Physiol Gastrointest Liver Physiol. 2008 Jun 12. [Epub ahead of print]  PUBMED
Lirk P, Haller I, Colvin HP, Lang L, Tomaselli B, Klimaschewski L, Gerner P In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity Anesth Analg. 2008 May;106(5):1456-64, table of contents  PUBMED
Perl M, Chung CS, Perl U, Lomas-Neira J, de Paepe M, Cioffi WG, Ayala A Fas-induced pulmonary apoptosis and inflammation during indirect acute lung injury. Am J Respir Crit Care Med. 2007 Sep 15;176(6):591-601. Epub 2007 Jun 28 PUBMED
Singla DK, Singla RD, McDonald DE. Factors Released from Embryonic Stem Cells inhibit Apoptosis in H9c2 cells through P1-3kinase/Akt but not ERK pathway. Am J Physiol Heart Circ Physiol. 2008 Jun 13. [Epub ahead of print]  PUBMED
Yan Z, Zou H, Tian F, Grandis JR, Mixson AJ, Lu PY, Li LY. Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth. Mol Cancer Ther. 2008 Jun 4. [Epub ahead of print]  PUBMED
Profita M, Bonanno A, Siena L, Bruno A, Ferraro M, Montalbano AM, Albano GD, Riccobono L, Casarosa P, Pieper MP, Gjomarkaj M. Smoke, Choline-Acetyl-Transferase, Muscarinic Receptors and fibroblast proliferation in COPD. J Pharmacol Exp Ther. 2009 Feb 3. [Epub ahead of print] PUBMED
Zou H, Thomas SM, Yan ZW, Grandis JR, Vogt A, Li LY Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells. FASEB J. 2009 Feb;23(2):425-32. Epub 2008 Oct 2. PUBMED
Uddin MN, Horvat D, Childs EW, Puschett JB. Marinobufagenin causes endothelial cell monolayer hyperpermeability by altering Am J Physiol Regul Integr Comp Physiol. 2009 Jun;296(6):R1726-34. Epub 2009 AprPUBMED
Kemp EH, Gavalas NG, Krohn KJ, Brown EM, Watson PF, Weetman AP. Activating autoantibodies against the calcium-sensing receptor detected in two patients with autoimmune polyendocrine syndrome type 1. J Clin Endocrinol Metab. 2009 Dec;94(12):4749-56. Epub 2009 Oct 16.PUBMED
Matera G, Muto V, Vinci M, Zicca E, Abdollahi-Roodsaz S, van de Veerdonk FL, Kullberg BJ, Liberto MC, van der Meer JW, Focŕ A, Netea MG, Joosten LA. Receptor recognition of and immune intracellular pathways for Veillonella parvula lipopolysaccharide. Clin Vaccine Immunol. 2009 Dec;16(12):1804-9. Epub 2009 Oct 14.PUBMED
IkBa
Kanda N, Watanabe S. Prolactin enhances interferon-gamma-induced production of CXC ligand 9 (CXCL9), CXCL10, and CXCL11 in human keratinocytes. Endocrinology. 2007 May;148(5):2317-25. Epub 2007 Jan 25. PUBMED
Kanda N, Watanabe S. Histamine enhances the production of human {beta}-defensin-2 in human keratinocytes Am J Physiol Cell Physiol. 2007 Oct 10; [Epub ahead of print] PUBMED
Guill閚 MI, Meg韆s J, Cl閞igues V, Gomar F, Alcaraz MJ. The CO-releasing molecule CORM-2 is a novel regulator of the inflammatory process in osteoarthritic chondrocytes. Rheumatology (Oxford). 2008 Sep;47(9):1323-8. Epub 2008 Jul 11. PUBMED
JNK
Holley SL, Fryer AA, Haycock JW, Grubb SE, Strange RC, Hoban PR. Differential effects of glutathione S-transferase pi (GSTP1) haplotypes on cell proliferation and apoptosis. Carcinogenesis. 2007 Nov;28(11):2268-73. Epub 2007 Jun 8. PUBMED
Lirk P, Haller I, Colvin HP, Lang L, Tomaselli B, Klimaschewski L, Gerner P In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity Anesth Analg. 2008 May;106(5):1456-64, table of contents  PUBMED
Uddin MN, Horvat D, Glaser SS, Mitchell BM, Puschett JB. Examination of the cellular mechanisms by which marinobufagenin inhibits cytotrophoblast function. J Biol Chem. 2008 Jun 27;283(26):17946-53. Epub 2008 Apr 23.  PUBMED
Jun
Suga H, Eto H, Shigeura T, Inoue K, Aoi N, Kato H, Nishimura S, Manabe I, Gonda K, Yoshimura K. IFATS Series: FGF-2-induced HGF Secretion By Adipose-Derived Stromal Cells Inhibits Post-Injury Fibrogenesis Through A JNK-Dependent Mechanism. Stem Cells. 2008 Sep 4. [Epub ahead of print] PUBMED
NFkB p65
Kanda N, Watanabe S. Prolactin enhances interferon-gamma-induced production of CXC ligand 9 (CXCL9), CXCL10, and CXCL11 in human keratinocytes. Endocrinology. 2007 May;148(5):2317-25. Epub 2007 Jan 25. PUBMED
Naderi A, Teschendorff AE, Beigel J, Cariati M, Ellis IO, Brenton JD, Caldas C. BEX2 is overexpressed in a subset of primary breast cancers and mediates nerve growth factor/nuclear factor-kappaB inhibition of apoptosis in breast cancer cell lines. Cancer Res. 2007 Jul 15;67(14):6725-36. PUBMED
Soliman S, Aronson WJ, Barnard RJ. Analyzing Serum-Stimulated Prostate Cancer Cell Lines After Low-Fat, High-Fiber Evid Based Complement Alternat Med. 2009 Apr 17.PUBMED
Loizou S, Paraschos S, Mitakou S, Chrousos GP, Lekakis I, Moutsatsou P. Chios mastic gum extract and isolated phytosterol tirucallol exhibit Exp Biol Med (Maywood). 2009 May;234(5):553-61. Epub 2009 Feb 20.PUBMED
p38
Kanda N, Watanabe S. Prolactin enhances interferon-gamma-induced production of CXC ligand 9 (CXCL9), CXCL10, and CXCL11 in human keratinocytes. Endocrinology. 2007 May;148(5):2317-25. Epub 2007 Jan 25. PUBMED
Uddin MN, Horvat D, Glaser SS, Mitchell BM, Puschett JB. Examination of the cellular mechanisms by which marinobufagenin inhibits cytotrophoblast function. J Biol Chem. 2008 Jun 27;283(26):17946-53. Epub 2008 Apr 23.  PUBMED
SRC
Cantiani L, Manara MC, Zucchini C, De Sanctis P, Zuntini M, Valvassori L, Serra M, Olivero M, Di Renzo MF, Colombo MP, Picci P, Scotlandi K. Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling. Cancer Res. 2007 Aug 15;67(16):7675-85. PUBMED
 
Gong P, Angelini DJ, Yang S, Xia G, Cross AS, Mann D, Bannerman DD, Vogel SN, Goldblum SE TLR4 Signaling Is Coupled to SRC Family Kinase Activation, Tyrosine Phosphorylation of Zonula Adherens Proteins, and Opening of the Paracellular Pathway in Human Lung Microvascular Endothelia J Biol Chem. 2008 May 9;283(19):13437-49. Epub 2008 Mar 7  PUBMED
Uddin MN, Horvat D, Glaser SS, Mitchell BM, Puschett JB. Examination of the cellular mechanisms by which marinobufagenin inhibits cytotrophoblast function. J Biol Chem. 2008 Jun 27;283(26):17946-53. Epub 2008 Apr 23.  PUBMED
STAT3
Choudhari SR, Khan MA, Harris G, Picker D, Jacob GS, Block T, Shailubhai K. Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod. Mol Cancer Ther. 2007 Jan;6(1):112-21. PUBMED
Fan W, Yanase T, Nishi Y, Chiba S, Okabe T, Nomura M, Yoshimatsu H, Kato S, Takayanagi R, Nawata H. FUNCTIONAL POTENTIATION OF LEPTIN-STAT3 SIGNALING BY THE ANDROGEN RECEPTOR. Endocrinology. 2008 Aug 14. [Epub ahead of print] PUBMED
Beales IL, Ogunwobi OO. Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and J Mol Endocrinol. 2009 Apr;42(4):305-18. Epub 2009 Jan 19.PUBMED

CASE Inhibitors

 
ERK
Kroening PR, Barnes TW, Pease L, Limper A, Kita H, Vassallo R. Cigarette Smoke-Induced Oxidative Stress Suppresses Generation of Dendritic Cell IL-12 and IL-23 through ERK-Dependent Pathways. J Immunol. 2008 Jul 15;181(2):1536-47.  PUBMED
JNK
Addison WN, Azari F, S?ensen ES, Kaartinen MT, McKee MD. Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity. J Biol Chem. 2007 May 25;282(21):15872-83. Epub 2007 Mar 23.  PUBMED
p38
Kroening PR, Barnes TW, Pease L, Limper A, Kita H, Vassallo R. Cigarette Smoke-Induced Oxidative Stress Suppresses Generation of Dendritic Cell IL-12 and IL-23 through ERK-Dependent Pathways. J Immunol. 2008 Jul 15;181(2):1536-47.  PUBMED

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Service

 
Hamidi SA, Prabhakar S, Said SI. Enhancement of pulmonary vascular remodelling and inflammatory genes with VIP gene deletion. Eur Respir J. 2008 Jan;31(1):135-9. PUBMED
Melnick M, Mocarski ES, Abichaker G, Huang J, Jaskoll T. Cytomegalovirus-induced embryopathology: mouse submandibular salivary gland epithelial-mesenchymal ontogeny as a model. BMC Dev Biol. 2006 Sep 7;6:42.  PUBMED
Piechocki MP, Yoo GH, Dibbley SK, Lonardo F. Breast cancer expressing the activated HER2/neu is sensitive to gefitinib in vitro and in vivo and acquires resistance through a novel point mutation in the HER2/neu. Cancer Res. 2007 Jul 15;67(14):6825-43  PUBMED
Pinkerton MN, Wescott DC, Gaffey BJ, Beggs KT, Milne TJ, Meikle MC. Cultured human periodontal ligament cells constitutively express multiple osteotropic cytokines and growth factors, several of which are responsive to mechanical deformation. J Periodontal Res. 2007 Dec 17 [Epub ahead of print]  PUBMED
Raeder S, Utheim TP, Utheim OA, Nicolaissen B, Roald B, Cai Y, Haug K, Kvalheim A, Messelt EB, Drolsum L, Reed JC, Lyberg T. Effects of organ culture and Optisol-GS storage on structural integrity, phenotypes, and apoptosis in cultured corneal epithelium. Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5484-93.  PUBMED
Tilton JC, Manion MM, Luskin MR, Johnson AJ, Patamawenu AA, Hallahan CW, Cogliano-Shutta NA, Mican JM, Davey RT Jr, Kottilil S, Lifson JD, Metcalf JA, Lempicki RA, Connors M. Human immunodeficiency virus viremia induces plasmacytoid dendritic cell activation in vivo and diminished alpha interferon production in vitro. J Virol. 2008 Apr;82(8):3997-4006. Epub 2008 Feb 6  PUBMED
Wescott DC, Pinkerton MN, Gaffey BJ, Beggs KT, Milne TJ, Meikle MC. Osteogenic gene expression by human periodontal ligament cells under cyclic tension. J Dent Res. 2007 Dec;86(12):1212-6.  PUBMED
Zhang Y, Woodruff M, Zhang Y, Miao J, Hanley G, Stuart C, Zeng X, Prabhakar S, Moorman J, Zhao B, Yin D. Toll-like receptor 4 mediates chronic restraint stress-induced immune suppression. J Neuroimmunol. 2008 Jan 11 [Epub ahead of print]  PUBMED
Desai SP, Kojima K, Vacanti CA, Kodama S. Lidocaine inhibits NIH-3T3 cell multiplication by increasing the expression of cyclin-dependent kinase inhibitor 1A (p21). Anesth Analg. 2008 Nov;107(5):1592-7 PUBMED
Sinha P, Okoro C, Foell D, Freeze HH, Ostrand-Rosenberg S, Srikrishna G. Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells. J Immunol. 2008 Oct 1;181(7):4666-75. PUBMED
Leatherbury, L, Yu, Q, Chatterjee, B, Walker, DL, Yu, Z., Tian, X., and Lo, CW A novel mouse model of X-linked cardiac hypertrophy. Am J Physiol Heart Circ Physiol 2008 April 18; 294: H2701-H2711 PUBMED
Sinha S, Subramanian S, Proctor TM, Kaler LJ, Grafe M, Dahan R, Huan J, Vandenbark AA, Burrows GG, Offner H. A promising therapeutic approach for multiple sclerosis: recombinant T-cell receptor ligands modulate experimental autoimmune encephalomyelitis by reducing interleukin-17 production and inhibiting migration of encephalitogenic cells into the CNS.J Neurosci. 27(46):12531-9. PUBMED
Bernstein, M., Chakraborty, M., Wansley, E., Guo, Z., D., Franzusof, A., Mostbock, S., Sabzevari, H., Schlom, J., and Hodge, J.W. Recombinant Saccharomyces cerevisiae (yeast-CEA) as a potent activator of murine dendritic cells. Vaccine. 26:509-521. PUBMED
Remondo et. al. Human dendritic cell maturation and activation by a heat-killed recombinant yeast (Saccharomyces cerevisiae) vector encoding carcinoembryonic antigen. Vaccine. 2009 Feb 11; 27(7):987-94. PUBMED
Yu J, Kindy MS, Gattoni-Celli S. Semi-Allogeneic Vaccine for T-Cell Lymphoma. J Translational Medicine, 5:39 PUBMED
Yu J, Kindy MS, Gattoni-Celli S. Semi-Allogeneic Vaccines and Tumor-Induced Immune Tolerance. J Translational Medicine, 7:3 PUBMED
Secchiero, P., Corallini, F., di Iasio, MG., Gonelli, A., Barbarotto, E., and Zauli, G. TRAIL counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expression and release. Blood, 2005 May;105: 3413 - 3419. PUBMED
Luo, Y., Schwartz, C., Shin, S., Zeng, X., Chen, N., Wang, Y., Yu, X., and Rao, MS. A Focused Microarray to Assess Dopaminergic and Glial Cell Differentiation from Fetal Tissue or Embryonic Stem Cells. Stem Cells, 2006 Apr; 24: 865 - 875. PUBMED
Jaskoll, T., Abichaker, G., Sedghizadeh, PP., Bringas Jr, P., and Melnick, M. Cytomegalovirus induces abnormal chondrogenesis and osteogenesis during embryonic mandibular development. BMC Dev Biol, 2007 Nov; 8: 33. PUBMED
Propst JT, Fann SA, Franchini JL, Hansen KJ, Yost MJ, Lessner SM, Terracio L. Focused in vivo genetic analysis of implanted engineered myofascial constructs. J Invest Surg. 2008 Jan; 22(1):35-45. PUBMED
di Iasio MG, Secchiero P, Tiribelli M, Zauli G. Reduced expression of cell cycle-associated genes in B lymphocytes purified from the peripheral blood of early-stage B chronic lymphocytic leukaemia patients. Br J Haematol. 2009 Feb 3. [Epub ahead of print] PUBMED
Secchiero P, Melloni E, di Iasio MG, Tiribelli M, Rimondi E, Corallini F, Gattei V, Zauli G. Nutlin-3 upregulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feed-back anti-apoptotic mechanism. Blood. 2009 Feb 3. [Epub ahead of print] PUBMED
Secchiero P, Corallini F, Rimondi E, Chiaruttini C, di Iasio MG, Rustighi A, Del Sal G, Zauli G. Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells. Blood. 2008 Feb 1;111(3):1287-94. Epub 2007 Nov 13. PUBMED
Secchiero P, Zerbinati C, di Iasio MG, Melloni E, Tiribelli M, Grill V, Zauli G. Synergistic cytotoxic activity of recombinant TRAIL plus the non-genotoxic activator of the p53 pathway nutlin-3 in acute myeloid leukemia cells. Curr Drug Metab.2007 May;8(4):395-403. PUBMED
Secchiero P, di Iasio MG, Gonelli A, Barbarotto E, Melloni E, Tiribelli M, Chiaruttini C, Zauli G. Differential gene expression induction by TRAIL in B chronic lymphocytic leukemia (B-CLL) cells showing high versus low levels of Zap-70. J Cell Physiol. 2007 Oct;213(1):229-36. PUBMED
Secchiero P, Barbarotto E, Tiribelli M, Zerbinati C, di Iasio MG, Gonelli A, Cavazzini F, Campioni D, Fanin R, Cuneo A, Zauli G. Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL). Blood. 2006 May 15;107(10):4122-9. PUBMED
Secchiero P, Corallini F, Barbarotto E, Melloni E, di Iasio MG, Tiribelli M, Zauli G. Role of the RANKL/RANK system in the induction of interleukin-8 (IL-8) in B chronic lymphocytic leukemia (B-CLL) cells. J Cell Physiol. 2006 Apr;207(1):158-64. PUBMED
Secchiero P, Corallini F, di Iasio MG, Gonelli A, Barbarotto E, Zauli G. TRAIL counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expression and release. Blood. 2005 May 1;105(9):3413-9. PUBMED
Pucci S et al. Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression. Cell Cycle 2009, Feb 1;8(3):473-81. PUBMED
Qadura M, Waters B, Burnett E, Chegeni R, Bradshaw S, Hough C, Othman M, Lillicrap D. Recombinant and plasma-derived factor VIII products induce distinct splenic Blood. 2009 Jul 23;114(4):871-80. Epub 2009 May 1.PUBMED
Bearzi C, Leri A, Lo Monaco F, Rota M, Gonzalez A, Hosoda T, Pepe M, Qanud K, Ojaimi C, Bardelli S, D'Amario D, D'Alessandro DA, Michler RE, Dimmeler S, Zeiher AM, Urbanek K, Hintze TH, Kajstura J, Anversa P. Identification of a coronary vascular progenitor cell in the human heart. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15885-90. Epub 2009 Aug 27.PUBMED

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EpiTect ChIP qPCR
Subbaramaiah K, Hudis C, Chang SH, Hla T, Dannenberg AJ. EP2 and EP4 Receptors Regulate Aromatase Expression in Human Adipocytes and Breast Cancer Cells: EVIDENCE OF A BRCA1 AND p300 EXCHANGE. J Biol Chem. 2008 Feb 8;283(6):3433-44. Epub 2007 Dec 14. PUBMED
Sampath D, Calin GA, Puduvalli VK, Gopisetty G, Taccioli C, Liu CG, Ewald B, Liu C, Keating MJ, Plunkett W. Specific activation of microRNA106b enables the p73 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase, Itch for degradation. Blood. 2008 Dec 18. [Epub ahead of print] PUBMED
Genua M, Pandini G, Sisci D, Castoria G, Maggiolini M, Vigneri R, Belfiore A. Role of cyclic AMP response element-binding protein in insulin-like growth factor-i receptor up-regulation by sex steroids in prostate cancer cells. Cancer Res. 2009 Sep 15;69(18):7270-7. Epub 2009 Sep 8. PUBMED
Nagai Y, Yonemitsu S, Erion DM, Iwasaki T, Stark R, Weismann D, Dong J, Zhang D, Jurczak MJ, L?ffler MG, Cresswell J, Yu XX, Murray SF, Bhanot S, Monia BP, Bogan JS, Samuel V, Shulman GI. The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance. Cell Metab. 2009 Mar;9(3):252-64. PUBMED
Gemenetzidis E, Bose A, Riaz AM, Chaplin T, Young BD, Ali M, Sugden D, Thurlow JK, Cheong SC, Teo SH, Wan H, Waseem A, Parkinson EK, Fortune F, Teh MT. FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation. PLoS One. 2009;4(3):e4849. Epub 2009 Mar 16. PUBMED
Tanimoto T, Hattori N, Senoo T, Furonaka M, Ishikawa N, Fujitaka K, Haruta Y, Yokoyama A, Igarashi K, Kohno N. Genetic ablation of the Bach1 gene reduces hyperoxic lung injury in mice: role of IL-6. Free Radic Biol Med. 2009 Apr 15;46(8):1119-26. Epub 2009 Jan 29. PUBMED
Montoya-Durango DE, Liu Y, Teneng I, Kalbfleisch T, Lacy ME, Steffen MC, Ramos KS. Epigenetic control of mammalian LINE-1 retrotransposon by retinoblastoma proteins. Mutat Res. 2009 Jun 1;665(1-2):20-8. Epub 2009 Mar 9 PUBMED
Calonje M, Sanchez R, Chen L, Sung ZR. EMBRYONIC FLOWER1 participates in polycomb group-mediated AG gene silencing in Arabidopsis. Plant Cell. 2008 Feb;20(2):277-91. Epub 2008 Feb 15. PUBMED
Lyakhov IG, Krishnamachari A, Schneider TD. Discovery of novel tumor suppressor p53 response elements using information theory. Nucleic Acids Res. 2008 Jun;36(11):3828-33. Epub 2008 May 21. PUBMED
Panchanathan R, Shen H, Bupp MG, Gould KA, Choubey D. Female and male sex hormones differentially regulate expression of Ifi202, an interferon-inducible lupus susceptibility gene within the Nba2 interval. J Immunol. 2009 Dec 1;183(11):7031-8. Epub 2009 Nov 4. PUBMED
Klunker S, Chong MM, Mantel PY, Palomares O, Bassin C, Ziegler M, Rückert B, Meiler F, Akdis M, Littman DR, Akdis CA. Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells. J Exp Med. 2009 Nov 23;206(12):2701-15. Epub 2009 Nov 16. PUBMED


ELISArray Kits
Guo X, Hiroko, Kitmura T, Taketo M, Oshima M. Stromal fibroblasts activated by tumor cells promote angiogenesis in mouse gastric cancer. J Biol Chem. 2008 July 11; 283(28): 19864-19871 PUBMED
Zhang L, Stanford M, Liu J, Barrett C, Jiang L, Barclay AN, McFadden G. Inhibition of macrophage activation by the myxoma virus M141 protein (vCD200). J Virol. 2009 Sep;83(18):9602-7. Epub 2009 Jul 1.PUBMED
Reynolds AD, Stone DK, Mosley RL, Gendelman HE. Nitrated {alpha}-synuclein-induced alterations in microglial immunity are J Immunol. 2009 Apr 1;182(7):4137-49.PUBMED
Schepetkin IA, Kirpotina LN, Jakiw L, Khlebnikov AI, Blaskovich CL, Jutila MA, Quinn MT. Immunomodulatory activity of oenothein B isolated from Epilobium angustifolium. J Immunol. 2009 Nov 15;183(10):6754-66. Epub 2009 Oct 21.PUBMED
Jacobsen ID, Brunke S, Seider K, Schwarzmüller T, Firon A, d'Enfert C, Kuchler K, Hube B. Candida glabrata persistence in mice does not depend on host immunosuppression and is unaffected by fungal amino acid auxotrophy Infect Immun.. [Epub ahead of print]PUBMED
Magen E, Feldman A, Cohen Z, Alon DB, Minz E, Chernyavsky A, Linov L, Mishal J, Schlezinger M, Sthoeger Z. Circulating endothelial progenitor cells, Th1/Th2/Th17-related cytokines, and endothelial dysfunction in resistant hypertension. Am J Med Sci. 2010 Feb;339(2):117-22.PUBMED
Erbel C, Chen L, Bea F, Wangler S, Celik S, Lasitschka F, Wang Y, Böckler D, Katus HA, Dengler TJ. Inhibition of IL-17A attenuates atherosclerotic lesion development in apoE-deficient mice. J Immunol. 2009 Dec 15;183(12):8167-75.PUBMED
Tang Y, Desierto MJ, Chen J, Young NS. The role of the Th1 transcription factor T-bet in a mouse model of immune-mediated bone-marrow failure. Blood. 2010 Jan 21;115(3):541-8. Epub 2009 Nov 10.PUBMED
Deng J, Younge BR, Olshen RA, Goronzy JJ, Weyand CM. Th17 and Th1 T-cell responses in giant cell arteritis. Circulation. 2010 Feb 23;121(7):906-15. Epub 2010 Feb 8.PUBMED
Reynolds AD, Stone DK, Hutter JA, Benner EJ, Mosley RL, Gendelman HE. Regulatory T cells attenuate th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease. J Immunol. 2010 Mar 1;184(5):2261-71. Epub 2010 Jan 29.PUBMED
Dubrac S, Elentner A, Ebner S, Horejs-Hoeck J, Schmuth M. Modulation of T lymphocyte function by the pregnane X receptor. J Immunol. 2010 Mar 15;184(6):2949-57. Epub 2010 Feb 19.PUBMED


Cignal™ Reporter Assay System
Greer, R. M. et al.. SMAC Mimetic (JP1201) Sensitizes Non-Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α-Independent Manner. Cancer Res., 2011. PUBMED
Campeau, P.M., Rafei, M., Boivin, M.-N., Sun, Y., Grabowski, G.A., and Galipeau, J. Characterization of Gaucher disease bone marrow mesenchymal stromal cells reveals an altered inflammatory secretome. Blood, 2009 PUBMED
Elyakim, E. et al.. hsa-miR-191 Is a Candidate Oncogene Target for Hepatocellular Carcinoma Therapy. Cancer Res., 2010. PUBMED
Zughaier, S.M.. Neisseria meningitidis capsular polysaccharides induce inflammatory responses via TLR2 and TLR4-MD-2. JLB, 2011. PUBMED
Panas, M.W., Xie, Z., Panas, H.N., Hoener, M.C., Vallender, E.J., and Miller, G.M. Trace Amine Associated Receptor 1 Signaling in Activated Lymphocytes. J. Neuroimmune Pharmacol., 2011. PUBMED
Lichten LA, Ryu MS, Guo L, Embury J, Cousins RJ. MTF-1-mediated repression of the zinc transporter Zip10 is alleviated by zinc restriction. PLoS One, 2011. PUBMED
Seah C, Levy MA, Jiang Y, Mokhtarzada S, Higgs DR, Gibbons RJ, Berube NG. Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53. J. Neurosci., Nov 2008; 28: 12570 - 12580. PUBMED
Sun X, Ritzenthaler JD, Zheng Y, Roman J, Han S. Rosiglitazone inhibits alpha4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals. Mol Cancer Ther. 2009 Jan;8(1):110-8. PUBMED
Healy NC, O'Connor R Sequestration of PDLIM2 in the cytoplasm of monocytic/macrophage cells is associated with adhesion and increased nuclear activity of NF-{kappa}B. J Leukoc Biol. 2008 Dec 3. [Epub ahead of print] PUBMED
McKay BR, O'Reilly CE, Phillips SM, Tarnopolsky MA, Parise G. Co-expression of IGF-1 family members with myogenic regulatory factors following acute damaging muscle-lengthening contractions in humans. J Physiol. 2008 Nov 15;586(Pt 22):5549-60. Epub 2008 Sep 25. PUBMED
Hsu LJ, Schultz L, Hong Q, Van Moer K, Heath J, Li MY, Lai FJ, Lin SR, Lee MH, Lo CP, Lin YS, Chen ST, Chang NS. Transforming growth factor beta1 signaling via interaction with cell surface J Biol Chem. 2009 Jun 5;284(23):16049-59. Epub 2009 Apr 14.PUBMED
Kirchhoff T, Chen ZQ, Gold B, Pal P, Gaudet MM, Kosarin K, Levine DA, Gregersen P, Spencer S, Harlan M, Robson M, Klein RJ, Hudis CA, Norton L, Dean M, Offit K. The 6q22.33 locus and breast cancer susceptibility. Cancer Epidemiol Biomarkers Prev. 2009 Sep;18(9):2468-75. Epub 2009 Aug 18.PUBMED
Kawakami K, Hirata H, Yamamura S, Kikuno N, Saini S, Majid S, Tanaka Y, Kawamoto K, Enokida H, Nakagawa M, Dahiya R. Functional significance of Wnt inhibitory factor-1 gene in kidney cancer. Cancer Res. 2009 Nov 15;69(22):8603-10. Epub 2009 Nov 3.PUBMED
Catalgol B, Ziaja I, Breusing N, Jung T, Höhn A, Alpertunga B, Schroeder P, Chondrogianni N, Gonos ES, Petropoulos I, Friguet B, Klotz LO, Krutmann J, Grune T. The proteasome is an integral part of solar ultraviolet a radiation-induced gene expression. J Biol Chem. 2009 Oct 30;284(44):30076-86. Epub 2009 Aug 18.PUBMED
Pavlov TS, Levchenko V, Karpushev AV, Vandewalle A, Staruschenko A. Peroxisome proliferator-activated receptor gamma antagonists decrease Na+ transport via the epithelial Na+ channel. Mol Pharmacol. 2009 Dec;76(6):1333-40. Epub 2009 Sep 14.PUBMED
Sharma SD, Meeran SM, Katiyar N, Tisdale GB, Yusuf N, Xu H, Elmets CA, Katiyar SK. IL-12 deficiency suppresses 12-O-tetradecanoylphorbol-13-acetate-induced skin tumor development in 7,12-dimethylbenz(a)anthracene-initiated mouse skin through inhibition of inflammation. Carcinogenesis. 2009 Nov;30(11):1970-7. Epub 2009 Sep 16.PUBMED
Sharma S, Lichtenstein A. Aberrant splicing of the E-cadherin transcript is a novel mechanism of gene silencing in chronic lymphocytic leukemia cells. Blood. 2009 Nov 5;114(19):4179-85. Epub 2009 Sep 10.PUBMED
Kalogeropoulos M, Varanasi SS, Olstad OK, Sanderson P, Gautvik VT, Reppe S, Francis RM, Gautvik KM, Birch MA, Datta HK. Zic1 transcription factor in bone: neural developmental protein regulates mechanotransduction in osteocytes. FASEB J. 2010 Apr 6. [Epub ahead of print]PUBMED
Barnholt KE, Kota RS, Aung HH, Rutledge JC. Adenosine blocks IFN-gamma-induced phosphorylation of STAT1 on serine 727 to reduce macrophage activation. J Immunol. 2009 Nov 15;183(10):6767-77. Epub 2009 Oct 21.PUBMED
Liu P, Li H, Cepeda J, Xia Y, Kempf JA, Ye H, Zhang LQ, Ye SQ. Regulation of inflammatory cytokine expression in pulmonary epithelial cells by pre-B-cell colony-enhancing factor via a nonenzymatic and AP-1-dependent mechanism. J Biol Chem. 2009 Oct 2;284(40):27344-51. Epub 2009 Aug 4.PUBMED
Cignal™ Lenti Reporter Assay System
Kim YK, Ha HH, Lee JS, Bi X, Ahn YH, Hajar S, Lee JJ, Chang YT. Control of muscle differentiation by a mitochondria-targeted fluorophore. J Am Chem Soc. 2010 Jan 20;132(2):576-9.PUBMED


Cignal™ Finder Reporter Arrays
Greer, R. M. et al.. SMAC Mimetic (JP1201) Sensitizes Non-Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α-Independent Manner. Cancer Res., 2011. PUBMED
Campeau, P.M., Rafei, M., Boivin, M.-N., Sun, Y., Grabowski, G.A., and Galipeau, J. Characterization of Gaucher disease bone marrow mesenchymal stromal cells reveals an altered inflammatory secretome. Blood, 2009 PUBMED
Elyakim, E. et al.. hsa-miR-191 Is a Candidate Oncogene Target for Hepatocellular Carcinoma Therapy. Cancer Res., 2010. PUBMED
Zughaier, S.M.. Neisseria meningitidis capsular polysaccharides induce inflammatory responses via TLR2 and TLR4-MD-2. JLB, 2011. PUBMED
Panas, M.W., Xie, Z., Panas, H.N., Hoener, M.C., Vallender, E.J., and Miller, G.M. Trace Amine Associated Receptor 1 Signaling in Activated Lymphocytes. J. Neuroimmune Pharmacol., 2011. PUBMED
Lichten LA, Ryu MS, Guo L, Embury J, Cousins RJ. MTF-1-mediated repression of the zinc transporter Zip10 is alleviated by zinc restriction. PLoS One, 2011. PUBMED
Naouar, M. et al. The new protein FAM110B regulates the expression of E-cadherin and is involved in cell migration and invasion. Cancer Res., 2011. PUBMED


RT² First Strand Kit
Bruno RD, Gover TD, Burger AM, Brodie AM, Njar VC. 17alpha-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response. Mol Cancer Ther. 2008 Sep;7(9):2828-36. PUBMED
Kerber M, Reiss Y, Wickersheim A, Jugold M, Kiessling F, Heil M, Tchaikovski V, Waltenberger J, Shibuya M, Plate KH, Machein MR. Flt-1 signaling in macrophages promotes glioma growth in vivo. Cancer Res. 2008 Sep 15;68(18):7342-51. PUBMED
Hideshima T, Ikeda H, Chauhan D, Okawa Y, Raje N, Podar K, Mitsiades C, Munshi NC, Richardson PG, Carrasco RD, Anderson KC. Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma Blood. 2009 Jul 30;114(5):1046-52. Epub 2009 May 12.PUBMED
Hideshima T, Chauhan D, Kiziltepe T, Ikeda H, Okawa Y, Podar K, Raje N, Protopopov A, Munshi NC, Richardson PG, Carrasco RD, Anderson KC. Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: Blood. 2009 May 21;113(21):5228-36. Epub 2009 Mar 6.PUBMED
Xiang J, McLinden JH, Rydze RA, Chang Q, Kaufman TM, Klinzman D, Stapleton JT. Viruses within the Flaviviridae decrease CD4 expression and inhibit HIV replication in human CD4+ cells. J Immunol. 2009 Dec 15;183(12):7860-9PUBMED
Chan SK, Riley PR, Price KL, McElduff F, Winyard PJ, Welham SJ, Woolf AS, Long DA. Corticosteroid-induced kidney dysmorphogenesis is associated with deregulated expression of known cystogenic molecules, as well as Indian hedgehog. Am J Physiol Renal Physiol. 2010 Feb;298(2):F346-56. Epub 2009 Dec 9.PUBMED


XpressRef Human Universal Total RNA
Palermo A, Doyonnas R, Bhutani N, Pomerantz J, Alkan O, Blau HM. Nuclear reprogramming in heterokaryons is rapid, extensive, and bidirectional. FASEB J. 2009 Jan 13. [Epub ahead of print] PUBMED
Devosse T, Guillabert A, D'Haene N, Berton A, De Nadai P, Noel S, Brait M, Franssen JD, Sozzani S, Salmon I, Parmentier M. Formyl peptide receptor-like 2 is expressed and functional in plasmacytoid J Immunol. 2009 Apr 15;182(8):4974-84.PUBMED


RT² qPCR-Grade RNA isolation kit
Dyer KD, Percopo CM, Fischer ER, Gabryszewski SJ, Rosenberg HF. Pneumoviruses infect eosinophils and elicit MyD88-dependent release of Blood. 2009 Sep 24;114(13):2649-56. Epub 2009 Aug 3.PUBMED
Qiu Z, Dyer KD, Xie Z, Radinger M, Rosenberg HF. GATA transcription factors regulate the expression of the human J Biol Chem. 2009 May 8;284(19):13099-109. Epub 2009 Mar 10.PUBMED


SureFECT™ Transfection Reagent
Rashid S, Pilecka I, Torun A, Olchowik M, Bielinska B, Miaczynska M. Endosomal adaptor proteins APPL1 and APPL2 are novel activators of J Biol Chem. 2009 Jul 3;284(27):18115-28. Epub 2009 May 11.PUBMED

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EpiTect Methyl qPCR Arrays & Assays
Jaspers I, Horvath KM, Zhang W, Brighton LE, Carson JL, Noah TL.Reduced Expression of IRF7 in Nasal Epithelial Cells from Smokers after Infection with Influenza. Am J Respir Cell Mol Biol. 2010 Sep;43(3):368-75. Epub 2009 Oct 30.PUBMED
Chamberlain SJ, Chen PF, Ng KY, Bourgois-Rocha F, Lemtiri-Chlieh F, Levine ES, Lalande M. Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader-Willi syndromes. Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17668-73. Epub 2010 Sep 27. PUBMED
Jung H. Kim, Saravana M. Dhanasekaran, John R. Prensner, Xuhong Cao, Daniel Robinson, Shanker Kalyana-Sundaram, Christina Huang, Sunita Shankar, Xiaojun Jing, Matthew Iyer, Ming Hu, Lee Sam, Catherine Grasso, Christopher A. Maher, Nallasivam Palanisamy, Rohit Mehra, Hal D. Kominsky, Javed Siddiqui, Jindan Yu, Zhaohui S. Qin, and Arul M. Chinnaiyan Deep sequencing reveals distinct patterns of DNA methylation in prostate cancer Genome Res., Jul 2011; 21: 1028 - 1041. PUBMED
Kibriya MG, Raza M, Jasmine F, Roy S, Paul-Brutus R, Rahaman R, Dodsworth C, Rakibuz-Zaman M, Kamal M, Ahsan H. A genome-wide DNA methylation study in colorectal carcinoma BMC Medical Genomics, Jun 2011; 4(10:50 PUBMED
Ceccarelli V, Racanicchi S, Martelli MP, Nocentini G, Fettucciari K, Riccardi C, Marconi P, Di Nardo P, Grignani F, Binaglia L, Vecchini A. Eicosapentaenoic Acid Demethylates a Single CpG That Mediates Expression of Tumor Suppressor CCAAT/Enhancer-binding Protein {delta} in U937 Leukemia Cells. J Biol Chem. 2011 Aug 5;286(31):27092-102 PUBMED

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